Polymorphism In Lep And Lepr May Modify Leptin Levels And Represent Risk Factors For Thyroid Cancer

Purpose. To understand the role of polymorphisms in the LEP (rs7799039 and rs2167270) and LEPR (rs1137101 and rs1137100) genes in DTC susceptibility and their effect on leptin levels. Methods. We studied 153 patients with DTC and 234 controls through TaqMan SNP Genotyping and ELISA, comparing these data to the clinicopathological data of patients with DTC. Results. Patients with AA genotype of rs7799039 had higher levels of serum leptin (9.22 ± 0.98 ng/mL) than those with AG genotype (10.07 ± 0.60 ng/mL; P = 0.005). Individuals with AG genotype of rs2167270 also produced higher serum leptin levels (10.05 ± 0.59 ng/mL) than the subjects with GG genotype (9.52 ± 0.79 ng/mL; P A) polymorphism and disease susceptibility and cardiovascular disease in patients with rheumatoid arthritis (2011) Clinical and Experimental Rheumatology, 29 (2), pp. 293-298Jiang, Y., Wilk, J.B., Borecki, I., Common variants in the 5' region of the leptin gene are associated with bodymass index in men fromthe National Heart, Lung, and Blood Institute Family Heart Study (2004) The American Journal of Human Genetics, 75 (2), pp. 220-230He, J., Xi, B., Ruiter, R., Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: Evidence froma meta-analysis (2013) PLoS ONE, 8 (10)Furusawa, T., Naka, I., Yamauchi, T., The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders (2010) Human Genetics, 127 (3), pp. 287-294Saukko, M., Kesäniemi, Y.A., Ukkola, O., Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis (2010) Metabolic Syndrome and Related Disorders, 8 (5), pp. 425-430Lucas, A., Granada, M.L., Olaizola, I., Leptin and thyrotropin relationship is modulated by smoking status in euthyroid subjects (2013) Thyroid, 23 (8), pp. 964-970Duntas, L.H., Biondi, B., The interconnections between obesity, thyroid function, and autoimmunity: Themultifold role of leptin (2013) Thyroid, 23 (6), pp. 646-653Marzullo, P., Minocci, A., Tagliaferri, M.A., Investigations of thyroid hormones and antibodies in obesity: Leptin levels are associated with thyroid autoimmunity independent of bioanthropometric, hormonal, and weight-related determinants (2010) Journal of Clinical Endocrinology and Metabolism, 95 (8), pp. 3965-3972Guzel, S., Seven, A., Guzel, E.C., Buyuk, B., Celebi, A., Aydemir, B., Visfatin, leptin, and TNF-α: Interrelated adipokines in insulin-resistant clinical and subclinical hypothyroidism (2013) Endocrine Research, 38 (3), pp. 184-194Mammès, O., Betoulle, D., Aubert, R., Herbeth, B., Siest, G., Fumeron, F., Association of the G-2548A polymorphism in the 5' region of the LEP gene with overweight (2000) Annals of Human Genetics, 64 (5), pp. 391-394Portoles, O., Sorli, J.V., Frances, F., Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain (2006) European Journal of Epidemiology, 21 (8), pp. 605-612Liu, C., Liu, L., Polymorphisms in three obesity-related genes (LEP, LEPR, and PON1) and breast cancer risk: A metaanalysis (2011) Tumour Biology, 32 (6), pp. 1233-1240Hoffsted, J., Eriksson, P., Mottagui-Tabar, S., Arner, P., A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin (2002) Hormone and Metabolic Research, 34 (7), pp. 355-359Murugesan, D., Arunachalam, T., Ramamurthy, V., Subramanian, S., Association of polymorphisms in leptin receptor gene with obesity and type 2 diabetes in the local population of Coimbatore (2010) Indian Journal of Human Genetics, 16 (2), pp. 72-77Quinton, N.D., Lee, A.J., Ross, R.J.M., Eastell, R., Blakemore, A.I.F., A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fatmass and leptin levels in postmenopausal Caucasian women (2001) Human Genetics, 108 (3), pp. 233-236Mattevi, V.S., Zembrzuski, V.M., Hutz, M.H., Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil (2002) International Journal of Obesity, 26 (9), pp. 1179-1185Yiannakouris, N., Yannakoulia, M., Melistas, L., Chan, J.L., Klimis-Zacas, D., Mantzoros, C.S., TheQ223Rpolymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of bodyweight and body composition variability (2001) Journal of Clinical Endocrinology and Metabolism, 86 (9), pp. 4434-4439Stefan, N., Vozarova, B., Del Parigi, A., The Gln223Arg polymorphism of the leptin receptor in Pima Indians: Influence on energy expenditure, physical activity and lipid metabolism (2002) International Journal of Obesity, 26 (12), pp. 1629-1632Chiu, K.C., Chu, A., Chuang, L.-M., Saad, M.F., Association of leptin receptor polymorphism with insulin resistance (2004) European Journal of Endocrinology, 150 (5), pp. 725-729Chu, A., Chuang, L.M., Saad, M., Chiu, K., Association of the Q223R polymorphism of the leptin receptor gene with insulin resistance and metabolic syndrome (2003) Diabetes, 52, p. 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Regional Cbf Changes In Parkinson's Disease: The Importance Of Functional Neuroimaging Analyses

[No abstract available]34914551457Tolosa, E., Wenning, G., Poewe, W., The diagnosis of Parkinson's disease (2006) Lancet Neurol, 5, pp. 75-86Hsu, J.L., Jung, T.P., Hsu, C.Y., Hsu, W.C., Chen, Y.K., Duann, J.R., Regional CBF changes in Parkinson's disease: A correlation with motor dysfunction (2007) Eur J Nucl Med Mol Imaging, , DOI 10.1007/s00259-006-0360-7Sawada, H., Udaka, F., Kameyama, M., Seriu, N., Nishinaka, K., Shindou, K., SPECT findings in Parkinson's disease associated with dementia (1992) J Neurol Neurosurg Psychiatry, 55, pp. 960-963Matsui, H., Udaka, F., Miyoshi, T., Hara, N., Tamura, A., Oda, M., N-isopropyl-p-123I iodoamphetamine single photon emission computed tomography study of Parkinson's disease with dementia (2005) Intern Med, 44, pp. 1046-1050Liu, R.S., Lin, K.N., Wang, S.J., Shan, D.E., Fuh, J.L., Yeh, S.H., Cognition and 99Tcm-HMPAO SPECT in Parkinson's disease (1992) Nucl Med Commun, 13, pp. 744-748Antonini, A., De Notaris, R., Benti, R., De Gaspari, D., Pezzoli, G., Perfusion ECD/SPECT in the characterization of cognitive deficits in Parkinson's disease (2001) Neurol Sci, 22, pp. 45-46Derejko, M., Slawek, J., Wieczorek, D., Brochhuis, B., Dubaniewicz, M., Lass, P., Regional cerebral blood flow in Parkinson's disease as an indicator of cognitive impairment (2006) Nucl Med Commun, 27, pp. 945-951Firbank, M.J., Colloby, S.J., Burn, D.J., McKeith, I.G., O'Brien, J.T., Regional cerebral blood flow in Parkinson's disease with and without dementia (2003) Neuroimage, 20, pp. 1309-1319Mito, Y., Yoshida, K., Yabe, I., Makino, K., Hirotani, M., Tashiro, K., Brain 3D-SSP SPECT analysis in dementia with Lewy bodies, Parkinson's disease with and without dementia, and Alzheimer's disease (2005) Clin Neurol Neurosurg, 107, pp. 396-403Feigin, A., Antonini, A., Fukada, M., De Notaris, R., Benti, R., Pezzoli, G., Tc-99m ethylene cysteinate dimer SPECT in the differential diagnosis of parkinsonism (2002) Mov Disord, 17, pp. 1265-1270Bosman, T., Van Laere, K., Santens, P., Anatomically standardised 99mTc-ECD brain perfusion SPECT allows accurate differentiation between healthy volunteers, multiple system atrophy and idiopathic Parkinson's disease (2003) Eur J Nucl Med Mol Imaging, 30, pp. 16-24Markus, H.S., Costa, D.C., Lees, A.J., HMPAO SPECT in Parkinson's disease before and after levodopa: Correlation with dopaminergic responsiveness (1994) J Neurol Neurosurg Psychiatry, 57, pp. 180-185Imon, Y., Matsuda, H., Ogawa, M., Kogure, D., Sunohara, N., SPECT image analysis using statistical parametric mapping in patients with Parkinson's disease (1999) J Nucl Med, 40, pp. 1583-158

Scintigraphic Findings Of Dysplasia Epiphysealis Hemimelica: A Case Report

Dysplasia epiphysealis hemimelica, a rare congenital growth disorder of the tarsus, was diagnosed radiographically in an 11-year-old boy with pain and a palpable hard mass in the medial aspect of his left ankle. Bone scintigraphy, performed after the intravenous injection of 481 MBq (13 mCi) Tc-99m MDP, showed markedly increased uptake in the medial aspect of the left ankle, and this uptake was comparable to that of the distal tibial growth plates. Dysplasia epiphysealis hemimelica is an osteocartilaginous overgrowth of one or more epiphyses or tarsal or carpal bones, involving either the medial or the lateral portion of the ossification center. Once dysplasia epiphysealis hemimelica is diagnosed, a skeletal survey is performed to check for other sites of involvement. Bone scintigraphy proved useful in the detection of dysplasia epiphysealis hemimelica and may be of great value because it can evaluate the entire skeleton with a radiation dose that is much lower than that needed for a skeletal survey.262162Azouz, E.M., Slomic, A.M., Marton, D., The variable manifestations of dysplasia epiphysealis hemimelica (1985) Pedriatr Radiol, 15, p. 44Carlson, D.H., Wilkinson, R.H., Variability of unilateral epiphyseal dysplasia (dysplasia epiphysealis hemimelica) (1979) Radiology, 133, p. 369Kuo, R.S., Bellemore, M.C., Monsell, F.P., Dysplasia epiphysealis hemimelica: Clinical features and management (1998) J Pediatr Orthop, 18, p. 543Keret, D., Spatz, D.K., Caro, P.A., Dysplasia epiphysealis hemimelica: Diagnosis and treatment (1992) J Pediatr Orthop, 12, p. 365Charron, M., Brown, M.L., Primary and metastatic bone disease (1996), p. 649. , Sandler MP, Coleman RE, Wackers FJT, et al., eds. Diagnostic Nuclear Medicine, 3rd ed. Baltimore: Williams & Wilkin