The value of 18F-FDG PET/contrast-enhanced CT in detection of tumor thrombus

PURPOSE: The differentiation between tumor and bland thromboses is important as the management differs. Retrospectively, we aim to evaluate the utility of FDG PET in detecting and differentiating tumor from bland thromboses and if FDG PET provides additional value to contrast-enhanced CT for tumor thrombus detection. PATIENTS AND METHODS: Twenty-four sites of venous thromboembolism, detected on PET/CT, were retrospectively reviewed. Classification of type of thrombosis was based on histology and radiological follow-up. We evaluated the presence of contrast-enhanced CT findings that were suggestive of tumor thrombosis; sign of invasion, neovascularity, and enhancement. Metabolic activity by means of SUV(max) was measured by drawing ROI at the site of thrombosis. Mann-Whitney U test was used to compare the mean SUV(max) between thromboses and internal references. We used ROC analysis to identify the optimal cutoff value of SUV(max) for detection of tumor thrombosis. RESULTS: Twenty-four sites of venous thromboembolism were identified in 15 patients. All tumor thromboses demonstrated at least 1 positive sign on contrast-enhanced CT, whereas 33% of bland thromboses had the same finding. The difference between tumor and bland thrombus SUV(max) was statistically significant (P < 0.005). On ROC analysis, a cutoff of SUV(max) 2.25 (sensitivity, 78%; specificity, 100%) was suggested to differentiate tumor from bland thrombosis. CONCLUSION: PET/CT is able to differentiate tumor from bland thrombosis, with an optimal cutoff value of SUV(max) 2.25. The metabolic information increases the diagnostic accuracy of tumor thrombus and is a useful adjunct to the described features on contrast-enhanced CT.postprin

Peritoneal dissemination: comparison of 18F-FDG PET/CT and DWI with conventional MRI

Scientific Formal (Paper) Presentation - SSK13: Nuclear Medicine (Oncology)PURPOSE: The purpose of this study was to evaluate the diagnostic performance of 18F-FDG PET/CT in peritoneal dissemination detection, in comparison to MRI with and without diffusion-weighted imaging (DWI). METHOD AND MATERIALS: Prospective subjects with peritoneal metastases were recruited for 18F-FDG PET/CT and MRI, performed within 4-week of each other, without intervening therapeutic interventions. Images were evaluated in separate sessions as following: DWI alone, conventional MRI alone, DWI with conventional MRI, and 18F-FDG PET/CT for peritoneal dissemination in 16 anatomical ...postprin

Peritoneal metastases evaluation: a comparison between FDG-PET/CT and MRI with correlation between SUV and ADC

Theme for ISMRM 21st Annual Meeting & Exhibition: Discovery, Innovation & Application - Advancing MR for Improved HealthTheme for SMRT 22nd Annual Meeting: Changing the World through MR Education and InnovationPURPOSE: Metastatic peritoneal malignancies are associated with advanced diseases and traditionally are considered incurable. There are, however, new medical advances using intraperitoneal chemotherapy and hyperthermic chemotherapy, which are promising in controlling local disease. Moreover, cytoreductive surgery can act as a neoadjuvant treatment to chemotherapy. With these potential effective therapies, imaging of peritoneal metastasis becomes important for surgical planning, treatment response assessment and complications monitoring. The challenge remains in evaluating peritoneal dissemination due to the large anatomical coverage and no consensus exists …postprin

Amide proton transfer MR imaging in peritoneal metastasis evaluation

Theme for ISMRM 21st Annual Meeting & Exhibition: Discovery, Innovation & Application - Advancing MR for Improved HealthTheme for SMRT 22nd Annual Meeting: Changing the World through MR Education and InnovationPURPOSE: Cytoreductive surgery has emerged as a neoadjuvant treatment to intraperitoneal and hyperthermic chemotherapy, which are potentially effective in controlling local disease. Therefore evaluation of peritoneal dissemination is essential for early diagnosis and treatment planning. MRI has been used in peritoneal metastasis imaging, with gadolinium-enhanced MRI sensitive in depicting peritoneal disseminations of small volume. CEST MRI is a novel molecular imaging technique that is able to assess the concentration of mobile proteins and peptides indirectly through bulk water signals. CEST MRI using amide protons as contrast agent, term…published_or_final_versio

Bone marrow uptake of indolent non-Hodgkin lymphoma on PET/CT with histopathological correlation

postprin

Metabolic Phenotype of Stage IV Lung Adenocarcinoma: relationship with epidermal growth factor receptor mutation

postprin

Evaluation of cervical cancer and normal cervix based on intravoxel incoherent motion imaging model-preliminary experience

This journal suppl. entitled: Book of Abstracts ESMRMB 2013 (e-only)Session - Female MRI: Let‘s take it to the next phase!PURPOSE/INTRODUCTION: We aim to investigate the differences between cervical cancer (CC) and normal cervix (NC) using intravoxel incoherent motion imaging (IVIM). SUBJECTS AND METHODS: Six patients with CC were prospectively recruited to undergo pre-treatment IVIM and routine MRI on a 3.0-T MRI. IVIM was performed ...postprin

Overprotection and the psychological states of cerebral palsy patients and their caretakers in Hong Kong: A preliminary report

Objective: To examine the relation between perceived overprotection and the psychological states of cerebral palsy patients and their primary caretakers in Hong Kong. Design: Cross-sectional survey, in which data of 14 pairs of cerebral palsy patients and their caretakers were analysed. Setting: Duchess of Kent Children's Hospital, Hong Kong. Participants: Cerebral palsy patients and their primary caretakers in Hong Kong. Main outcome measures: Perceived overprotection and psychological states. Results: Nearly two thirds of the 14 patients (mean age of 15 years) and 86% of the 14 primary caretakers (mean age of 47 years) perceived various levels of overprotection. For both patients and caretakers, perceived overprotection was positively associated with anxiety and unhappiness. The patients' and caretakers' psychological states and perception of overprotection were not related to the actual motor ability of the patients. Perceived overprotection of the patients was not related to that of the caretakers. Conclusion: Caretakers should be mindful that a well-meaning move may have undesirable consequences. More support and child-rearing education should be considered for caretakers.published_or_final_versio

Cytotoxic T lymphocytes that recognize decameric peptide sequences of retinoblastoma binding protein 1 (RBP-1) associated with human breast cancer

Retinoblastoma binding protein 1 (RBP-1) is a 143-kDa nuclear phosphoprotein that promotes cell growth by inhibiting the product of retinoblastoma tumour suppressor gene (pRB). We recently found that RBP-1 contains KASIFLK, a heptameric peptide (250–256) recognized by human antibodies and overexpressed by breast cancer cells. In the present study, we demonstrate that human T-cells stimulated with RBP-1 decameric peptides containing KASIFLK can kill human breast cancer cells. These decamers, GLQKASIFLK (247–256) and KASIFLKTRV (250–259), have anchor motifs for both HLA-A2 and HLA-A3. Peripheral blood lymphocytes from 41 normal donors were stimulated by these peptides in culture media containing 15 IU ml−1 interleukin-2, 25 IU ml−1 interleukin-7 and 500 IU ml−1 granulocyte–macrophage colony-stimulating factor. Cytotoxic activity of the T-cells was assessed against autologous B lymphoblastoid cells pulsed with each peptide. Stimulation by GLQKASIFLK generated specific cytotoxic T lymphocyte (CTL) lines from HLA-A2, A3 donors, HLA-A2 donors and HLA-A3 donors. Stimulation with KASIFLKTRV generated specific CTL lines from HLA-A2 donors. No HLA-A2−, A3− CTL line showed specific cytotoxicity against these target cells. These CTL lines were also cytotoxic against HLA-A2 and HLA-A3 breast cancer cells but not against normal fibroblastoid cell lines, normal epidermal cell lines, or a melanoma cell line. RBP-1 peptide antigens may be of clinical significance as a potential peptide vaccine against human breast cancer. © 1999 Cancer Research Campaig

Histological Evaluation of Diabetic Neurodegeneration in the Retina of Zucker Diabetic Fatty (ZDF) Rats

In diabetes, retinal dysfunctions exist prior to clinically detectable vasculopathy, however the pathology behind these functional deficits is still not fully established. Previously, our group published a detailed study on the retinal histopathology of type 1 diabetic (T1D) rat model, where specific alterations were detected. Although the majority of human diabetic patients have type 2 diabetes (T2D), similar studies on T2D models are practically absent. To fill this gap, we examined Zucker Diabetic Fatty (ZDF) rats - a model for T2D - by immunohistochemistry at the age of 32 weeks. Glial reactivity was observed in all diabetic specimens, accompanied by an increase in the number of microglia cells. Prominent outer segment degeneration was detectable with changes in cone opsin expression pattern, without a decrease in the number of labelled elements. The immunoreactivity of AII amacrine cells was markedly decreased and changes were detectable in the number and staining of some other amacrine cell subtypes, while most other cells examined did not show any major alterations. Overall, the retinal histology of ZDF rats shows a surprising similarity to T1D rats indicating that despite the different evolution of the disease, the neuroretinal cells affected are the same in both subtypes of diabetes