Symmetry-breaking Effects for Polariton Condensates in Double-Well Potentials

We study the existence, stability, and dynamics of symmetric and anti-symmetric states of quasi-one-dimensional polariton condensates in double-well potentials, in the presence of nonresonant pumping and nonlinear damping. Some prototypical features of the system, such as the bifurcation of asymmetric solutions, are similar to the Hamiltonian analog of the double-well system considered in the realm of atomic condensates. Nevertheless, there are also some nontrivial differences including, e.g., the unstable nature of both the parent and the daughter branch emerging in the relevant pitchfork bifurcation for slightly larger values of atom numbers. Another interesting feature that does not appear in the atomic condensate case is that the bifurcation for attractive interactions is slightly sub-critical instead of supercritical. These conclusions of the bifurcation analysis are corroborated by direct numerical simulations examining the dynamics of the system in the unstable regime.MICINN (Spain) project FIS2008- 0484

Immunolocalization and Adenoviral Vector-mediated Manganese Superoxide Dismutase Gene Transfer to Experimental Oral Tumors

The anti-oxidant enzyme system protects cellular macromolecules against damage from reactive oxygen species. One component of this system, manganese superoxide dismutase (MnSOD), has also been shown to display tumor suppressor gene-like activity. The purpose of this study was to examine changes in MnSOD expression during hamster cheek pouch carcinogenesis, and the effects of MnSOD overexpression using an adenoviral vector. Tumor induction was carried out using 7,12-dimethylbenz[α]anthracene. Animals were killed at periodic intervals, and check pouch tissues were excised and examined for MnSOD expression by immunohistochemistry and digital image analysis. We observed a reduction in MnSOD expression as early as 2 weeks after the start of carcinogen application. Low MnSOD expression persisted until the end of the 23-week experimental period. Solid hamster cheek pouch carcinoma xenografts were then established in nude mice. An adenoviral vector encoding the human MnSOD gene was delivered to the xenografts by direct injection. We observed high, immediate expression of MnSOD in the xenografts that persisted for 10 days following cessation of viral construct delivery. Delivery of the MnSOD construct resulted in a maximal 50% reduction in tumor growth compared with untreated controls. Our results suggest that MnSOD may be a tumor suppressor gene in the hamster cheek pouch model system. </jats:p