The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

The publisher's final edited version of this article is available at Oncogene. 2018 Oct;37(40):5435-5450. doi: 10.1038/s41388-018-0315-z. Epub 2018 Jun 5. Non-commercial use onlyThis study was funded by Cancer Research UK, the German Research Foundation (FOR2314) and the German Cancer Aid (111917)

Developing professional identity in health professional students

Professional identity formation is a relatively new area of interest within health professional education, gaining academic attention after the Carnegie Foundation Report on Medical Education of 2010 called for its introduction into medical curricula in the United States. This chapter presents a critical discussion, introducing various schools of thought, and provides theoretically informed suggestions for practice. The authors explore both conventional identity formation and more complex modern reconfigurations of healthcare professional identity. The chapter starts with an overview of different stances on what professional identity means, drawing on a variety of literatures including sociological and organizational scholarship. Next, a range of theories of identity formation are presented, including socialization and transformation. A matrix model is introduced to inform curricular planning, which can be used flexibly within different institutions or contexts. The authors discuss and critique a number of focused strategies for educators including role modeling, mentoring, reflective practice, responding to the hidden curriculum, authentic role experiences and simulation-based education, communities of practice and activity theory, student engagement, and assessment practices. The chapter concludes with possible future directions in healthcare professional identity education. Kathleen Leedham-Green is a research fellow in the Medical Education Research Unit at Imperial College London with interests in the social and behavioral aspects of clinical practice as well as healthcare innovation and quality. Alec Knight is a postdoctoral researcher and educator at King’s College London with interests in health services research, applied psychology, medical education, public health, health policy, and implementation science. Rick Iedema is professor and director of the Centre for Team-Based Practice and Learning in Health Care at King’s College London

The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Aβ generation in vivo

The cholesterol-synthesizing enzyme seladin-1, encoded by the Dhcr24 gene, is a flavin adenine dinucleotide-dependent oxidoreductase and regulates responses to oncogenic and oxidative stimuli. It has a role in neuroprotection and is downregulated in affected neurons in Alzheimer's disease (AD). Here we show that seladin-1-deficient mouse brains had reduced levels of cholesterol and disorganized cholesterol-rich detergent-resistant membrane domains (DRMs). This was associated with inefficient plasminogen binding and plasmin activation, the displacement of β-secretase (BACE) from DRMs to APP-containing membrane fractions, increased β-cleavage of APP and high levels of Aβ peptides. In contrast, overexpression of seladin-1 increased both cholesterol and the recruitment of DRM components into DRM fractions, induced plasmin activation and reduced both BACE processing of APP and Aβ formation. These results establish a role of seladin-1 in the formation of DRMs and suggest that seladin-1-dependent cholesterol synthesis is involved in lowering Aβ levels. Pharmacological enhancement of seladin-1 activity may be a novel Aβ-lowering approach for the treatment of AD