THERAPY OF INFLAMMATORY COLONOPATHY IN CHILDREN

The problem of non specific ulcer colitis is one of the most complicated ones in modern gastroenterology, especially in pediatric practice. This is due to the fact that despite successes in studying the pathogenesis of the disease and creation of anti inflammatory medications of the new generation, in the past quarter of the century the incidence of ulcer colitis has increased at 8–14 times. Besides, the incidence of pathological process formation in the infancy has increased at 1,5 times, heavier extraenteric manifestations appeared, development of resistence to traditional therapy is observed more often, early incapacitation of patients, which needs developing new methods of treatment.Key words: non specific ulcer colitis, crohn's disease, therapy, children

THERAPY OF INFLAMMATORY COLONOPATHY IN CHILDREN

The problem of non specific ulcer colitis is one of the most complicated ones in modern gastroenterology, especially in pediatric practice. This is due to the fact that despite successes in studying the pathogenesis of the disease and creation of anti inflammatory medications of the new generation, in the past quarter of the century the incidence of ulcer colitis has increased at 8–14 times. Besides, the incidence of pathological process formation in the infancy has increased at 1,5 times, heavier extraenteric manifestations appeared, development of resistence to traditional therapy is observed more often, early incapacitation of patients, which needs developing new methods of treatment.Key words: non specific ulcer colitis, crohn's disease, therapy, children

ТЕРАПИЯ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ ТОЛСТОЙ КИШКИ У ДЕТЕЙ

The problem of non specific ulcer colitis is one of the most complicated ones in modern gastroenterology, especially in pediatric practice. This is due to the fact that despite successes in studying the pathogenesis of the disease and creation of anti inflammatory medications of the new generation, in the past quarter of the century the incidence of ulcer colitis has increased at 8–14 times. Besides, the incidence of pathological process formation in the infancy has increased at 1,5 times, heavier extraenteric manifestations appeared, development of resistence to traditional therapy is observed more often, early incapacitation of patients, which needs developing new methods of treatment.Key words: non specific ulcer colitis, crohn's disease, therapy, children.Проблема неспецифического язвенного колита является одной из самых сложных в современной гастроэнтерологии, особенно в педиатрической практике. Это обусловлено тем, что, несмотря на успехи в изучении патогенеза болезни и создание противовоспалительных средств нового поколения, за последнюю четверть века заболеваемость язвенным колитом возросла в 8-14 раз. Кроме того, увеличилась в 1,5 раза частота формирования патологического процесса в раннем возрасте, появились более тяжелые внекишечные проявления, чаще наблюдается развитие резистентности к традиционной терапии, ранняя инвалидизация пациентов, что требует разработки новых методов лечения. Ключевые слова: неспецифический язвенный колит, болезнь Крона, детский возраст, медикаментозная терапия.(Педиатрическая фармакология 2008;5(2):38-44

FUNCTIONAL FECAL INCONTINENCE IN CHILDREN (DIFFERENTIAL DIAGNOSTICS AND TREATMENT APPROACHES)

Impairment of the intestinal content continence, a common clinical situation with various pathogenetic mechanisms. Disease proceeds with the child’s maladjustment events. 33 cases of encopresis have been analyzed. This condition has various clinical and instrumental diagnostic criteria depending on the origin which simplifies differential diagnostics. Using a differential diagnostics table helps expedite the process of making a diagnosis and hence start an adequate treatment in a timely manner.Key words: encopresis, differential diagnostics, treatment, children

VARIANTS OF NONSPECIFIC ULCERATIVE COLITIS COURSE IN CHILDREN: PREDICTION AND TREATMENT

Nonspecific ulcerative colitis has different masks, which make it hard for diagnostics. The course of the disease has many variants depending on the kind of therapy, its efficiency. prediction the course of the ulcerative colitis is very important to define the long term treatment management in order to increase the therapy efficiency and improve life quality.Key words: nonspecific ulcerative colitis, prediction the course of the disease, therapy, children

MEDICAL NUTRITION FOR NON SPECIFIC ULCERATIVE COLITIS AND CROHN'S DISEASE IN CHILDREN

Disturbances of nutritive status are typical of patients with non specific ulcerative colitis и crohn's disease with such symptoms as body weight deficiency, disturbance of metabolism associated with the lack of proteins, macro and microelements, energy substrata. Nutrition plays a key role not only in the growth and development processes but also is one of the crucial factors determining the adequacy of the inflammatory response, adaptation compensatory processes. The article considers issues of medicated nutrition under this pathology, including the basic diet, usage of specialized mixes and enteral feeding to correct the protein energy disturbances, and as an independent treatment method.Key words: crohn's disease, non-specific ulcerative colitis, children, diet, enteral feeding, bowel disease

FUNCTIONAL FECAL INCONTINENCE IN CHILDREN (DIFFERENTIAL DIAGNOSTICS AND TREATMENT APPROACHES)

Impairment of the intestinal content continence, a common clinical situation with various pathogenetic mechanisms. Disease proceeds with the child’s maladjustment events. 33 cases of encopresis have been analyzed. This condition has various clinical and instrumental diagnostic criteria depending on the origin which simplifies differential diagnostics. Using a differential diagnostics table helps expedite the process of making a diagnosis and hence start an adequate treatment in a timely manner.Key words: encopresis, differential diagnostics, treatment, children

SORPTION РATHOGENETIC THERAPY OF ENDOGENOUS INTOXICATION OF PEDIATRIC CHRONIC INFLAMMATORY BOWEL DISEASES

Gut endotoxicosis caused by penetration of bacterial and metabolic toxins from chime on the background of increasing permeability of gut wall is of great importance in pathogenesis of chronic inflammatory bowel diseases (nonspecific ulcerative colitis — NUC and Crohn’s disease). It is accompanied by disturbance of regulating homeostasis system with the following disturbances of organs and systems of toxication. Developed endotoxicosis accordingly contributes to maintain and to progress of metabolic and immunological changes. To obtain the precise degree and phase of development of endotoxicosis we estimated quantitative and qualitative changes of metabolic status in accordance with content in erythrocytes, plasma and urine LMMWP (low and medium molecular weight peptides). Taking into concideration the peculiarities of children endotoxicosis with, we suggested patogenetical absorption therapy. Therefore, the therapeutic complex was added enterosorbent ensoral, which absorb eczo and endogenic toxins and, moreover, positive influence for composition of intestinal microflora. Prominent clinical effect was accompanied by positive dynamics of laboratory-instrumental parameters.Key words: endogenous intoxication, inflammatory bowel diseases, nonspecific ulcerative colitis, Crohn’s disease, low and medium molecular weight peptides, enterosorbents, children

VARIANTS OF NONSPECIFIC ULCERATIVE COLITIS COURSE IN CHILDREN: PREDICTION AND TREATMENT

Nonspecific ulcerative colitis has different masks, which make it hard for diagnostics. The course of the disease has many variants depending on the kind of therapy, its efficiency. prediction the course of the ulcerative colitis is very important to define the long term treatment management in order to increase the therapy efficiency and improve life quality.Key words: nonspecific ulcerative colitis, prediction the course of the disease, therapy, children