A novel safety assessment strategy applied to non-selective extracts

A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult to determine. Here, a pragmatic novel safety assessment strategy is applied to the production of non-selective extracts (NSEs), used for different purposes in food such as for colouring purposes, which are complex food mixtures prepared from reference juices. The Complex Mixture Safety Assessment Strategy (CoMSAS) is an exposure driven approach enabling to efficiently assess the safety of the NSE by focussing on newly formed substances or substances that may increase in exposure during the processing of the NSE. CoMSAS enables to distinguish toxicologically relevant from toxicologically less relevant substances, when related to their respective levels of exposure. This will reduce the amount of work needed for identification, characterisation and safety assessment of unknown substances detected at low concentration, without the need for toxicity testing using animal studies. In this paper, the CoMSAS approach has been applied for elderberry and pumpkin NSEs used for food colouring purposes

The relationship between basal and induced resistance in Arabidopsis

Plants are constantly exposed to potentially pathogenic micro-organisms. They possess an extensive array of passive and active defense mechanisms, and only a small proportion of micro-organisms are capable of infecting the plant and causing disease. Plant resistance can be broadly defined as the plant's ability to suppress or retard the damaging activity of a pathogen. The most common type of resistance is nonhost resistance. This type of resistance protects the plant entirely from infection by most potential pathogens, and is manifested as an inability of the pathogen to cause disease upon contact with any individual of a particular plant species. In such an interaction, the pathogen is nonpathogenic