Unambiguous quantization from the maximum classical correspondence that is self-consistent: the slightly stronger canonical commutation rule Dirac missed

Dirac's identification of the quantum analog of the Poisson bracket with the commutator is reviewed, as is the threat of self-inconsistent overdetermination of the quantization of classical dynamical variables which drove him to restrict the assumption of correspondence between quantum and classical Poisson brackets to embrace only the Cartesian components of the phase space vector. Dirac's canonical commutation rule fails to determine the order of noncommuting factors within quantized classical dynamical variables, but does imply the quantum/classical correspondence of Poisson brackets between any linear function of phase space and the sum of an arbitrary function of only configuration space with one of only momentum space. Since every linear function of phase space is itself such a sum, it is worth checking whether the assumption of quantum/classical correspondence of Poisson brackets for all such sums is still self-consistent. Not only is that so, but this slightly stronger canonical commutation rule also unambiguously determines the order of noncommuting factors within quantized dynamical variables in accord with the 1925 Born-Jordan quantization surmise, thus replicating the results of the Hamiltonian path integral, a fact first realized by E. H. Kerner. Born-Jordan quantization validates the generalized Ehrenfest theorem, but has no inverse, which disallows the disturbing features of the poorly physically motivated invertible Weyl quantization, i.e., its unique deterministic classical "shadow world" which can manifest negative densities in phase space.Comment: 12 pages, Final publication in Foundations of Physics; available online at http://www.springerlink.com/content/k827666834140322

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men