Корригирующее влияние измененной газовой среды и температуры на функциональные показатели у животных после каротидной гломэктомии

Carotid glomectomy is an adequate method for studying the functional role of peripheral chemoreceptors in the regulation of body functions. After glomectomy in animals the blood glucose level increases, respiratory rate decreases, oxygen consumption and carbon footprint signs of anaemia develops. The results suggest the possibility of physiological correction of the level of glycemia and gas exchange in animals during periodic action of hypoxia, hypo- or hyperthermia after glomectomy.Каротидная гломэктомия является адекватным методом изучения функциональной роли периферических хеморецепторов в регуляции функций организма. После гломэктомии у животных увеличивается содержание глюкозы в крови, снижается дыхательный коэффициент, потребление кислорода и выделение углекислого газа, развиваются явления анемизации. Полученные результаты свидетельствуют о возможности физиологической коррекции уровня гликемии и показателей газообмена у животных при периодическом воздействии гипоксии, гипо- или гипертермии после гломэктомии

Effect of changes in gaseous environment and temperature on animals with diabetes

In contrast to normal environmental conditions (normal temperature and gaseous composition of the atmosphere), regular exposure to hypoxia or cold for 3 weeks after carotid glomectomy does not increase blood glucose and causes no anemia or depression of gaseous and energy metabolism. Diabetogenic effect of streptozotocin after a previous hypoxic or cold exposure is associated with lower hyperglycemia; the time course of hematological and gaseous metabolism parameters after glomectomy depends on the effects of changed gaseous environment or temperature. ©1999 Kluwer Academic/Plenuin Publishers

Blood glucose, gas exchange, and hematological parameters in rats with experimental diabetes mellitus after carotid glomectomy

In glomectomized rats with denervated sinus carotid reflexogenic zones as compared with sham-operated controls, the diabetogenic action of streptozotocin was manifested by more pronounced changes in several hematological parameters, including marked elevation of blood glucose and reductions of oxygen consumption, the respiratory quotient, blood hemoglobin concentration, the hematocrit, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration. These findings attest that the carotid sinus receptors play an important functional role in producing the symptom complex of diabetes mellitus. © 1996, Plenum Publishing Corporation. All rights reserved

Functional homology in response of human cardiovascular system to hypoxia and hypercapnia under various environmental conditions

The authors studied physiologic peculiarities associated with cardiorespiratory response to hypoxia and hypercapnia in various climate and geographic conditions, to combined effects of hypoxia, hypercapnia and physical burden, in artificial atmosphere with various velocity of hypoxia and hypercapnia increase. The studies were based on a hypothesis of universal mechanism that describes regulation of gas-transporting system and is aimed to supply oxygen to the body under ecological hazards. The authors revealed similarity of circulatory and respiratory responses to hypoxia and hypercapnia in various ecological circumstances

Effects of carotid glomectomy on erythron parameters in rats differing in the resistance to acute hypoxia

Rats with low resistance to acute altitude hypoxia did not differ from those with high resistance in the erythron parameters recorded under normal environmental conditions. After a bilateral carotid glomectomy, significant falls in the red blood cell count, hemoglobin concentration, packed cell volume, and mean corpuscular hemoglobin were recorded only in the group with low resistance to acute hypoxia, although the "altitude" resistance was decreased to similar degrees in the two groups. ©1996 Plenum Publishing Corporation

Effects of carotid glomectomy on erythron parameters in rats differing in the resistance to acute hypoxia

Rats with low resistance to acute altitude hypoxia did not differ from those with high resistance in the erythron parameters recorded under normal environmental conditions. After a bilateral carotid glomectomy, significant falls in the red blood cell count, hemoglobin concentration, packed cell volume, and mean corpuscular hemoglobin were recorded only in the group with low resistance to acute hypoxia, although the "altitude" resistance was decreased to similar degrees in the two groups. ©1996 Plenum Publishing Corporation

Functional homology in response of human cardiovascular system to hypoxia and hypercapnia under various environmental conditions

The authors studied physiologic peculiarities associated with cardiorespiratory response to hypoxia and hypercapnia in various climate and geographic conditions, to combined effects of hypoxia, hypercapnia and physical burden, in artificial atmosphere with various velocity of hypoxia and hypercapnia increase. The studies were based on a hypothesis of universal mechanism that describes regulation of gas-transporting system and is aimed to supply oxygen to the body under ecological hazards. The authors revealed similarity of circulatory and respiratory responses to hypoxia and hypercapnia in various ecological circumstances