27 research outputs found
In vitro effect of lymphoblastoid alpha-interferon on subpopulations of effector cells mediating cytotoxicity for autologous hepatocytes in hepatitis B and non-A, non-B.
Alpha-interferon enhances non-T cell cytotoxicity for autologous hepatocytes in acute and chronic HBV infection.
In vitro effect of lymphoblastoid alfa-interferon on subpopulations of effector cells mediating cytotoxicity for autologous hepatocytes in hepatitis B and non-A, non-B.
The spectrum of chronic hepatitis in the last two decades in a university hospital for infectious diseases
During the last eighteen years (1970-1987) at the Infectious Diseases Clinic of the University of Pavia, Ospedale Policlinico S. Matteo, IRCCS, Pavia (referral Center for hepatitis in our district: 502534 inhabitants) we observed 4238 patients (2706 M=63,8%; 1532 F = 36,2%) admitted with presumptive diagnosis of hepatitis. The male to female sex ratio was 1.78 and average age was 38 (1-90) years. Acute viral hepatitis was diagnosed in 3238 patients (76,4%), 1960 of which were males (60,5%) and 1278 (39,5%) females, with an average age of 35 (1-88) years. The possible route of transmission was: drug addition in 486 patients (15%), blood transfusion in 464 (14.3%), other (sexual, professionale, familiar) in 332 (10.3%), unknown in 1955 (60.4%). Chronic hepatitis (CH) was diagnosed according to the European Association for the Study of the Liver (EASL) and to the International Association for the Study of the Liver (IASL) in 848 patients (20%), 704 M (83%) and 144 F (17%) with an average age of 48 (2-90) years. 463 patients (54,5%) were biopsied durign admission, 385 (45,5%) received definitive diagnosis by clinical and previous histologic records. CAH was found in 268 (57,9%), CPH in 161 (34,8%) and CLH in 20 (4.3%) patients. Other liver diseases (steatosis, cirrhosis, HCC) were identified in 152 subjects (3%). The prevalence of A, B, NANB and Delta hepatitis virus in HI virus in the acute disease was respectively of 5.4%, 54,8%, 33,9%, 0,28% and 0,77%. In CH the HBV aetiology accounted for 49,1%, NANB virus fro 44,5%, co/super infection with HDV for 15%. Among factors involved in pathogenesis of chronic hepatitis we focused attention on drug addition which was found in 129 (28,7%) petients, blood transfusion in 70 (15,6%), HIV infection in 35 of 166 (21,1%). The data still demonstrate the high prevalence of HBV aetiology of CH and existence of co-factors in the pathogenesis of chronicity. The lack of markers of NANB infection persists as the main problem in the diagnosis of liver disease. This work was supported by grand 40% from M.P.I. "Epatiti virali acute e croniche"..
Clonal analysis and precursor frequency of HBcAg specific T lymphocytes in chronic HBV infection
Ultrasonographic and microbiological diagnosis of mycetic liver abscesses in patients with AIDS
A rare case of multiple mycetic abscesses in a patient with AIDS is reported: the diagnosis was suspected after an ultrasound (US) examination and was obtained with US guided percutaneous puncture. The US appearance and differential diagnosis of mycetic liver abscesses are discussed and the increasing role of US and US guided percutaneous puncture in the screening of these patients is stressed