Associations between change in blood pressure and functional outcome, early events and death: Results from the Efficacy of Nitric Oxide in Stroke trial

Objectives:High blood pressure (BP) is associated with a poor outcome after acute stroke. Early reduction in BP may be associated with fewer early adverse events and deaths, and improved functional outcome.Methods:Analyses used data from the Efficacy of Nitric Oxide in Stroke trial, a multicentre randomized single-masked and outcome-masked trial of glyceryl trinitrate vs. no glyceryl trinitrate in 4011 patients recruited within 48h of an ischaemic or haemorrhagic stroke and with raised SBP (140-220mmHg). Change in SBP from baseline to day 1 was categorized as: more than 15% decrease, 15-5% decrease, 5% decrease to 5% increase (no change-reference) and more than 5% increase. The primary outcome was functional outcome (modified Rankin scale) score at 90 days.Results:Across all patients, both moderate (5-15%) and large (>15%) decreases in SBP were associated with beneficial shifts in the modified Rankin scale relative to patients with no change in BP: Adjusted common odds ratio (OR) 0.81 [95% confidence interval (CI) 0.70-0.90] and OR 0.84 (95% CI 0.71-1.00), respectively. A moderate decrease in SBP was also associated with a lower risk of early adverse events, adjusted OR 0.69 (95% CI 0.52-0.90).Conclusion:Modest decreases in SBP in acute stroke appear to be associated with fewer early events and better long-Term functional outcome. © 2019 Wolters Kluwer Health, Inc. All rights reserved

Project overview of OPTIMOS-EVE: The fibre-fed multi-object spectrograph for the E-ELT

OPTIMOS-EVE (OPTical Infrared Multi Object Spectrograph - Extreme Visual Explorer) is the fibre fed multi object spectrograph proposed for the European Extremely Large Telescope (E-ELT), planned to be operational in 2018 at Cerro Armazones (Chile). It is designed to provide a spectral resolution of 6000, 18000 or 30000, at wavelengths from 370 nm to 1.7 μm, combined with a high multiplex (>200) and a large spectral coverage. Additionally medium and large IFUs are available. The system consists of three main modules: a fibre positioning system, fibres and a spectrograph. The recently finished OPTIMOS-EVE Phase-A study, carried out within the framework of the ESO E-ELT instrumentation studies, has been performed by an international consortium consisting of institutes from France, Netherlands, United Kingdom and Italy. All three main science themes of the E-ELT are covered by this instrument: Planets and Stars; Stars and Galaxies; Galaxies and Cosmology. This paper gives an overview of the OPTIMOS-EVE project, describing the science cases, top level requirements, the overall technical concept and the project management approach. It includes a description of the consortium, highlights of the science drivers and resulting science requirements, an overview of the instrument design and telescope interfaces, the operational concept, expected performance, work breakdown and management structure for the construction of the instrument, cost and schedule. © 2010 Copyright SPIE - The International Society for Optical Engineering

Project overview of OPTIMOS-EVE: the fibre-fed multi-object spectrograph for the E-ELT

OPTIMOS-EVE (OPTical Infrared Multi Object Spectrograph - Extreme Visual Explorer) is the fibre fed multi object spectrograph proposed for the European Extremely Large Telescope (E-ELT), planned to be operational in 2018 at Cerro Armazones (Chile). It is designed to provide a spectral resolution of 6000, 18000 or 30000, at wavelengths from 370 nm to 1.7 μm, combined with a high multiplex (>200) and a large spectral coverage. Additionally medium and large IFUs are available. The system consists of three main modules: a fibre positioning system, fibres and a spectrograph. The recently finished OPTIMOS-EVE Phase-A study, carried out within the framework of the ESO E-ELT instrumentation studies, has been performed by an international consortium consisting of institutes from France, Netherlands, United Kingdom and Italy. All three main science themes of the E-ELT are covered by this instrument: Planets and Stars; Stars and Galaxies; Galaxies and Cosmology. This paper gives an overview of the OPTIMOS-EVE project, describing the science cases, top level requirements, the overall technical concept and the project management approach. It includes a description of the consortium, highlights of the science drivers and resulting science requirements, an overview of the instrument design and telescope interfaces, the operational concept, expected performance, work breakdown and management structure for the construction of the instrument, cost and schedule