1,377 research outputs found
A Model for the Voltage Steps in the Breakdown of the Integer Quantum Hall Effect
In samples used to maintain the US resistance standard the breakdown of the
dissipationless integer quantum Hall effect occurs as a series of dissipative
voltage steps. A mechanism for this type of breakdown is proposed, based on the
generation of magneto-excitons when the quantum Hall fluid flows past an
ionised impurity above a critical velocity. The calculated generation rate
gives a voltage step height in good agreement with measurements on both
electron and hole gases. We also compare this model to a hydrodynamic
description of breakdown.Comment: 4 pages including 3 figure
Cytogenetic studies of early myeloid progenitor compartments in Ph<SUP>1</SUP>- positive chronic myeloid leukemia. II. Long-term culture reveals the persistence of Ph<SUP>1</SUP>-negative progenitors in treated as well as newly diagnosed patients
We recently showed that long-term marrow cultures can be used to demonstrate the presence of Philadelphia (Ph1) negative progenitors in patients with newly diagnosed Ph1-positive chronic myeloid leukemia (CML). We now report results for 6 chronic phase patients studied 5-83 mo postdiagnosis and an additional 3 newly diagnosed patients. Marrow metaphases were exclusively Ph1-positive. Clonogenic assays revealed a minor population of Ph1-negative progenitors in 3 cases (1 treated, 2 untreated). Long-term marrow culture adherent layers contained Ph1- negative progenitors in 6 cases (3 treated, 3 untreated). Whenever this occurred, the Ph1-negative population had become the only one detectable within 3-4 wk, and this was always associated with a rapid decline of the Ph1-positive population. For 2 of the 3 cases where Ph1- negative progenitors were not detected, there was a similar rapid decline in the Ph1-positive population in culture. In the other case, Ph1-positive progenitors were maintained at levels typically seen in normal long-term marrow cultures. These results suggest that chromosomally normal stem cells may persist for a considerable period in the marrow of some, but perhaps not all, patients with CML, even in the face of maintenance chemotherapy. In addition, they provide new evidence of heterogeneity in this disease, as shown by the variable ability of Ph1-positive progenitor populations to be maintained in vitro
Changes in the Proliferative Activity of Human Hematopoietic Stem Cells in NOD/SCID Mice and Enhancement of Their Transplantability after In Vivo Treatment with Cell Cycle Inhibitors
Human hematopoietic tissue contains rare stem cells with multilineage reconstituting ability demonstrable in receptive xenogeneic hosts. We now show that within 3 wk nonobese diabetic severe combined immunodeficiency (NOD/SCID) mice transplanted with human fetal liver cells regenerate near maximum levels of daughter human hematopoietic stem cells (HSCs) able to repopulate secondary NOD/SCID mice. At this time, most of the human HSCs (and other primitive progenitors) are actively proliferating as shown by their sensitivity to treatments that kill cycling cells selectively (e.g., exposure to high specific-activity [3H]thymidine in vitro or 5-fluorouracil in vivo). Interestingly, the proliferating human HSCs were rapidly forced into quiescence by in vivo administration of stromal-derived factor-1 (SDF-1) and this was accompanied by a marked increase in the numbers of human HSCs detectable. A similar result was obtained when transforming growth factor-β was injected, consistent with a reversible change in HSCs engrafting potential linked to changes in their cell cycle status. By 12 wk after transplant, most of the human HSCs had already entered Go and treatment with SDF-1 had no effect on their engrafting activity. These findings point to the existence of novel mechanisms by which inhibitors of HSC cycling can regulate the engrafting ability of human HSCs executing self-renewal divisions in vivo
Surface Instabilities on Liquid Oxygen in an Inhomogeneous Magnetic Field
Liquid oxygen exhibits surface instabilities when subjected to a sufficiently
strong magnetic field. A vertically oriented magnetic field gradient both
increases the magnetic field value at which the pattern forms and shrinks the
length scale of the surface patterning. We show that these effects of the field
gradient may be described in terms of an ``effective gravity'', which in our
experiments may be varied from 1g to 360g.Comment: 4 pages, 5 embedded figures in eps forma
Electronic Processes at the Breakdown of the Quantum Hall Effect
Microscopic processes giving the energy gain and loss of a two-dimensional
electron system in long-range potential fluctuations are studied theoretically
at the breakdown of the quantum Hall effect in the case of even-integer filling
factors. The Coulomb scattering within a broadened Landau level is proposed to
give the gain, while the phonon scattering to give the loss. The energy balance
equation shows that the electron temperature T_e and the diagonal conductivity
sigma_{xx} exhibit a bistability above the lower critical electric field
E_{c1}. Calculated values of E_{c1} as well as T_e and sigma_{xx} at E_{c1} are
in agreement with the observed values in their orders of magnitude.Comment: 4 pages, 2 Postscript figures, submitted to the Journal of the
Physical Society of Japa
Magneto-Optical Study of Correlated Electron–Hole Layers in Single-Barrier Heterostructures
Probing the Sensitivity of Electron Wave Interference to Disorder-Induced Scattering in Solid-State Devices
The study of electron motion in semiconductor billiards has elucidated our
understanding of quantum interference and quantum chaos. The central assumption
is that ionized donors generate only minor perturbations to the electron
trajectories, which are determined by scattering from billiard walls. We use
magnetoconductance fluctuations as a probe of the quantum interference and show
that these fluctuations change radically when the scattering landscape is
modified by thermally-induced charge displacement between donor sites. Our
results challenge the accepted understanding of quantum interference effects in
nanostructures.Comment: 8 pages, 5 figures, Submitted to Physical Review
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