662 research outputs found
Equivalent thermo-mechanical parameters for perfect crystals
Thermo-elastic behavior of perfect single crystal is considered. The crystal
is represented as a set of interacting particles (atoms). The approach for
determination of equivalent continuum values for the discrete system is
proposed. Averaging of equations of particles' motion and long wave
approximation are used in order to make link between the discrete system and
equivalent continuum. Basic balance equations for equivalent continuum are
derived from microscopic equations. Macroscopic values such as Piola and Cauchy
stress tensors and heat flux are represented via microscopic parameters.
Connection between the heat flux and temperature is discussed. Equation of
state in Mie-Gruneisen form connecting Cauchy stress tensor with deformation
gradient and thermal energy is obtained from microscopic considerations.Comment: To be published in proceedings of IUTAM Simposium on "Vibration
Analysis of Structures with Uncertainties", 2009; 14 pages
Addition Spectra of Quantum Dots in Strong Magnetic Fields
We consider the magnetic field dependence of the chemical potential for
parabolically confined quantum dots in a strong magnetic field. Approximate
expressions based on the notion that the size of a dot is determined by a
competition between confinement and interaction energies are shown to be
consistent with exact diagonalization studies for small quantum dots. Fine
structure is present in the magnetic field dependence which cannot be explained
without a full many-body description and is associated with ground-state level
crossings as a function of confinement strength or Zeeman interaction strength.
Some of this fine structure is associated with precursors of the bulk
incompressible states responsible for the fractional quantum Hall effect.Comment: 11 pages, 3 figures (available from [email protected]). Revtex
3.0. (IUCM93-010
Effects of exposure to Diazinon on the lung and small intestine of Guinea pig, histological and some histochemical changes
ThermoElectric Transport Properties of a Chain of Quantum Dots with Self-Consistent Reservoirs
We introduce a model for charge and heat transport based on the
Landauer-Buttiker scattering approach. The system consists of a chain of
quantum dots, each of them being coupled to a particle reservoir. Additionally,
the left and right ends of the chain are coupled to two particle reservoirs.
All these reservoirs are independent and can be described by any of the
standard physical distributions: Maxwell-Boltzmann, Fermi-Dirac and
Bose-Einstein. In the linear response regime, and under some assumptions, we
first describe the general transport properties of the system. Then we impose
the self-consistency condition, i.e. we fix the boundary values (T_L,\mu_L) and
(T_R,mu_R), and adjust the parameters (T_i,mu_i), for i = 1,...,N, so that the
net average electric and heat currents into all the intermediate reservoirs
vanish. This condition leads to expressions for the temperature and chemical
potential profiles along the system, which turn out to be independent of the
distribution describing the reservoirs. We also determine the average electric
and heat currents flowing through the system and present some numerical
results, using random matrix theory, showing that these currents are typically
governed by Ohm and Fourier laws.Comment: Minor changes (45 pages
TP53 germline mutation testing in 180 families suspected of Li-Fraumeni syndrome: mutation detection rate and relative frequency of cancers in different familial phenotypes
Active Galactic Nuclei at the Crossroads of Astrophysics
Over the last five decades, AGN studies have produced a number of spectacular
examples of synergies and multifaceted approaches in astrophysics. The field of
AGN research now spans the entire spectral range and covers more than twelve
orders of magnitude in the spatial and temporal domains. The next generation of
astrophysical facilities will open up new possibilities for AGN studies,
especially in the areas of high-resolution and high-fidelity imaging and
spectroscopy of nuclear regions in the X-ray, optical, and radio bands. These
studies will address in detail a number of critical issues in AGN research such
as processes in the immediate vicinity of supermassive black holes, physical
conditions of broad-line and narrow-line regions, formation and evolution of
accretion disks and relativistic outflows, and the connection between nuclear
activity and galaxy evolution.Comment: 16 pages, 5 figures; review contribution; "Exploring the Cosmic
Frontier: Astrophysical Instruments for the 21st Century", ESO Astrophysical
Symposia Serie
Whole Gene Capture Analysis of 15 CRC Susceptibility Genes in Suspected Lynch Syndrome Patients
Background and Aims Lynch Syndrome (LS) is caused by pathogenic germline variants in one of the mismatch repair (MMR) genes. However, up to 60% of MMR-deficient colorectal cancer cases are categorized as suspected Lynch Syndrome (sLS) because no pathogenic MMR germline variant can be identified, which leads to difficulties in clinical management. We therefore analyzed the genomic regions of 15 CRC susceptibility genes in leukocyte DNA of 34 unrelated sLS patients and 11 patients with MLH1 hypermethylated tumors with a clear family history. Methods Using targeted next-generation sequencing, we analyzed the entire non-repetitive genomic sequence, including intronic and regulatory sequences, of 15 CRC susceptibility genes. In addition, tumor DNA from 28 sLS patients was analyzed for somatic MMR variants. Results Of 1979 germline variants found in the leukocyte DNA of 34 sLS patients, one was a pathogenic variant (MLH1 c.1667+1delG). Leukocyte DNA of 11 patients with MLH1 hypermethylated tumors was negative for pathogenic germline variants in the tested CRC susceptibility genes and for germline MLH1 hypermethylation. Somatic DNA analysis of 28 sLS tumors identified eight (29%) cases with two pathogenic somatic variants, one with a VUS predicted to pathogenic and LOH, and nine cases (32%) with one pathogenic somatic variant (n = 8) or one VUS predicted to be pathogenic (n = 1). Conclusions This is the first study in sLS patients to include the entire genomic sequence of CRC susceptibility genes. An underlying somatic or germline MMR gene defect was identified in ten of 34 sLS patients (29%). In the remaining sLS patients, the underlying genetic defect explaining the MMRdeficiency in their tumors might be found outside the genomic regions harboring the MMR and other known CRC susceptibility genes
Development of a High Intensity Neutron Source at the European Spallation Source: The HighNESS project
The European Spallation Source (ESS), presently under construction in Lund,
Sweden, is a multidisciplinary international laboratory that will operate the
world's most powerful pulsed neutron source. Supported by a 3M Euro Research
and Innovation Action within the EU Horizon 2020 program, a design study
(HighNESS) is now underway to develop a second neutron source below the
spallation target. Compared to the first source, located above the spallation
target and designed for high cold and thermal brightness, the new source will
provide higher intensity, and a shift to longer wavelengths in the spectral
regions of cold (2 /- 20 {\AA}), very cold (VCN, 10 /- 120 {\AA}), and ultra
cold (UCN, > 500 {\AA}) neutrons. The core of the second source will consist of
a large liquid deuterium moderator to deliver a high flux of cold neutrons and
to serve secondary VCN and UCN sources, for which different options are under
study. The features of these new sources will boost several areas of condensed
matter research and will provide unique opportunities in fundamental physics.
Part of the HighNESS project is also dedicated to the development of future
instruments that will make use of the new source and will complement the
initial suite of instruments in construction at ESS. The HighNESS project
started in October 2020. In this paper, the ongoing developments and the
results obtained in the first year are described.Comment: 10 pages, 10 figures, 14th International Topical Meeting on Nuclear
Applications of Accelerators, November 30 to December 4, 2021, Washington, D
Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility
Background: In approximately 10% of all gastric cancer (GC) cases, a heritable cause is suspected. A subset of these cases have a causative germline CDH1 mutation; however, in most cases the cause remains unknown. Our objective was to assess to what extent these remaining cases may be explained by germline mutations in the novel candidate GC predisposing genes CTNNA1, MAP3K6 or MYD88. Methods: We sequenced a large cohort of unexplained young and/or familial patients with GC (n=286) without a CDH1germline mutation for germline variants affecting CTNNA1, MAP3K6 and MYD88 using a targeted next-generation sequencing approach based on single-molecule molecular inversion probes. Results: Predicted deleterious germline variants were not encountered in MYD88, but recurrently observed in CTNNA1 (n=2) and MAP3K6 (n=3) in our cohort of patients with GC. In contrast to deleterious variants in CTNNA1, deleterious variants in MAP3K6 also occur frequently in the general population. Conclusions: Based on our results MAP3K6 should no longer be considered a GC predisposition gene, whereas deleterious CTNNA1 variants are confirmed as an infrequent cause of GC susceptibility. Biallelic MYD88 germline mutations are at most a very rare cause of GC susceptibility as no additional cases were identified
Correlations between the peak flux density and the position angle of inner-jet in three blazars
We aim to investigate the relation between the long-term flux density and the
position angle (PA) evolution of inner-jet in blazars. We have carried out the
elliptic Gaussian model-fit to the `core' of 50 blazars from 15 GHz VLBA data,
and analyzed the variability properties of three blazars from the model-fit
results. Diverse correlations between the long-term peak flux density and the
PA evolution of the major axis of the `core' have been found in 20% of
the 50 sources. Of them, three typical blazars have been analyzed, which also
show quasi-periodic flux variations of a few years (T). The correlation between
the peak flux density and the PA of inner-jet is positive for S5~0716+714, and
negative for S4~1807+698. The two sources cannot be explained with the
ballistic jet models, the non-ballistic models have been analyzed to explain
the two sub-luminal blazars. A correlation between the peak flux density and
the PA (with a T/4 time lag) of inner-jet is found in [HB89]~1823+568, this
correlation can be explained with a ballistic precession jet model. All the
explanations are based mainly on the geometric beaming effect; physical flux
density variations from the jet base would be considered for more complicated
situations in future, which could account for the no or less significance of
the correlation between the peak flux density and the PA of inner-jet in the
majority blazars of our sample.Comment: 6 pages, 7 figures, accepted for publication in Astrophysics and
Space Scienc
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