18 research outputs found
Neutrophils in cancer: neutral no more
Neutrophils are indispensable antagonists of microbial infection and facilitators of wound healing. In the cancer setting, a newfound appreciation for neutrophils has come into view. The traditionally held belief that neutrophils are inert bystanders is being challenged by the recent literature. Emerging evidence indicates that tumours manipulate neutrophils, sometimes early in their differentiation process, to create diverse phenotypic and functional polarization states able to alter tumour behaviour. In this Review, we discuss the involvement of neutrophils in cancer initiation and progression, and their potential as clinical biomarkers and therapeutic targets
Variable expression of the ssb-1 allele in different strains of Escherichia coli K12 and B: Differential suppression of its effects on DNA replication, DNA repair and ultraviolet mutagenesis
Are microbial communities in green roof substrates comparable to those in post-industrial sites?—a preliminary study.
Green roofs have been implemented on new buildings as a tool to
mitigate the loss of post-industrial or brownfield land. For this to be
successful, the roofs must be designed appropriately; that is with the
right growing media, suitable substrate depth, similar vegetation
and with a comparable soil microbial community for a healthy
rhizosphere. This study compared soil microbial communities
(determined using phospholipid fatty acid or PLFA analysis) of two
extensive green roofs and two post-industrial sites in Greater
London. It was found that green roof rootzones constructed using
engineered growing media are not depauperate, but can have an
abundant soil microbial community that in some cases may be
more diverse and numerous than communities found in brownfield
areas. In this preliminary study, one green roof supported abundant
soil microbial communities that were dominated by gram negative
and aerobic bacteria, whilst fungal abundance was similar across all
sites analysed. Furthermore, ratios of fungal: bacterial PLFA’s were
larger from post-industrial sites but overall were consistent with
bacterial dominated soils typical of early successional habitats