9 research outputs found
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Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis
No full textRASopathies, a family of disorders characterized by cardiac defects, defective growth, facial dysmorphism, variable cognitive deficits and predisposition to certain malignancies, are caused by constitutional dysregulation of RAS signalling predominantly t
The abundance of the ARL2 GTPase and its GAP, ELMOD2, at mitochondria are modulated by the fusogenic activity of mitofusins and stressors
No full textPlexin-Bs enhance their GAP activity with a novel activation switch loop generating a cooperative enzyme
No full textApolar and polar transitions drive the conversion between amoeboid and mesenchymal shapes in melanoma cells
No full textRapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-acyl-N-alkyl sulfonamide
No full textSpatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation
No full text
