Impaired phagocytosis and reactive oxygen species production in phagocytes is associated with systemic vasculitis

BACKGROUND: Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) is a group of autoimmune diseases, characterized by small vessel inflammation. Phagocytes such as neutrophils and monocytes are the main effector cells found around the inflamed vessel wall. Therefore, we wanted to investigate aspects of function and activation of these cells in patients with AAV.METHODS: Flow cytometry was used to evaluate: the expression of activation markers (CD11c, CD62L, CD177 and C5aR); the number of recently released neutrophils from bone marrow, defined as CD10(-)D16(low) cells in peripheral blood; and the capacity of peripheral blood monocytes and polymorphonuclear leukocytes (PMN) to produce reactive oxygen species and to phagocytose opsonized bacteria.RESULTS: AAV patients (n = 104) showed an increase of CD10(-)CD16(low) neutrophils and total PMN in peripheral blood, suggesting a combination of increased bone marrow release and prolonged survival. An increased percentage of AAV PMN expressed CD177 but no other signs of activation were seen. A decreased production of reactive oxygen species was observed in AAV phagocytes, which was associated with disease activity. Moreover, granulocytes from patients with microscopic polyangiitis showed lower oxidative burst capacity compared to patients with granulomatosis with polyangiitis or eosinophilic granulomatosis with polyangiitis. In addition, decreased phagocytosis capacity was seen in PMN and monocytes.CONCLUSION: Our results indicate that phagocytes from AAV patients have impaired function, are easily mobilized from bone marrow but are not particularly activated. The association between low reactive oxygen species formation in PMN and disease severity is consistent with findings in other autoimmune diseases and might be considered as a risk factor

An Approximation Algorithm for Time Optimal Multi-Robot Routing

Abstract This paper presents a polynomial time approximation algorithm for Multi-Robot Routing. The Multi-Robot Routing problem seeks to plan paths for a team of robots to visit a large number of interchangeable goal locations as quickly as possible. As a result of providing a constant factor bound on the suboptimality of the total distance any robot travels, the total completion time, or makespan, for robots to visit every goal vertex using this plan is no more than 5 times the optimal completion time. This result is significant because it provides a rigorous guarantee on time optimality, important in applications in which teams of robots carry out time-critical missions. These applications include autonomous exploration, surveillance, first response, and search and rescue.

DSD: document sparse-based denoising algorithm

International audienceIn this paper, we present a sparse-based denoising algorithm for scanned documents. This method can be applied to any kind of scanned documents with satisfactory results. Unlike other approaches, the proposed approach encodes noise documents through sparse representation and visual dictionary learning techniques without any prior noise model. Moreover, we propose a precision parameter estimator. Experiments on several datasets demonstrate the robustness of the proposed approach compared to the state-of-the-art methods on document denoising