The Impact of External Pressure on Companies' Responses to Sanctions: an International Comparative Study

What explains the strategies firms adopt in response to economic sanctions? Our study argues that different types of external pressure, such as public shaming, the nature of companies' business relationships, and national-level legal-regulatory environments affects how firms respond to the sanctions imposed against Russia after its 2022 invasion of Ukraine. We develop a suite of hypotheses about how external pressure affects firms' compliance behaviors and whether firms adopt reactive and/or proactive strategic responses. We test our hypotheses by analyzing results from a survey of 610 medium-sized companies operating in Germany, Poland, and the United States. Using structural equation modeling (SEM), we find that external pressure is associated with higher levels of compliance and overcompliance with sanctions but is also associated with undercompliant behavior. We also find that compliance with sanctions is associated with a high degree of proactive response, which suggests compliant firms may often seek out legal means of circumventing sanctions. We further observed variation in the effects of external pressure, compliance behavior, and strategic responses on US firms compared to those in European Union members Germany and Poland

RPR Review of Policy Research Preferences, Knowledge, and Citizen Probability Assessments of the Terrorism Risk of Nuclear Powerr opr_552 207..227

Abstract How does the American public assess risk when it comes to national security issues? This paper addresses this question by analyzing variation in citizen probabilit

Preferences, Knowledge, and Citizen Probability Assessments of the Terrorism Risk of Nuclear Power

The definitive version is available at www.interscience.wiley.com.How does the American public assess risk when it comes to national security issues? This paper addresses this question by analyzing variation in citizen probability assessments of the terrorism risk of nuclear power plants. Drawing on the literature on how motivated reasoning, selective information processing, and domain specific knowledge influence public opinion, we argue that heterogeneous issue preferences and knowledge of nuclear energy and homeland security have important explanatory power. Using original data from a unique 2009 national survey in the United States, we show that Americans are divided in their probability assessments of the terrorism risk of nuclear power plants. Consistent with our theoretical expectations, individuals who support using nuclear power to meet rising energy demands, who are generally less concerned with terrorism, or who are more knowledgeable about terrorism and nuclear security tend to provide lower assessments of the likelihood that nuclear power plants increase terrorist attacks, and vice versa. The findings have implications for the literature on public opinion, risk assessment, energy policy and planning, and homeland security.This material is based upon work supported by the U.S. Department of Homeland Security under Grant Award Number 2008-DN-077-ARI018-03. The views and conclusions in the paper are those of the authors and should not be interpreted as necessarily representing the official policies, either expressed or implied, of the U.S. Department of Homeland Security

ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry

ProSight PTM 2.0 (http://prosightptm2.scs.uiuc.edu) is the next generation of the ProSight PTM web-based system for the identification and characterization of proteins using top down tandem mass spectrometry. It introduces an entirely new data-driven interface, integrated Sequence Gazer for protein characterization, support for fixed modifications, terminal modifications and improved support for multiple precursor ions (multiplexing). Furthermore, it supports data import and export for local analysis and collaboration

Highly multiplexed, label-free proteoform imaging of tissues by individual ion mass spectrometry.

Imaging of proteoforms in human tissues is hindered by low molecular specificity and limited proteome coverage. Here, we introduce proteoform imaging mass spectrometry (PiMS), which increases the size limit for proteoform detection and identification by fourfold compared to reported methods and reveals tissue localization of proteoforms at <80-μm spatial resolution. PiMS advances proteoform imaging by combining ambient nanospray desorption electrospray ionization with ion detection using individual ion mass spectrometry. We demonstrate highly multiplexed proteoform imaging of human kidney, annotating 169 of 400 proteoforms of <70 kDa using top-down MS and a database lookup of ~1000 kidney candidate proteoforms, including dozens of key enzymes in primary metabolism. PiMS images reveal distinct spatial localizations of proteoforms to both anatomical structures and cellular neighborhoods in the vasculature, medulla, and cortex regions of the human kidney. The benefits of PiMS are poised to increase proteome coverage for label-free protein imaging of tissues

Prospectus, February 4, 1981

12 RUNNING FOR POSITIONS IN STU GO.; Severns speaks to Community News Class; Sign up for student insurance; $1.50 a gallon? Ouch!: Instructiors discuss oil de-regulation; Everything you always wanted to know about participating in class!; Did you know that?; The Ice Capades \u27celebrates\u27 at the Hall Feb. 10-15; Muddy Waters: Is he the father of Rock n\u27 Roll?; Media 1000$ catches Parkland\u27s eyes!; Ramblin\u27...; Classifieds; Homer has big celebration for their hero: Paul Lewis; 11 Amendments to Stugo Constitution; 250 enrolled in Learning Lab.; It\u27s Susan B. Anthony\u27s b-day!; 42 donated at the Blood Drive; Images getting ready to hit the presses.; Women\u27s team boosts record to 19-1; Cobras beat arch-rival Lake Land; Dunson slam takes game into overtime: Cobras upset No. 1 Kankakee in double OT; Women beat Cavaliers; Softball practice begins Feb. 9; Geoff Ray wins FF competition; Fast Freddy Contest; Collins, the perfect leaderhttps://spark.parkland.edu/prospectus_1981/1028/thumbnail.jp

Phocine distemper Virus: Current knowledge and future directions

Phocine distemper virus (PDV) was first recognized in 1988 following a massive epidemic in harbor and grey seals in north-western Europe. Since then, the epidemiology of infection in North Atlantic and Arctic pinnipeds has been investigated. In the western North Atlantic endemic infection in harp and grey seals predates the European epidemic, with relatively small, localized mortality events occurring primarily in harbor seals. By contrast, PDV seems not to have become established in European harbor seals following the 1988 epidemic and a second event of similar magnitude and extent occurred in 2002. PDV is a distinct species within the Morbillivirus genus with minor sequence variation between outbreaks over time. There is now mounting evidence of PDV-like viruses in the North Pacific/Western Arctic with serological and molecular evidence of infection in pinnipeds and sea otters. However, despite the absence of associated mortality in the region, there is concern that the virus may infect the large Pacific harbor seal and northern elephant seal populations or the endangered Hawaiian monk seals. Here, we review the current state of knowledge on PDV with particular focus on developments in diagnostics, pathogenesis, immune response, vaccine development, phylogenetics and modeling over the past 20 years

A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients

INTRODUCTION: The Oncotype DX assay was recently reported to predict risk for distant recurrence among a clinical trial population of tamoxifen-treated patients with lymph node-negative, estrogen receptor (ER)-positive breast cancer. To confirm and extend these findings, we evaluated the performance of this 21-gene assay among node-negative patients from a community hospital setting. METHODS: A case-control study was conducted among 4,964 Kaiser Permanente patients diagnosed with node-negative invasive breast cancer from 1985 to 1994 and not treated with adjuvant chemotherapy. Cases (n = 220) were patients who died from breast cancer. Controls (n = 570) were breast cancer patients who were individually matched to cases with respect to age, race, adjuvant tamoxifen, medical facility and diagnosis year, and were alive at the date of death of their matched case. Using an RT-PCR assay, archived tumor tissues were analyzed for expression levels of 16 cancer-related and five reference genes, and a summary risk score (the Recurrence Score) was calculated for each patient. Conditional logistic regression methods were used to estimate the association between risk of breast cancer death and Recurrence Score. RESULTS: After adjusting for tumor size and grade, the Recurrence Score was associated with risk of breast cancer death in ER-positive, tamoxifen-treated and -untreated patients (P = 0.003 and P = 0.03, respectively). At 10 years, the risks for breast cancer death in ER-positive, tamoxifen-treated patients were 2.8% (95% confidence interval [CI] 1.7–3.9%), 10.7% (95% CI 6.3–14.9%), and 15.5% (95% CI 7.6–22.8%) for those in the low, intermediate and high risk Recurrence Score groups, respectively. They were 6.2% (95% CI 4.5–7.9%), 17.8% (95% CI 11.8–23.3%), and 19.9% (95% CI 14.2–25.2%) for ER-positive patients not treated with tamoxifen. In both the tamoxifen-treated and -untreated groups, approximately 50% of patients had low risk Recurrence Score values. CONCLUSION: In this large, population-based study of lymph node-negative patients not treated with chemotherapy, the Recurrence Score was strongly associated with risk of breast cancer death among ER-positive, tamoxifen-treated and -untreated patients