119 research outputs found
Spin-dependent Bohm trajectories for hydrogen eigenstates
The Bohm trajectories for several hydrogen atom eigenstates are determined,
taking into account the additional momentum term that arises from the Pauli
current. Unlike the original Bohmian result, the spin-dependent term yields
nonstationary trajectories. The relationship between the trajectories and the
standard visualizations of orbitals is discussed. The trajectories for a model
problem that simulates a 1s-2p transition in hydrogen are also examined.Comment: 11 pages, 3 figure
Interference, reduced action, and trajectories
Instead of investigating the interference between two stationary, rectilinear
wave functions in a trajectory representation by examining the two rectilinear
wave functions individually, we examine a dichromatic wave function that is
synthesized from the two interfering wave functions. The physics of
interference is contained in the reduced action for the dichromatic wave
function. As this reduced action is a generator of the motion for the
dichromatic wave function, it determines the dichromatic wave function's
trajectory. The quantum effective mass renders insight into the behavior of the
trajectory. The trajectory in turn renders insight into quantum nonlocality.Comment: 12 pages text, 5 figures. Typos corrected. Author's final submission.
A companion paper to "Welcher Weg? A trajectory representation of a quantum
Young's diffraction experiment", quant-ph/0605121. Keywords: interference,
nonlocality, trajectory representation, entanglement, dwell time, determinis
Welcher Weg? A trajectory representation of a quantum Young's diffraction experiment
The double slit problem is idealized by simplifying each slit by a point
source. A composite reduced action for the two correlated point sources is
developed. Contours of the reduced action, trajectories and loci of transit
times are developed in the region near the two point sources. The trajectory
through any point in Euclidian 3-space also passes simultaneously through both
point sources.Comment: 12 pages LaTeX2e, 9 figures. Typos corrected. Author's final
submission. A companion paper to "Interference, reduced action, and
trajectories", quant-ph/0605120. Keywords: interference, Young's experiment,
entanglement, nonlocality, trajectory representation, determinis
The Quantum Reduced Action In Higher Dimensions
The solution with respect to the reduced action of the one-dimensional
stationary quantum Hamilton-Jacobi equation is well known in the literature.
The extension to higher dimensions in the separated variable case was proposed
in contradictory formulations. In this paper we provide new insights into the
construction of the reduced action. In particular, contrary to the classical
mechanics case, we analytically show that the reduced action constructed as a
sum of one variable functions does not contain a complete information about the
quantum motion. In the same context, we also make some observations about
recent results concerning quantum trajectories. Finally, we will examine the
conditions in which microstates appear even in the case where the wave function
is complex.Comment: 12 pages, no figur
Coherent States and Modified de Broglie-Bohm Complex Quantum Trajectories
This paper examines the nature of classical correspondence in the case of
coherent states at the level of quantum trajectories. We first show that for a
harmonic oscillator, the coherent state complex quantum trajectories and the
complex classical trajectories are identical to each other. This congruence in
the complex plane, not restricted to high quantum numbers alone, illustrates
that the harmonic oscillator in a coherent state executes classical motion. The
quantum trajectories are those conceived in a modified de Broglie-Bohm scheme
and we note that identical classical and quantum trajectories for coherent
states are obtained only in the present approach. The study is extended to
Gazeau-Klauder and SUSY quantum mechanics-based coherent states of a particle
in an infinite potential well and that in a symmetric Poschl-Teller (PT)
potential by solving for the trajectories numerically. For the coherent state
of the infinite potential well, almost identical classical and quantum
trajectories are obtained whereas for the PT potential, though classical
trajectories are not regained, a periodic motion results as t --> \infty.Comment: More example
Reproductive biology of endemic Solanum melissarum Bohs (Solanaceae) and updating of its current geographic distribution as the basis for its conservation in the Brazilian Cerrado
Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury
A proportion of patients infected with severe acute respiratory syndrome coronavirus 2 experience a range of neuropsychiatric symptoms months after infection, including cognitive deficits, depression and anxiety. The mechanisms underpinning such symptoms remain elusive. Recent research has demonstrated that nervous system injury can occur during COVID-19. Whether ongoing neural injury in the months after COVID-19 accounts for the ongoing or emergent neuropsychiatric symptoms is unclear. Within a large prospective cohort study of adult survivors who were hospitalized for severe acute respiratory syndrome coronavirus 2 infection, we analysed plasma markers of nervous system injury and astrocytic activation, measured 6 months post-infection: neurofilament light, glial fibrillary acidic protein and total tau protein. We assessed whether these markers were associated with the severity of the acute COVID-19 illness and with post-acute neuropsychiatric symptoms (as measured by the Patient Health Questionnaire for depression, the General Anxiety Disorder assessment for anxiety, the Montreal Cognitive Assessment for objective cognitive deficit and the cognitive items of the Patient Symptom Questionnaire for subjective cognitive deficit) at 6 months and 1 year post-hospital discharge from COVID-19. No robust associations were found between markers of nervous system injury and severity of acute COVID-19 (except for an association of small effect size between duration of admission and neurofilament light) nor with post-acute neuropsychiatric symptoms. These results suggest that ongoing neuropsychiatric symptoms are not due to ongoing neural injury
Accelarated immune ageing is associated with COVID-19 disease severity
Background
The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convalescent immunesenescence and acute disease severity, we determined the immune phenotype of COVID-19 survivors and non-infected controls.
Results
We performed detailed immune phenotyping of peripheral blood mononuclear cells isolated from 103 COVID-19 survivors 3–5 months post recovery who were classified as having had severe (n = 56; age 53.12 ± 11.30 years), moderate (n = 32; age 52.28 ± 11.43 years) or mild (n = 15; age 49.67 ± 7.30 years) disease and compared with age and sex-matched healthy adults (n = 59; age 50.49 ± 10.68 years). We assessed a broad range of immune cell phenotypes to generate a composite score, IMM-AGE, to determine the degree of immune senescence. We found increased immunesenescence features in severe COVID-19 survivors compared to controls including: a reduced frequency and number of naïve CD4 and CD8 T cells (p < 0.0001); increased frequency of EMRA CD4 (p < 0.003) and CD8 T cells (p < 0.001); a higher frequency (p < 0.0001) and absolute numbers (p < 0.001) of CD28−ve CD57+ve senescent CD4 and CD8 T cells; higher frequency (p < 0.003) and absolute numbers (p < 0.02) of PD-1 expressing exhausted CD8 T cells; a two-fold increase in Th17 polarisation (p < 0.0001); higher frequency of memory B cells (p < 0.001) and increased frequency (p < 0.0001) and numbers (p < 0.001) of CD57+ve senescent NK cells. As a result, the IMM-AGE score was significantly higher in severe COVID-19 survivors than in controls (p < 0.001). Few differences were seen for those with moderate disease and none for mild disease. Regression analysis revealed the only pre-existing variable influencing the IMM-AGE score was South Asian ethnicity (
= 0.174, p = 0.043), with a major influence being disease severity (
= 0.188, p = 0.01).
Conclusions
Our analyses reveal a state of enhanced immune ageing in survivors of severe COVID-19 and suggest this could be related to SARS-Cov-2 infection. Our data support the rationale for trials of anti-immune ageing interventions for improving clinical outcomes in these patients with severe disease
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
Background:
Sleep disturbance is common following hospital admission both for COVID-19 and other causes. The clinical associations of this for recovery after hospital admission are poorly understood despite sleep disturbance contributing to morbidity in other scenarios. We aimed to investigate the prevalence and nature of sleep disturbance after discharge following hospital admission for COVID-19 and to assess whether this was associated with dyspnoea.
Methods:
CircCOVID was a prospective multicentre cohort substudy designed to investigate the effects of circadian disruption and sleep disturbance on recovery after COVID-19 in a cohort of participants aged 18 years or older, admitted to hospital for COVID-19 in the UK, and discharged between March, 2020, and October, 2021. Participants were recruited from the Post-hospitalisation COVID-19 study (PHOSP-COVID). Follow-up data were collected at two timepoints: an early time point 2–7 months after hospital discharge and a later time point 10–14 months after hospital discharge. Sleep quality was assessed subjectively using the Pittsburgh Sleep Quality Index questionnaire and a numerical rating scale. Sleep quality was also assessed with an accelerometer worn on the wrist (actigraphy) for 14 days. Participants were also clinically phenotyped, including assessment of symptoms (ie, anxiety [Generalised Anxiety Disorder 7-item scale questionnaire], muscle function [SARC-F questionnaire], dyspnoea [Dyspnoea-12 questionnaire] and measurement of lung function), at the early timepoint after discharge. Actigraphy results were also compared to a matched UK Biobank cohort (non-hospitalised individuals and recently hospitalised individuals). Multivariable linear regression was used to define associations of sleep disturbance with the primary outcome of breathlessness and the other clinical symptoms. PHOSP-COVID is registered on the ISRCTN Registry (ISRCTN10980107).
Findings:
2320 of 2468 participants in the PHOSP-COVID study attended an early timepoint research visit a median of 5 months (IQR 4–6) following discharge from 83 hospitals in the UK. Data for sleep quality were assessed by subjective measures (the Pittsburgh Sleep Quality Index questionnaire and the numerical rating scale) for 638 participants at the early time point. Sleep quality was also assessed using device-based measures (actigraphy) a median of 7 months (IQR 5–8 months) after discharge from hospital for 729 participants. After discharge from hospital, the majority (396 [62%] of 638) of participants who had been admitted to hospital for COVID-19 reported poor sleep quality in response to the Pittsburgh Sleep Quality Index questionnaire. A comparable proportion (338 [53%] of 638) of participants felt their sleep quality had deteriorated following discharge after COVID-19 admission, as assessed by the numerical rating scale. Device-based measurements were compared to an age-matched, sex-matched, BMI-matched, and time from discharge-matched UK Biobank cohort who had recently been admitted to hospital. Compared to the recently hospitalised matched UK Biobank cohort, participants in our study slept on average 65 min (95% CI 59 to 71) longer, had a lower sleep regularity index (–19%; 95% CI –20 to –16), and a lower sleep efficiency (3·83 percentage points; 95% CI 3·40 to 4·26). Similar results were obtained when comparisons were made with the non-hospitalised UK Biobank cohort. Overall sleep quality (unadjusted effect estimate 3·94; 95% CI 2·78 to 5·10), deterioration in sleep quality following hospital admission (3·00; 1·82 to 4·28), and sleep regularity (4·38; 2·10 to 6·65) were associated with higher dyspnoea scores. Poor sleep quality, deterioration in sleep quality, and sleep regularity were also associated with impaired lung function, as assessed by forced vital capacity. Depending on the sleep metric, anxiety mediated 18–39% of the effect of sleep disturbance on dyspnoea, while muscle weakness mediated 27–41% of this effect.
Interpretation:
Sleep disturbance following hospital admission for COVID-19 is associated with dyspnoea, anxiety, and muscle weakness. Due to the association with multiple symptoms, targeting sleep disturbance might be beneficial in treating the post-COVID-19 condition.
Funding:
UK Research and Innovation, National Institute for Health Research, and Engineering and Physical Sciences Research Council
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