Association of plasma viscosity with cardiovascular risk factors in obesity: As an old marker, a new insight

\Although obesity is related with cardiovascular disease, the exact mechanism of the relationship is not fully understood. We aim to examine the relationship between plasma viscosity and obesity as a cardiovascular disease risk factor in obese and non-obese groups. We recruited 75 obese subjects who were admitted to the Cerrahpasa Medical Faculty. Plasma viscosity and lipid profile were measured and atherogenic index was calculated as atherogenic risk factors. Plasma viscosity, total cholesterol and LDL-cholesterol levels and atherogenic index were significantly increased in obese group compared to non-obese group for each. Plasma viscosity was weakly correlated with total cholesterol and atherogenic index only in the obese group. Plasma viscosity, an early atherosclerotic risk factor, might be helpful in the assessment of cardiovascular risk in obese subjects

Association of plasma viscosity with cardiovascular risk factors in obesity: An old marker, a new insight

Objective: Although obesity is related with cardiovascular disease, the exact mechanism of the relationship is not fully understood. We aim to examine the relationship between plasma viscosity and obesity as a cardiovascular disease risk factor in obese and non-obese groups. Methods: We recruited 75 obese subjects (mean age: 40.2 +/- 8.4 years, Body Mass Index: 33.61 +/- 2.57 kg/m(2)) who were admitted to the Clinic of Endocrinology and Metabolism of Cerrahpasa Medical Faculty. As a non-obese group (n=70, mean age: 41.78 +/- 9.7 years, Body Mass Index: 21.84 +/- 3.42 kg/m(2)) healthy subjects from medical and laboratory staff were selected. Plasma viscosity and lipid profile were measured and atherogenic index was calculated as atherogenic risk factors. Results: Plasma viscosity, total cholesterol and LDL-cholesterol levels and atherogenic index were significantly increased in obese group compared to non-obese group for each p < 0.001. We found no significant difference in plasma fibrinogen, insulin, albumin and HDL-cholesterol levels between obese and non-obese groups. Plasma viscosity was correlated with total cholesterol and atherogenic index only in the obese group (p < 0.05 and p < 0.05 respectively). In the non-obese group regarding PV, we determined a positive correlation with triglycerides (r: 0.470, p < 0.05) and negative correlation with HDL-C (r: -0.518, p < 0.05). Conclusion: Plasma viscosity, an early atherosclerotic risk factor, might be helpful in the assessment of cardiovascular risk in obese subjects along with classical cardiovascular risk factors such as plasma cholesterol and atherogenic index

Evaluation of thyroid nodules in Turkish population

Objective To determine the characteristics of thyroid nodules by using fine needle aspiration (FNA) biopsy and ultrasonography

Investigation of microalbuminuria in nondiabetic, normotensive obese women

Aim To investigate if obesity which is not accompanied by diabetes and/or hypertension is associated with microalbuminuria in female patients

Serum IGF-1 and IGFBP-3 levels in subclinical hypothyroid women

Thyroid status is known to influence growth in mammals. The aim of this study is to investigate the possible relationship between autoimmune subclinical hypothyroidism and growth hormone (GH), insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-3(IGFBP-3) levels. Thirty-five women with autoimmune subclinical hypothyroidism, 33 years of age, were used as controls and enrolled in the study. Free triiodothyronin (FT3), free thyroxin(FT4), thyrotropin(TSH), anti-thyroid peroxidase(Anti-TPO), anti-thyroglobuline(Anti-Tg), GH, IGF-1 and IGFBP-3 levels were measured in blood samples and correlations among these parameters were evaluated. We found no significant differences in GH, IGF-1 or IGFBP-3 between patients and controls. In patients and controls, there were no correlations among thyroid hormones and IGF-1 or IGFBP-3 levels, but GH levels were correlated with FT3, FT4 and TSH only in patients' group. In controls, only IGF-1 and IGFBP-3 levels were correlated. The present study suggests that subclinical hypothyroidism with high TSH and antibody status does not affect IGF-1 and IGFBP-3 levels in adult women. To our knowledge, this is the first study concerning the relationship between autoimmune subclinical hypothyroidism and IGF-1 and IGFBP-3 levels