9 research outputs found
On a class of integrable systems with a quartic first integral
31 pages, no figureInternational audienceWe generalize, to some extent, the results on integrable geodesic flows on two dimensional manifolds with a quartic first integral in the framework laid down by Selivanova and Hadeler. The local structure is first determined by a direct integration of the differential system which expresses the conservation of the quartic observable and is seen to involve a finite number of parameters. The global structure is studied in some details and leads to a class of models living on the manifolds S^2, H^2 or R^2. As special cases we recover Kovalevskaya's integrable system and a generalization of it due to Goryachev
Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis
Hypervirulent Mycobacterium tuberculosis strain triggers necrotic lung pathology associated with enhanced recruitment of neutrophils in resistant C57BL/6 mice
Virulence-Dependent Alterations in the Kinetics of Immune Cells during Pulmonary Infection by Mycobacterium tuberculosis
The introduction of mesenchymal stromal cells induces different immunological responses in the lungs of healthy and M. tuberculosis infected mice
Myeloid-Derived Suppressor Cells (MDSCs) in Aged Mice: Focus on Inflammation
As people get older, the homeostatic functions of many systems in the body like the immune system decline, which contributes to increase susceptibility to disease. The bone marrow of healthy individuals continually generates myeloid cells, which differentiate into mature cells like granulocytes, macrophages, or dendritic cells. However, under inflammatory conditions, there is an increased frequency of immature myeloid cells that can suppress T cell responses in peripheral secondary lymph organs in both human and murine hosts. The heterogeneous population of cells known as myeloid-derived suppressor cells (MDSCs), consisting of myeloid progenitors and immature myeloid cells, share a biological function: immunosuppression. This chapter reviews novel findings in mice about the nature of MDSCs and, in this context, discusses current knowledge about these cells during the aging process. MDSCs may have an important role in the regulation of the immune response during aging. MDSC dysfunction in aged mice may compromise the innate and adaptive immune systems, and thus understanding their role during aging may be useful for potential future therapeutics.Fil: Pistoresi, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Harman, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Castell, Sofía Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentin