INVESTIGATION OF THE ANTI-TUMOR EFFECTS OF BEVACIZUMAB ON GLIOBLASTOMA CELLS

Aim: Glioblastoma multiforme (GBM) is the most malignant glial tumor. Angiogenesis which provides nutrient and oxygen support to proliferating cells plays an essential role in GBM development, proliferation, and metastasis. The development of antiangiogenetic agents is a promising treatment approach as blood vessels are essential for the vitality of tumor cells. For this purpose, in this study, the effects of bevacizumab on cell viability and apoptosis were analyzed using glioblastoma cells

The Effect of Mitochondrial DNA Mutations in Brain Tumors

Purpose: Brain tumors are a group of diseases in which different genotypes result in different phenotypes at the molecular level. Although there have been a number of studies related to the role of alterations in nuclear genes, such as oncogenes and tumor suppressor genes, in the development of brain tumors, the effects of mitochondrial genes on tumorigenesis have not been well elucidated

Glioblastoma stem cells: a therapeutic challenge

The outcome for glioblastoma patients remains extremely poor, despite the advances in surgical and medical fields. It is hypothesized that glioblastoma progression, as well as tumor recurrence, is driven by a small number of cells called cancer stem cells (CSCs), which are characterized by their ability of self-renewal and proliferation, giving rise to progeny of transformation into multiple neuroepithelial lineages. Understanding the biology of CSCs is likely to explain why existing treatment strategies fail to affect the relatively quiescent and resistant CSC compartment. Here, we review the current knowledge on CSCs in glial tumors. In addition, we discuss the importance of the CSC hypothesis in the advancement of therapies for brain tumors