9 research outputs found
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N-Acetylaspartate as an in vivo Marker of Neuronal Viability in Kainate-Induced Status Epilepticus: 1H Magnetic Resonance Spectroscopic Imaging
N-acetylaspartate (NAA) has been proposed as a marker of neuronal density. Therefore, regional measurement of NAA by magnetic resonance spectroscopic imaging (MRSI) may provide a sensitive method for detection of selective neuronal loss, in contrast to conventional imaging techniques such as magnetic resonance imaging (MRI). To test this hypothesis, we produced selective neuronal injury by kainate-induced status epilepticus. Three days later three-dimensional 1H-MRSI was obtained and compared with conventional T2-weighted MRI and histological findings in normal and kainatetreated rats. Reduction of NAA determined by MRSI in piriform cortex, amygdala, and hippocampus correlated well with neuronal injury determined from histology. Changes of NAA, without any MRI changes in hippocampus, indicated greater sensitivity of MRSI for detection of neuronal injury. These results are consistent with the hypothesis that reduction of NAA measured by MRSI may be a sensitive marker of neuronal injury in vivo in a variety of disease states
Detection of necrotic neural response in super-acute cerebral ischemia using activity-induced manganese-enhanced (AIM) MRI
Synthesis of adherent insoluble glucan by the concerted action of the two glucosyltransferase components of Streptococcus mutans
Detection of necrotic neural response in super-acute cerebral ischemia using activity-induced manganese-enhanced (AIM) MRI
Diffusion-weighted Line-scan Echo-planar Spectroscopic Imaging Technique to Reduce Motion Artifacts in Metabolite Diffusion Imaging
Effects of galvanic vestibular stimulation combined with physical therapy on unilateral spatial neglect and pusher behavior in stroke patient
単独の半側空間無視(USN)とPusher現象(Pusher)を呈する症例に対してそれぞれ効果的介入として,直流前庭電気刺激(GVS)が報告されている.しかし,これらの症候の合併例に治療効果を示したものは未だにない.今回,USNとPusherを合併した患者にGVSを行い効果検証した.症例は70歳代女性で,診断名は右内包後脚の脳梗塞であった.実験デザインは,シングルケースABA´デザインを使用した.発症後34日目にA期を開始し通常介入を行い,B期では通常介入に加えGVSを各期間2週間ずつ実施した.GVSは,理学療法前に座位で20分,1.5 mAで行った.効果判定として,USNの評価はBIT通常検査,Bells test,CBS,Pusherの評価はSCP,BLSを各期の前後で実施した.結果は,A期A´期でいずれも改善を認めなかったが,B期ではBells test,CBS,SCP,BLSにおいて改善を示した.以上よりUSNとPusherを合併した症例において,GVSはいずれの症状の改善にも効果を示した.東京都立大学学位論文甲第1251号 副論文journal articl
半側空間無視とPusher現象の合併症例に対する直流前庭電気刺激の効果
単独の半側空間無視(USN)とPusher現象(Pusher)を呈する症例に対してそれぞれ効果的介入として,直流前庭電気刺激(GVS)が報告されている.しかし,これらの症候の合併例に治療効果を示したものは未だにない.今回,USNとPusherを合併した患者にGVSを行い効果検証した.症例は70歳代女性で,診断名は右内包後脚の脳梗塞であった.実験デザインは,シングルケースABA´デザインを使用した.発症後34日目にA期を開始し通常介入を行い,B期では通常介入に加えGVSを各期間2週間ずつ実施した.GVSは,理学療法前に座位で20分,1.5 mAで行った.効果判定として,USNの評価はBIT通常検査,Bells test,CBS,Pusherの評価はSCP,BLSを各期の前後で実施した.結果は,A期A´期でいずれも改善を認めなかったが,B期ではBells test,CBS,SCP,BLSにおいて改善を示した.以上よりUSNとPusherを合併した症例において,GVSはいずれの症状の改善にも効果を示した.東京都立大学学位論文甲第1251号 副論
Acid Activation of Trpv1 Leads to an Up-Regulation of Calcitonin Gene-related Peptide Expression in Dorsal Root Ganglion Neurons via the CaMK-CREB Cascade: A Potential Mechanism of Inflammatory Pain
Increased CGRP expression in sensory neurons is associated with inflammatory pain. We examined the molecular basis of CGRP expression and found that acid-sensing nociceptor Trpv1 is activated under inflammatory acidic environments and up-regulates the CGRP expression through CaMK-CREB cascade