Результаты модернизации подходов ведения пуэрперия при преждевременных родах

The information on alternative tactics in puerperium with the using of modern perinatal technologies (MPT) accumulated only for urgent delivery. Nevertheless, the experience of local researchers is confirming the effectiveness of the reorganization tactics in postpartum period and reducing maternal and neonatal ID (inflammatory disease) on the basis of priority, it would seem natural to human nature, is very optimistic. In this regard, our objectives is: to improve the outcomes of preterm delivery through the introduction of modern perinatal technologies. The contingent of the study were four groups formed according to the gestational age at the time of preterm delivery and adherence to policies MPT in the postpartum period. Couples are selected on the basis of — mother — newborn (101 pair). Criteria for inclusion in the group: singleton pregnancy, preterm delivery in 28—36 weeks of pregnancy. Implementation of MPT provided the reduction in reporting cases of mothers in the ID one and a half times ( p < 0,05), neonates (with hospital infection) — nearly seven times ( p < 0,05). We believe it possible to reduce episodes of neonatal ID associated with a positive effect of continuous skin contact of mother with a newborn. The basis for this conclusion is the meta-analysis demonstrating a significant reduction in mortality in preterm infants weighing less than 2000 g, and their severe morbidity, especially from infections.Сведения об альтернативной тактике ведения пуэрперия за счет внедрения современных перинатальных технологий накоплены только в отношении срочных родов. Тем не менее опыт отечественных исследователей в подтверждении эффективности реорганизации тактики ведения послеродового периода и снижении ГСИ матерей и новорожденных на основании приоритета, казалось бы, естественных природе человека мер крайне оптимистичен. В связи с этим нами поставлена цель: улучшить исходы преждевременных родов путем внедрения современных перинатальных технологий. Контингент исследования составили четыре группы, сформированные в зависимости от срока гестации на момент преждевременных родов и следования стратегии СПТ в послеродовом периоде. Пары подобраны по принципу — родильница — новорожденный (101 пара). Критерии включения в группы: одноплодная беременность, преждевременные роды в 28—36 недель беременности. Внедрение СПТ обеспечило снижение регистрации случаев ГСИ матерей в полтора раза ( p < 0,05), новорожденных (вариант госпитального инфицирования) — практически в семь раз ( p < 0,05). Полагаем возможным сокращение эпизодов ГСИ новорожденных связать с позитивным влиянием непрерывного кожного контакта матери с младенцем. Основанием для подобного вывода являются данные мета-анализа, демонстрирующего существенное снижение смертности недоношенных новорожденных весом менее 2000 г, их тяжелой заболеваемости, особенно, от инфекций

The Role of Attitude to the Disease in Cardiac Patients Undergoing Vital Threat in the Formation of the Prediction of their Mental Adaptation to Post-hospital Period

The study was supported by the grant of the President of the Russian Federation MK-2076.2012.6. In the current study, the authors evaluated the role of relationship to disease in cardiac patients undergoing vital threat in the formation of the prediction of their mental adaptation in the distant post-hospital period. Longitudinal study (in-hospital and one year after discharge) included two groups: patients with urgent cardiac status (N=47, 36 men, 11 women, age 34 to 66 years) and patients with atrial arrhythmias, passing minimally invasive surgery (N=41, 22 men, 19 women, age 41 to 69 years). In-hospital stage used interviews and tests, questionnaires, and post-hospital stage was conducted using a telephone interview. We found that patients with a history of life-threatening cardiac condition, are less concerned about the disease than patients expecting to be relatively safe after minimally invasive surgery. In the forecast of the emotional status of patients, the severity of anxiety and disturbance of interpersonal relationships in the hospital period play an important role. Predictor of adherence to medical recommendations for men is a high disease concern, and in women – greater emotional stability

Effect of ADRB gene polymorphism on the efficacy and safety of tocolytic therapy with β2-adrenergic agonists in preterm birth

G.F. Proklova1, R.A. Chilova1, E.A. Sokova2, R.E. Kazakov2, E.V. Zhukova1, K.O. Akopov3, N.S. Trifonova1 1I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation 2Scientific Centre for Expert Evaluation of Medicinal Products, Moscow, Russian Federation 3S.S. Yudin City Clinical Hospital, Moscow, Russian Federation This paper reviews the effects of ADRB2 gene polymorphism on the efficacy of tocolytic therapy in preterm birth. Statistically, prematurity accounts for 70% to 75% of neonatal and infant mortality while stillbirths are 13 times more common in preterm birth compared to full-term birth. Despite modern diagnostic and treatment options to manage threatened preterm labor, its rate does not reduce. Meanwhile, pregnancy prolongation even by 48 hours is often enough to prevent newborn respiratory distress syndrome thereby improving perinatal outcomes, saving many lives of preterm babies, and preventing disability. That is why it is so important to initiate early maximally efficient and safe for a fetus tocolytic therapy aimed at prolonging the pregnancy. It was demonstrated that individual genetic variations determining intranatal phenotype exist. However, the associations between genetic characteristics and the rate of labor activity were currently demonstrated only for single genes.&nbsp; This is particularly true for a gene encoding β2-adrenergic receptors whose stimulation in the uterus and cervix by endogenous and exogenous agonists relaxes smooth muscles. Keywords: preterm birth, perinatal outcome, tocolytic therapy, ADRB2 gene polymorphism, β2-adrenergic receptors, single nucleotide polymorphism. For citation: Proklova G.F., Chilova R.A., Sokova E.A. et al. Effect of ADRB gene polymorphism on the efficacy and safety of tocolytic therapy with β2-adrenergic agonists in preterm birth. Russian Journal of Woman and Child Health. 2020;3(3):194–197. DOI: 10.32364/2618-8430-2020-3-3-194-197. <br

Cyclobutadiene Arene Complexes of Rhodium and Iridium

Reactions of [(C2H4)2RhCl]2 or [(coe)2RhCl]2 (coe = cyclooctene) with AgPF6 and arenes, followed by addition of 3-hexyne, give the cyclobutadiene complexes [(C4Et4)Rh(arene)]+ in 40-65% yield (arene = tert-butylbenzene, p-xylene, mesitylene, 4-mesitylbutanoic acid). In the absence of arenes, the hexaethylbenzene complex [(C4Et4)Rh(C6Et6)]+ is formed in 70% yield as a result of cyclotrimerization of 3-hexyne in the coordination sphere of rhodium. Similar reaction of [(coe)2IrCl]2 with AgPF6 and 3-hexyne leads to [(C4Et4)Ir(C6Et6)]+, which is apparently the first reported cyclobutadiene iridium complex. DFT calculations suggest that formation of the model cyclobutadiene complex [(C4Me4)Rh(C6H6)]+ from bis(alkyne) intermediate [(C2Me2)2Rh(C6H6)]+ can proceed via a metallacycle transition state with a low energy barrier of 14.5 kcal mol-1. © 2016 American Chemical Society

Cyclobutadiene Arene Complexes of Rhodium and Iridium

Reactions of [(C2H4)2RhCl]2 or [(coe)2RhCl]2 (coe = cyclooctene) with AgPF6 and arenes, followed by addition of 3-hexyne, give the cyclobutadiene complexes [(C4Et4)Rh(arene)]+ in 40-65% yield (arene = tert-butylbenzene, p-xylene, mesitylene, 4-mesitylbutanoic acid). In the absence of arenes, the hexaethylbenzene complex [(C4Et4)Rh(C6Et6)]+ is formed in 70% yield as a result of cyclotrimerization of 3-hexyne in the coordination sphere of rhodium. Similar reaction of [(coe)2IrCl]2 with AgPF6 and 3-hexyne leads to [(C4Et4)Ir(C6Et6)]+, which is apparently the first reported cyclobutadiene iridium complex. DFT calculations suggest that formation of the model cyclobutadiene complex [(C4Me4)Rh(C6H6)]+ from bis(alkyne) intermediate [(C2Me2)2Rh(C6H6)]+ can proceed via a metallacycle transition state with a low energy barrier of 14.5 kcal mol-1. © 2016 American Chemical Society

Spherical particles derived from TMV virions enhance the protective properties of the rabies vaccine

In this study the ability of spherical particles (SPs) obtained from the tobacco mosaic virus (TMV) virions to enhance the immunogenic potential of the vaccine was evaluated. TMV SPs were shown to increase the protective properties of the widely used effective Russian adjuvant-free rabies vaccine, composed of killed rabies virions. The results of the NIH potency test showed enhancement of protectivity, that is comparable with the effect of the incomplete Freund׳s adjuvant on the same vaccine. Keywords: Rabies vaccine, Plant virus, Spherical particles, Adjuvan

Data in support of toxicity studies of structurally modified plant virus to safety assessment

This data article is related to the research article entitled “Assessment of structurally modified plant virus as a novel adjuvant in toxicity studies” (Nikitin et al., 2018), devoted to the safety study of structurally modified plant virus - spherical particles (SPs). SPs are generated by thermally denatured tobacco mosaic virus (TMV) coat protein and act as effective adjuvant for development of new vaccine candidates. This article reports the additional results on the toxicity studies of TMV SPs. The weight coefficients of laboratory animals internal organs complements the data of the subchronic toxicity studies. Also plaque-forming cell assay, delayed-type hypersensitivity test and peritoneal macrophage assay as a part of immunotoxicity studies of TMV SPs are presented. Keywords: Plant virus, Tobacco mosaic virus, Spherical particles, Toxicit