5 research outputs found
Evaluation of medical and/or surgical treatment of anosmia/hyposmia in association with inflammatory disease of the upper airway
Background: There is a lack of evidence-based, prospective studies in
treatment of nasal polyposis. The correlations between symptoms, polyp
scores and computed tomography (CT) scans have not been studied
sufficiently. Little, if any, sense of smell is common in nasal
inflammatory disease. It is clinically well-known that the quality of
life deteriorates when one starts to lose the sense of smell.
Aims: I & III. To compare the effects of medical treatment and combined
surgical / medical treatment on olfaction, polyp scores and symptoms in
patients with nasal polyposis and evaluate CT scans as a method for
comparing these effects. II. To compare the effects on olfaction of
topical glucocorticoid treatment and placebo given for six months in
addition to oral glucocorticoids for 10 days, in patients with anosmia /
hyposmia. IV. To study the effects of loss of smell on the patient s
quality of life and the coping strategies used.
Methods: I & III. Thirty-two patients with nasal polyposis were
randomized to unilateral endoscopic sinus surgery after pretreatment with
oral prednisolone for 10 days and nasal budesonide bilaterally for one
month. Postoperatively, they were given nasal steroids (budesonide)
bilaterally for one year. During this period, they were assessed with
nasal endoscopy, symptom scores and olfactory thresholds. CT-scans of the
sinuses, performed before and one year after operation, were evaluated
using the Lund staging system. II. The study was randomized, double-blind
and placebo-controlled. The criterion for inclusion in the blinded phase
was an improvement of at least two steps in the butanol odour threshold
test, after open treatment for 10 days with oral and nasal
corticosteroids. Forty patients were included. Twenty of them were
randomized to treatment with fluticasone propionate, 10 to placebo and 10
others served as controls. The topical treatment was continued for 6
months. IV. Seventy-two patients with anosmia (46%) or hyposmia (54%)
filled in the validated Multi-clinic Smell and Taste Questionnaire, the
validated General Well-being Schedule (GWBS) and answered other questions
shown to be of good validity.
Results: I. The combination of local and oral steroids, improved the
sense of smell, but surgery had no additional effect. Symptom scores
became significantly better with medical treatment alone and surgery had
additional beneficial effects on nasal obstruction and secretions as well
as polyp scores. III. From before to one year after surgery, we found a
significant improvement in the CT total scores, osteomeatal complex (OMC)
and the maxillary sinus scores, on the operated side, but not on the
unoperated side. II. The three groups showed a similar improvement in
their sense of smell after the initial 10-day treatment with combined
oral and nasal corticosteroids. Patients who continued the local
treatment maintained their improvement at the same level during the study
whether or not they had been given nasal corticosteroids or placebo. We
found no significant differences between the treatment groups. IV.
Several negative effects were common, i.e., risks associated with the
loss of smell, interference with daily routines and deterioration in well
being. Physical health, financial security, profession, partnership,
friendships, emotional stability and leisure also seemed to be negatively
affected and GWBS scores showed a reduction in psychological well being.
The patients became more aware of the importance of olfaction after its
loss, and adopted several types of problem- and emotion-focused coping
strategies.
Conclusions: I. Medical treatment seems to be sufficient for the
treatment of most symptoms of nasal polyposis. When hyposmia is the main
symptom no additional benefit seems to be gained from surgical treatment.
If nasal obstruction is the chief problem after steroid treatment,
surgical treatment is indicated. Selection of those who will benefit from
surgery should be based on the patient s symptoms and not on the
physician s polyp score. III. CT of the sinuses shows long-lasting
improvement in the total and CT scores of the OMC after combined surgical
and corticosteroid treatment, as compared to medical treatment alone. II.
In patients with anosmia/hyposmia partly caused by local inflammation, no
further improvement in the olfactory threshold is achieved by continuing
to use a topical intranasal glucocorticoid after an initial combined
topical and systemic glucocorticoid treatment. IV. We found that the loss
of smell had substantial adverse effects on the quality of life and that
high priority should be given to its diagnosis and treatment. Moreover, a
combination of problem- and emotion-focused coping strategies may be
suggested to patients who have recently lost their sense of smell
Effects of FESS and additional fluticasone propionate nasal drops on psychological well-being in nasal polyposis with asthma
Conclusion: A combined therapy of fluticasone propionate nasal drops (FPND) and functional endoscopic sinus surgery (FESS) can improve quality of life (QoL). When compared with prior data, the results imply that a generic measure of psychological aspects of QoL may be better than measures of respiratory symptoms and clinical parameters to capture a patient's perception of the disease and its treatment. Objective: To better understand effects of FPND and FESS on generic QoL. Methods: Sixty nasal polyposis patients with concomitant asthma completed participation in a randomized, double-blind, placebo-controlled, 14-week study in which they responded to the General Well-Being Schedule (GWBS). Results: GWBS scores (i) increased significantly after administration of FPND, independent of FESS (from lower than normal to normal), (ii) increased after FESS independent of FPND (from lower than normal to normal), and (iii) increased additively after FPND and FESS
Effects of FESS and additional fluticasone propionate nasal drops on psychological well-being in nasal polyposis with asthma
Abstract Conclusion: A combined therapy of fluticasone propionate nasal drops (FPND) and functional endoscopic sinus surgery (FESS) can improve quality of life (QoL). When compared with prior data, the results imply that a generic measure of psychological aspects of QoL may be better than measures of respiratory symptoms and clinical parameters to capture a patient's perception of the disease and its treatment. Objective: To better understand effects of FPND and FESS on generic QoL. Methods: Sixty nasal polyposis patients with concomitant asthma completed participation in a randomized, double-blind, placebo-controlled, 14-week study in which they responded to the General Well-Being Schedule (GWBS). Results: GWBS scores (i) increased significantly after administration of FPND, independent of FESS (from lower than normal to normal), (ii) increased after FESS independent of FPND (from lower than normal to normal), and (iii) increased additively after FPND and FESS
Effects of smell loss on daily life and adopted coping strategies in patients with nasal polyposis with asthma
CONCLUSIONS: Results from prior studies of quality of life (QoL) in heterogeneous patient groups (regarding disorder type and etiology) with olfactory disorders may be useful also for understanding QoL in homogeneous patient groups. Diagnosis and treatment of smell loss should be given high priority in polyposis with asthma, and coping strategies can be suggested to these patients. OBJECTIVES: To investigate the effects of smell loss on daily life and coping strategies in patients with smell loss without dysosmia and with nasal polyposis with asthma as the only primary etiology, and to compare these results with those from a prior study of a patient group with heterogeneous olfactory disorders and etiology. METHODS: Fifty patients with smell loss and with nasal polyposis and asthma responded to questions about consequences of smell loss, QoL, psychological well-being and distress, and coping strategies. RESULTS: Negative consequences of smell loss, associated risks, and diminished food enjoyment were commonly reported, and various aspects of QoL were rated as being deteriorated. Psychological well-being was found to be poorer than normal, and use of both problem- and emotion-focused strategies was common. The results from this homogeneous patient group are very similar to those previously obtained from a heterogeneous group