5 research outputs found
Family History and Breast Cancer Hormone Receptor Status in a Spanish Cohort
Breast cancer is a heterogenous disease that impacts racial/ethnic groups differently. Differences in genetic composition, lifestyles, reproductive factors, or environmental exposures may contribute to the differential presentation of breast cancer among Hispanic women.A population-based study was conducted in the city of Santiago de Compostela, Spain. A total of 645 women diagnosed with operable invasive breast cancer between 1992 and 2005 participated in the study. Data on demographics, breast cancer risk factors, and clinico-pathological characteristics of the tumors were collected. Hormone receptor negative tumors were compared with hormone receptor postive tumors on their clinico-pathological characteristics as well as risk factor profiles.Among the 645 breast cancer patients, 78% were estrogen receptor-positive (ER+) or progesterone receptor-positive (PR+), and 22% were ERâ&PRâ. Women with a family history of breast cancer were more likely to have ERâ&PRâ tumors than women without a family history (Odds ratio, 1.43; 95% confidence interval, 0.91â2.26). This association was limited to cancers diagnosed before age 50 (Odds ratio, 2.79; 95% confidence interval, 1.34â5.81).An increased proportion of ERâ&PRâ breast cancer was observed among younger Spanish women with a family history of the disease