RENIN ANGIOTENSIN SYSTEM GENE POLYMORPHISMS IN CHILDREN WITH NEPHROTIC SYNDROM

To investigate the role of the reninangiotensin system genes polymorphisms in develop and progression of nephrotic syndrom (NS) in children we determined the genotypes of angiotensin converting enzyme (ACE), angiotensinogen (AGT) and angiotensin ii receptor (ATII-R) of 1 type in 80 russian children with ns including and 15 children with chronic renal failure (CRF). Genotype frequencies did not differ between patients with ns and controls (n = 165). The distribution of ace, AGT and ATII-R 1 type genotypes was similar among ns sub groups, such as focal segmental glomerulosclerosis (FSGS) (n = 18), steroid-sensitive nephrotic syndrome (n = 32), nephrotic syndrome with hypertension and hemoturia (n = 22) and with control group. When ns subjects with CRF (n = 15) were compared with control, the prevalence of ace DD genotype was significantly higher (47% VS 21%; χ2 = 4,44; p < 0,05). Our results indicate that the DD genotype ace may be a factor of risk for the dеvеlopment of progressive renal impairment in the children with nephrotic syndrome. The analysis of treatment's effect with inhibitor of ace in groups patients with steroid resistant NS (SRNS) demonstrated decreasing of renoprotective effect of this drugs in patients with id and dd genotypes com? Pared with ii genotype: the degree of blood pressure, proteinuria and the rate of glomerular filtration decrease was significantly lower (55,46 ± 9,25 VS 92,74 ± 25; р < 0,05) in these patients.Key words: nephrotic syndrom, chronic renal failure, polymorphism of genes, renin-angiotensin system

RENIN ANGIOTENSIN SYSTEM GENE POLYMORPHISMS IN CHILDREN WITH NEPHROTIC SYNDROM

To investigate the role of the reninangiotensin system genes polymorphisms in develop and progression of nephrotic syndrom (NS) in children we determined the genotypes of angiotensin converting enzyme (ACE), angiotensinogen (AGT) and angiotensin ii receptor (ATII-R) of 1 type in 80 russian children with ns including and 15 children with chronic renal failure (CRF). Genotype frequencies did not differ between patients with ns and controls (n = 165). The distribution of ace, AGT and ATII-R 1 type genotypes was similar among ns sub groups, such as focal segmental glomerulosclerosis (FSGS) (n = 18), steroid-sensitive nephrotic syndrome (n = 32), nephrotic syndrome with hypertension and hemoturia (n = 22) and with control group. When ns subjects with CRF (n = 15) were compared with control, the prevalence of ace DD genotype was significantly higher (47% VS 21%; χ2 = 4,44; p < 0,05). Our results indicate that the DD genotype ace may be a factor of risk for the dеvеlopment of progressive renal impairment in the children with nephrotic syndrome. The analysis of treatment's effect with inhibitor of ace in groups patients with steroid resistant NS (SRNS) demonstrated decreasing of renoprotective effect of this drugs in patients with id and dd genotypes com? Pared with ii genotype: the degree of blood pressure, proteinuria and the rate of glomerular filtration decrease was significantly lower (55,46 ± 9,25 VS 92,74 ± 25; р < 0,05) in these patients.Key words: nephrotic syndrom, chronic renal failure, polymorphism of genes, renin-angiotensin system

ПОЛИМОРФИЗМ ГЕНОВ РЕНИН-АНГИОТЕНЗИНОВОЙ СИСТЕМЫ ПРИ НЕФРОТИЧЕСКОМ СИНДРОМЕ У ДЕТЕЙ

To investigate the role of the reninangiotensin system genes polymorphisms in develop and progression of nephrotic syndrom (NS) in children we determined the genotypes of angiotensin converting enzyme (ACE), angiotensinogen (AGT) and angiotensin ii receptor (ATII-R) of 1 type in 80 russian children with ns including and 15 children with chronic renal failure (CRF). Genotype frequencies did not differ between patients with ns and controls (n = 165). The distribution of ace, AGT and ATII-R 1 type genotypes was similar among ns sub groups, such as focal segmental glomerulosclerosis (FSGS) (n = 18), steroid-sensitive nephrotic syndrome (n = 32), nephrotic syndrome with hypertension and hemoturia (n = 22) and with control group. When ns subjects with CRF (n = 15) were compared with control, the prevalence of ace DD genotype was significantly higher (47% VS 21%; χ2 = 4,44; p < 0,05). Our results indicate that the DD genotype ace may be a factor of risk for the dеvеlopment of progressive renal impairment in the children with nephrotic syndrome. The analysis of treatment's effect with inhibitor of ace in groups patients with steroid resistant NS (SRNS) demonstrated decreasing of renoprotective effect of this drugs in patients with id and dd genotypes com? Pared with ii genotype: the degree of blood pressure, proteinuria and the rate of glomerular filtration decrease was significantly lower (55,46 ± 9,25 VS 92,74 ± 25; р < 0,05) in these patients.Key words: nephrotic syndrom, chronic renal failure, polymorphism of genes, renin-angiotensin system.Для исследования роли полиморфизма генов ангиотензинпревращающего фермента (АПФ), ангиотензиногена (АТГ) и рецептора ангиотензина II 1-го типа (АТII-R) в развитии и прогрессировании нефротического синдрома (НС) у детей, мы определили их генотипы у 80 российских детей с НС, включая 15 детей с хронической почечной недостаточностью (ХПН). Частота генотипов достоверно не отличалась между нефротическими больными и контролем (n = 165). Распределение генотипов АПФ, АТГ и АТII-R 1-го типа было схожим среди больных с фокально-сегментарным гломерулосклерозом (n = 18), стероидчувствительным нефротическим синдромом (n = 32), нефротическим синдромом с артериальной гипертензией и гематурией (n = 22) и контролем. Преобладание DD генотипа АПФ было достоверно в группе больных с ХПН (47% против 21%; χ2 = 4,44; p < 0,05). Таким образом, DD генотип может быть фактором риска прогрессирования НС до стадии ХПН. Анализ эффективности терапии ингибиторами АПФ в группах больных стероидрезистентным НС (СРНС) выявил снижение их нефропротективного эффекта у больных с ID и DD генотипами по сравнению с I гомозиготами при схожем снижении уровня артериального давления и протеинурии, Скорость клубочковой фильтрации у этих больных была достоверно ниже (55,46 ±?9,25 по сравнению с 92,74 ± 25; р < 0,05). Ключевые слова: нефротический синдром, хроническая почечная недостаточность, полиморфизм генов, ренин-ангиотензиновая система.(Педиатрическая фармакология. – 2006; 3(4): 10-16