57 research outputs found
Sustainable Drugs against NTDs: Lessons learned from investigating the potential use of propolis-based natural products for treating various forms of human and animal trypanosomiasis
The Activity of Red Nigerian Propolis and Some of Its Components against Trypanosoma brucei and Trypanosoma congolense
Sustainable Drugs against NTDs: Lessons learned from investigating the potential use of propolis-based natural products for treating various forms of human and animal trypanosomiasis
Identification of new lead compounds for the treatment of African trypanosomiasis
No abstract available
In vivo neutralization of Naja nigricollis venom by Uvaria chamae
<i>Uvaria chamae</i> is a well known medicinal plant in Nigerian traditional medicine for the management of many diseases, but investigations concerning its pharmacological characteristics are rare. In this study, we evaluate its venom neutralizing properties against <i>Naja nigricollis</i> venom in rats. Freshly collected <i>Uvaria chamae</i> leaves were air dried, powdered and extracted in methanol. To study the antivenom properties, albino rats were orally administered with a dose of 400 mg kg<sup>-1</sup> body weight and one hour later, the venom was administered intraperitoneally at a dose of 0.08 mg kg<sup>-1</sup> body weight of rats. Albino rats (male) weighing between 180-200g were randomly divided into five (5) groups of three (3). Groups 1-5 received water, normal saline, venom, <i>Uvaria chamae</i> and venom, <i>Uvaria chamae</i> respectively. Blood clothing time, bleeding time, antipyretic activity, haemoglobin, RBC, WBC, creatine kinase, AST, ALP and ALT activities total protein antioxidant activity and some blood electrolytes, plasma urea and uric acid were measured. Our results showed that <i>Uvaria chamae</i> methanol extract neutralized some biological effects of <i>Naja nigricollis</i> venom. The venom increased the rectal temperature, enzyme activities, bleeding time and other blood parameters. The plant extract was able to reduce these parameters in the extract treated groups. Details of the results are discussed. From this study, it is clear that <i>U. chamae</i> leaf extract had antivenom activity in animal models. The above results indicate that the plant extract possess potent snake venom neutralizing capacity and could potentially be used for therapeutic purpose in case of snake bite envenomation
Suppressive, curative, and prophylactic potentials of Morinda lucida (benth) against mice-infective chloroquine-sensitive Plasmodium berghei NK-65.
Assessment of Biological Activities:A Comparison of Pergularia daemia and Jatropha curcas Leaf Extracts
Antihypertensive Effect of Methanol Extract of Napoleona imperialis (p. beauv) in adrenaline induced hypertensive albino rats
Suppressive, curative, and prophylactic potentials of Morinda lucida (benth) against mice-infective chloroquine-sensitive Plasmodium berghei NK-65.
- …