24 research outputs found
Breast cancer survival among young women: a review of the role of modifiable lifestyle factors
The Effect of Molecular Subtype and Residual Disease on Locoregional Recurrence in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy and Postmastectomy Radiation
Postmastectomy radiotherapy benefit in Chinese breast cancer patients with T1–T2 tumor and 1–3 positive axillary lymph nodes by molecular subtypes: an analysis of 1369 cases
RNA editing produces glycine receptor α3P185L, resulting in high agonist potency
The function of supramedullary glycine receptors (GlyRs) is still unclear. Using Wistar rat collicular slices, we demonstrate GlyR-mediated inhibition of spike discharge elicited by low glycine (10 μM). Searching for the molecular basis of this phenomenon, we identified a new GlyR isoform. GlyRα3 P185L, a result of cytidine 554 deamination, confers high glycine sensitivity (EC50 ∼5 μM) to neurons and thereby promotes the generation of sustained chloride conductances associated with tonic inhibition. The level of GlyRα3-C554U RNA editing is sensitive to experimentally induced brain lesion, inhibition of cytidine deamination by zebularine and inhibition of mRNA transcription by actinomycin D, but not to blockade of protein synthesis by cycloheximide. Conditional regulation of GlyRα3 P185L is thus likely to be part of a post-transcriptional adaptive mechanism in neurons with enhanced excitability. © 2005 Nature Publishing Group