Effect of nuclear transparency from the (p,2p) measurements on 6Li and 12C at 1 GeV

We studied the production of protons to the backward direction in (p,2p) reactions on 6Li and 12C, accompanied by a proton emitted into the forward hemisphere. The momenta of the final two protons were measured in a wide range with the two-arm time-of-flight spectrometer. For each event we reconstructed the mass of the intermediate off-shell particles. We have discovered a strong narrow dip in the mass spectra of intermediate mesons at the mass of the real pion.Comment: 24 pages,11 figure

Immunogenicity assessment of pegfilgrastim in patients with breast cancer

Introduction. Neutropenia, which is an abnormally low concentration of neutrophils in the blood, is one of the common side effects in patients receiving radio-or chemotherapy. Neutropenia usually leads to higher risks of severe bacterial and fungal infections. Such medicines as colony-stimulating factor filgrastim (and its conjugates) are used to prevent and treat neutropenia in oncology patients. Immunogenicity is a potential concern for any biological product, thus, its assessment is one of the most critical necessities during the development and registration of such products. Aim. The main aim of this study was to validate the ELISA method for anti-pegfilgrastim antibodies detection in human serum samples and to apply the validated method to pegfilgrastim drugs immunogenicity assessment. Materials and methods. To assess pegfilgrastim immunogenicity, the commercial ELISA kit «PEGylated Filgrastim (Neulasta®) ADA ELISA» was used for screening, confirmatory and titer assay. Moreover, to confirm the chosen commercial kit suits the study aims it was revalidated. The absorbance values were obtained using plate immunoassay analyzer Stat Fax 3200, plate washing was performed using an automatic two-channel plate washer. Results and discussion. The ELISA method for anti-pegfilgrastim antibodies determination in human serum samples was validated and applied to the analytical part of the comparative, multicenter, blind, randomized study of pegfilgrastim efficacy and safety in patients with breast cancer, receiving myelosuppressive chemotherapy. Human serum samples were first screened for anti-drug antibodies, then «screening positive» samples were analyzed in confirmatory assay with % inhibition calculation for each sample. The «confirmed positive» samples were further characterized in titer assay. Conclusions. The ELISA method for anti-pegfilgrastim antibodies determination in human serum samples was successfully validated and applied for pegfilgrastim drugs immunogenicity assessment. © Medvedev Yu. V., Kolganova M. A., Sas O. A., Komarov T. N., Fisher E. N., Shohin I. E., Ammour Yu. I., 2020

Anxiety: Phenomenology, epidemiology, and risk factors during the novel coronavirus SARS-CoV-2 (COVID-19) pandemic [Тревожность: феноменология, эпидемиология и факторы риска на фоне пандемии, вызванной новым коронавирусом SARS-CoV-2 (COVID-19)]

The novel coronavirus disease 2019 (COVID-19) pandemic has caused significant negative clinical and social impact on peoples' life worldwide. Anxiety, one of the most prevalent mental conditions, tends to spread during periods of social upheaval. The present paper examines the problem of anxiety and reviews epidemiology of anxiety, its risk factors and underlying mechanisms. It discloses associations between anxiety and addictions, lifestyle factors and traumatic childhood experience, and discusses increased anxiety in the context of the novel coronavirus disease (COVID-19) pandemic in Russia. © 2021 Ima-Press Publishing House. All rights reserved

Ресурсы патриотического воспитания молодежи в современной России

Коллективная монография посвящена проблеме патриотизма и патриотического воспитания в современной России. Авторы сначала анализируют культурно-исторические и философские основы патриотизма, а затем – современное состояние патриотического воспитания в России. В работе исследуются организационные, методологические, учебно-методические и правовые аспекты патриотического воспитания, приводятся успешные практики патриотического воспитания. Данная работа предназначена для руководителей образовательных организаций, педагогических и научно-педагогических работников, психологов и всех тех, кто интересуется патриотическим воспитанием и работой с молодежью