Family-Centered Preventive Intervention for Military Families: Implications for Implementation Science

In this paper, we report on the development and dissemination of a preventive intervention, Families OverComing Under Stress (FOCUS), an eight-session family-centered intervention for families facing the impact of wartime deployments. Specific attention is given to the challenges of rapidly deploying a prevention program across diverse sites, as well as to key elements of implementation success. FOCUS, developed by a UCLA-Harvard team, was disseminated through a large-scale demonstration project funded by the United States Bureau of Navy Medicine and Surgery (BUMED) beginning in 2008 at 7 installations and expanding to 14 installations by 2010. Data are presented to describe the range of services offered, as well as initial intervention outcomes. It proved possible to develop the intervention rapidly and to deploy it consistently and effectively

MRI of the kidney—state of the art

Ultrasound and computed tomography (CT) are modalities of first choice in renal imaging. Until now, magnetic resonance imaging (MRI) has mainly been used as a problem-solving technique. MRI has the advantage of superior soft-tissue contrast, which provides a powerful tool in the detection and characterization of renal lesions. The MRI features of common and less common renal lesions are discussed as well as the evaluation of the spread of malignant lesions and preoperative assessment. MR urography technique and applications are discussed as well as the role of MRI in the evaluation of potential kidney donors. Furthermore the advances in functional MRI of the kidney are highlighted

Protein kinase C and cardiac dysfunction: a review

Heart failure (HF) is a physiological state in which cardiac output is insufficient to meet the needs of the body. It is a clinical syndrome characterized by impaired ability of the left ventricle to either fill or eject blood efficiently. HF is a disease of multiple aetiologies leading to progressive cardiac dysfunction and it is the leading cause of deaths in both developed and developing countries. HF is responsible for about 73,000 deaths in the UK each year. In the USA, HF affects 5.8 million people and 550,000 new cases are diagnosed annually. Cardiac remodelling (CD), which plays an important role in pathogenesis of HF, is viewed as stress response to an index event such as myocardial ischaemia or imposition of mechanical load leading to a series of structural and functional changes in the viable myocardium. Protein kinase C (PKC) isozymes are a family of serine/threonine kinases. PKC is a central enzyme in the regulation of growth, hypertrophy, and mediators of signal transduction pathways. In response to circulating hormones, activation of PKC triggers a multitude of intracellular events influencing multiple physiological processes in the heart, including heart rate, contraction, and relaxation. Recent research implicates PKC activation in the pathophysiology of a number of cardiovascular disease states. Few reports are available that examine PKC in normal and diseased human hearts. This review describes the structure, functions, and distribution of PKCs in the healthy and diseased heart with emphasis on the human heart and, also importantly, their regulation in heart failure

MHD Simulations of Magnetized Stars in the Propeller Regime of Accretion

Accreting magnetized stars may be in the propeller regime of disc accretion in which the angular velocity of the stellar magnetosphere exceeds that of the inner disc. In these systems, the stellar magnetosphere acts as a centrifugal barrier and inhibits matter accretion onto the rapidly rotating star. Instead, the matter accreting through the disc accumulates at the disc-magnetosphere interface where it picks up angular momentum and is ejected from the system as a wide-angled outflow which gradually collimates at larger distances from the star. If the ejection rate is lower than the accretion rate, the matter will accumulate at the boundary faster than it can be ejected; in this case, accretion onto the star proceeds through an episodic accretion instability in which the episodes of matter accumulation are followed by a brief episode of simultaneous ejection and accretion of matter onto the star. In addition to the matter dominated wind component, the propeller outflow also exhibits a well-collimated, magnetically-dominated Poynting jet which transports energy and angular momentum away from the star. The propeller mechanism may explain some of the weakly-collimated jets and winds observed around some T Tauri stars as well as the episodic variability present in their light curves. It may also explain some of the quasi-periodic variability observed in cataclysmic variables, millisecond pulsars and other magnetized stars