Parental health limitations, caregiving and loneliness among women with widowed parents: longitudinal eveidence from France

We investigate how daughters’ feelings of loneliness are impacted when widowed parents develop health limitations, and when daughters take on personal care tasks in response. Using longitudinal data from daughters of widowed parents drawn from the French Family and Intergenerational Relationships Study (ERFI, 1485 observations nested in 557 daughters), we assess (a) whether health limitations of widowed parents are associated with daughters’ feelings of loneliness regardless of whether or not daughters provide personal care and (b) whether there is an effect of care provision on loneliness that cannot be explained by parental health limitations. Fixed effect regression analyses show that widowed parents’ health limitations were associated with raised feelings of loneliness among their daughters. No significant additional effect of providing personal care to a widowed parent was found. Prior research on the impact of health limitations of older parents on the lives of their adult–children has focused mostly on issues related to informal caregiving. Our findings suggest that more attention to the psychosocial impact of parental health limitations—net of actual caregiving—on adult children’s lives is warranted

Targeted therapies in colorectal cancer: an integrative view by PPPM

In developed countries, colorectal cancer (CRC) is the third most common malignancy, but it is the second most frequent cause of cancer-related death. Clinicians are still faced with numerous challenges in the treatment of this disease, and future approaches which target the molecular features of the disorder will be critical for success in this disease setting. Genetic analyses of many solid tumours have shown that up to 100 protein-encoding genes are mutated. Within CRC, numerous genetic alterations have been identified in a number of pathways. Therefore, understanding the molecular pathology of CRC may present information on potential routes for treatment and may also provide valuable prognostic information. This will be particularly pertinent for molecularly targeted treatments, such as anti-vascular endothelial growth factor therapies and anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapy. KRAS and BRAF mutations have been shown to predict response to anti-EGFR therapy. As EGFR can also signal via the phosphatidylinositol 3-kinase (PI3K) kinase pathway, there is considerable interest in the potential roles of members of this pathway (such as PI3K and PTEN) in predicting treatment response. Therefore, a combined approach of new techniques that allow identification of these biomarkers alongside interdisciplinary approaches to the treatment of advanced CRC will aid in the treatment decision-making process and may also serve to guide future therapeutic approaches

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment

Acidentes de trabalho com mototaxistas Occupational accidents among mototaxi drivers

A utilização da motocicleta como meio de trabalho vem contribuindo para o aumento no número dos acidentes de trânsito e se constituindo em acidentes de trabalho para os mototaxistas. O objetivo deste estudo foi estimar a incidência anual de acidentes de trabalho entre mototaxistas cadastrados em Feira de Santana, BA. Trata-se de um estudo de caráter descritivo e censitário. Foram entrevistados 267 profissionais dos 300 cadastrados na Secretaria Municipal de Transporte e Trânsito - SMTT, através de questionário estruturado. Procedeu-se à análise descritiva e foram estimadas incidências anuais de acidentes de trabalho segundo as variáveis de interesse. Calcularam-se os riscos relativos e, como medida de significância estatística, utilizou-se o teste de qui-quadrado de Pearson e o teste exato de Fisher, adotando-se p < 0,05. Utilizou-se a regressão logística no intuito de realizar a análise simultânea das variáveis estudadas. Observou-se uma incidência anual de acidentes de trabalho de 10,5%. Ocorreram lesões leves, principalmente ferimentos (48,7%), sendo necessário afastamento das atividades laborais para 27% dos profissionais. Na análise de regressão logística verificou-se associação entre quantidade de dias de trabalho por semana, presença de fadiga em membros inferiores e queixa musculoesquelética e os acidentes de trabalho. O conhecimento acerca das condições de trabalho e dos acidentes envolvidos nessa atividade pode ser de grande importância para a adoção de políticas de educação no trânsito, com vistas à prevenção de acidentes e melhoria das condições de trabalho e de vida desses profissionais.<br>The use of motorcycles as a means of work has contributed to the increase in traffic accidents, in particular, mototaxi accidents. The aim of this study was to estimate and characterize the incidence of occupational accidents among the mototaxis registered in Feira de Santana, BA. This is a cross-sectional study with descriptive and census data. Of the 300 professionals registered at the Municipal Transportation Service, 267 professionals were interviewed through a structured questionnaire. Then, a descriptive analysis was conducted and the incidence of accidents was estimated based on the variables studied. Relative risks were calculated and statistical significance was determined using the chi-square test and Fisher's exact test, considering p < 0.05. Logistic regression was used in order to perform simultaneous adjustment of variables. Occupational accidents were observed in 10.5% of mototaxis. There were mainly minor injuries (48.7%), 27% of them requiring leaves of absence from work. There was an association between the days of work per week, fatigue in lower limbs and musculoskeletal complaints, and accidents. Knowledge of the working conditions and accidents involved in this activity can be of great importance for the adoption of traffic education policies, and to help prevent accidents by improving the working conditions and lives of these professionals