The Political Economy of Pro-Poor Livestock Policy in Cambodia

This paper presents a case study of how livestock policies are made and implemented in a national context, and how they can be improved to better serve the interests of the poor in Cambodia. Opportunities exist for improving rural livelihoods in Cambodia through the export of livestock. While Cambodia claims little of the official export market for cattle, huge demand exists within the region and beyond. Three strategic entry points are recommended that can both improve the performance of the sector and the participation of the poor in productive activities.Livestock Production/Industries, Political Economy,

Cambodia’s patient zero: The political economy of foreign aid and avian influenza

What happens when a developing country with poor health infrastructure and even poorer animal health surveillance is thought to be a potential source for the next emerging infectious disease? This is the story of Cambodia and Avian Influenza. This paper undertakes a review of the relevant literature and analyzes the results of detailed semi-structured interviews of individuals highly engaged in Avian Influenza work in Cambodia. First, the political economy context is detailed with particular attention to aid dependency, tourism and the role of the livestock sector. The role of politics and the bureaucracy in this context is explored. Three competing policy narratives emerge: first, kill the birds, but don’t compensate as it’s too difficult and costly; second, behaviour modification change is the answer; and third, whatever happened to poverty and livelihoods? Finally, the political economy of the policy process in Cambodia is described, including actors, networks and interests. The paper finds that in the context of avian influenza, donors are too often motivated by concerns other than protecting livelihoods, just as traditional aid activities are often dominated by the need to tie aid to donor countries, avian influenza activities have been overtly focused on detecting and preventing pandemic as a threat to the donor countries themselves. As of 2008, donors have committed $35 million to Cambodia, placing it seventh among the top 10 recipients of avian influenza funding globally, fourth in terms of per case and per death from A/H5N1, and second in terms of per capita and per outbreak funding. However, ultimate responsibility for the success or failure of policies in Cambodia must rest with those in charge. Poor governance and pervasive institutional failure have plagued the response in Cambodia. Effective disease response and effective governance must go hand-in-hand. A rushed, emergency oriented response to avian influenza may have undermined already weak governance capacity in Cambodia, fuelling patronage networks and encouraging rent seeking. Whether such funds have increased the ability of Cambodia—and the world—to prevent a future pandemic remains uncertain.Highly Pathogenic Avian Influenza, Cambodia, Political Economy

Fighting Corruption with ICT: Strengthening Civil Society’s Role

With information and communication technology, civil society plays an increasing role in governance, promoting transparency and accountability to tackle corruption. Development agencies can strengthen civil society-led, ICT -driven anticorruption initiatives by funding projects and programs that foster institutional environments conducive to participation in public affairs, promote cooperation and mobilization, and develop capacities

Transitional justice dilemma: the case of Cambodia

The last two decades have witnessed a remarkable proliferation of efforts to seek justice that responds adequately to mass atrocity. There is a mounting debate over the desirability and effectiveness of each effort in consolidating justice and peace. This essay offers a perspective for approaching the challenges of transitional justice and assessing policy priorities to improve the responses of transitional justice mechanisms for people whose human rights have been violated. As scholars from Cambodia who lived under the Khmer Rouge regime, we use Cambodia as a case study for analysis. This essay suggests that both trials and truth commission, simultaneously or subsequently, are fundamental during transitional periods in order to achieve better results on behalf of victims, and proposes establishing a community-based forum for Cambodian victims and perpetrators to have a formal dialogue, in addition to the current Khmer Rouge Tribunal

A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin.

Cellular proliferation is antagonistically regulated by canonical and noncanonical Wnt signals; their dysbalance triggers cancers. We previously showed that a multimodular signal transducer, Daple, enhances PI3-K→Akt signals within the noncanonical Wnt signaling pathway and antagonistically inhibits canonical Wnt responses. Here we demonstrate that the PI3-K→Akt pathway serves as a positive feedback loop that further enhances noncanonical Wnt signals by compartmentalizing β-catenin. By phosphorylating the phosphoinositide- (PI) binding domain of Daple, Akt abolishes Daple's ability to bind PI3-P-enriched endosomes that engage dynein motor complex for long-distance trafficking of β-catenin/E-cadherin complexes to pericentriolar recycling endosomes (PCREs). Phosphorylation compartmentalizes Daple/β-catenin/E-cadherin complexes to cell-cell contact sites, enhances noncanonical Wnt signals, and thereby suppresses colony growth. Dephosphorylation compartmentalizes β-catenin on PCREs, a specialized compartment for prolonged unopposed canonical Wnt signaling, and enhances colony growth. Cancer-associated Daple mutants that are insensitive to Akt mimic a constitutively dephosphorylated state. This work not only identifies Daple as a platform for cross-talk between Akt and the noncanonical Wnt pathway but also reveals the impact of such cross-talk on tumor cell phenotypes that are critical for cancer initiation and progression

Justice, forgiveness and the Khmer Rouge Tribunal

Slide presentation discussing justice and forgiveness in Buddhist and Western thought and opinions on the possible outcomes of the Khmer Rouge Tribunal

Book Review by Sophal Ear of The Persistence of Cambodian Poverty: From the Killing Fields to Today written by Harold R. Kerbo

The article of record as published may be located at http://dx.doi.org/10.1355/cs33-3iBook review of: The Persistence of Cambodian Poverty: From the Killing Fields to Today. By Harold R. Kerbo. Jefferson, North Carolina, and London: McFarland & Company, Inc., Publishers, 2011. Softcover: 211pp

Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions.

Polarized distribution of organelles and molecules inside a cell is vital for a range of cellular processes and its loss is frequently encountered in disease. Polarization during planar cell migration is a special condition in which cellular orientation is triggered by cell-cell contact. We demonstrate that the protein Daple (CCDC88C) is a component of cell junctions in epithelial cells which serves like a cellular "compass" for establishing and maintaining contact-triggered planar polarity. Furthermore, these processes may be mediated through interaction with the polarity regulator PARD3. This interaction, mediated by Daple's PDZ-binding motif (PBM) and the third PDZ domain of PARD3, is fine-tuned by tyrosine phosphorylation on Daple's PBM by receptor and non-receptor tyrosine kinases, such as Src. Hypophosphorylation strengthens the interaction, whereas hyperphosphorylation disrupts it, thereby revealing an unexpected role of Daple as a platform for signal integration and gradient sensing for tyrosine-based signals within the planar cell polarity pathway

Systemic effects of tissue plasminogen activator-associated fibrinolysis and its relation to thrombin generation in orthotopic liver transplantation

Orthotopic liver transplantation is frequently associated with hyperfibrinolysis, the origin and clinical relevance of which is largely unknown. In 20 orthotopic liver transplantations, we studied the occurrence and systemic effects of hyperfibrinolysis. Severe fibrinolysis was defined to be present when the euglobulin-clot lysis time and the whole-blood-clot lysis time, as measured by thrombelastography, were shorter than 60 and 90 min, respectively, at some time during the operation. Based on these criteria, 7 patients had minimal fibrinolysis (group I), and 13 patients had severe fibrinolysis (group II). In group II a gradual increase of tissue-type plasminogen activator (t-PA) activity was seen during the anhepatic stage, followed by an “explosive” increase immediately after graft reperfusion (P=0.0004, compared with group I), and a reduction of plasminogen activator inhibitor (PAI) activity. Plasma degradation products of fibrinogen and fibrin increased parallel to t-PA activity, and levels were significantly higher at 45 min after graft reperfusion in group II compared with group I (P<0.04). Thrombin-antithrombin III complexes showed an identical steady increase in both groups, indicating that increased t-PA activity was not related to thrombin formation. A combination of increased endothelial release and reduced hepatic clearance may have caused the increased t-PA activity. The t-PA—associated destruction of fibrinogen and fibrin after graft reperfusion is consistent with the clinical signs of severe oozing often seen in this period. These observations may have important clinical implications for the treatment of bleeding in patients undergoing orthotopic liver transplantation. © 1989 by The Williams and Wilkins Co