28 research outputs found
Pancreatic Allograft Thrombosis: Suggestion for a CT grading system and management algorithm
Pancreatic allograft thrombosis (PAT) remains the leading cause of non-immunological graft failure. Herein we propose a new CT grading system of PAT to identify risk factors for allograft loss and outline a management algorithm by retrospective review of consecutive pancreatic transplants between 2009-2014. Triple-phase CT scans were graded independently by two radiologists as; Grade 0 – no thrombosis, Grade 1 – peripheral thrombosis, Grade 2 – intermediate non-occlusive thrombosis and Grade 3 – central occlusive thrombosis. Twenty-four of 103 (23.3%) recipients were diagnosed with PAT (including grade 1). Three grafts (2.9%) were lost due to portal vein thrombosis. On multivariate analysis, pancreas after SPK/PAK transplant, acute rejection and CT finding peri-pancreatic oedema and/or inflammatory change were significant risk factors of PAT. Retrospective review of CT images revealed more grade 1 and 2 thromboses than were initially reported. There was no significant difference in graft or patient survival, post-operative stay or morbidity of recipients with grade 1 or 2 thrombosis who were or were not anticoagulated. Our data suggest that therapeutic anticoagulation is not necessary for grade 1 and 2 arterial and grade 1 venous thrombosis. The proposed grading system can assist clinicians in decision making and provide standardised reporting for future studies
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas
Summary
Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (TP53, ATRX, RB1) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. Overall, this large-scale analysis reveals previously unappreciated sarcoma-type-specific changes in copy number, methylation, RNA, and protein, providing insights into refining sarcoma therapy and relationships to other cancer types
Oral Cancer Among Patients Under the Age of 35 Years
BACKGROUND: Cancer of the oral cavity is one of the commonest cancers
among males. AIMS: To assess the aetiological factors, patient
characteristics, treatment and the outcome in young patients with oral
cancer. SETTINGS AND DESIGN: A retrospective descriptive study of
patients under the age of 35 years with cancer of the oral cavity
treated between 1982-1996, with the last follow-up till 2001, using the
tumour registry data of Regional Cancer Centre (RCC), Trivandrum,
Kerala, India. SUBJECT AND METHOD: The detailed clinical, treatment and
follow-up data were obtained from the computerised records of RCC and
recorded on a preset proforma. This was analysed with emphasis on age,
sex, risk factors, site, histology, clinical extent and treatment
methods and survival in the study group. STATISTICAL ANALYSIS: The
survival analysis was carried by Kaplan-Meier method and the difference
in survival was analysed using log-rank test. RESULTS: Out of 264
patients analysed, tongue was the commonest site identified in 136
(52%) patients followed by buccal mucosa in 69 (26%) patients. A male
female ratio of 2.3:1 was observed with a significantly higher male
preponderance in buccal mucosa (4.3:1). Prior exposure to tobacco or
alcohol was noted in 59.4% patients, with more habitu\ue9s in buccal
mucosa cancer. Histological confirmation was present only in 83.7%
patients and among them most were squamous cell carcinoma (85.9%).
Radiotherapy, surgery or combined modalities of treatment were employed
for majority of patients. The 5-year survival was 57.3%. T stage of the
tumour was found to be significant in predicting disease free survival
(P=0.03). CONCLUSIONS: The importance of early detection for clinical
down staging is stressed. There is a need to investigate the aetiology
of intra oral cancers in younger patients since a significant
proportion (almost 40%) of these patients do not have associated risk
factors for cancer