9 research outputs found
Simulated Brain Tumor Growth Dynamics Using a Three-Dimensional Cellular Automaton
- Author
- A.R. KANSAL
- ALVORD
- ANNEGERS
- AXELROD
- BAGLEY
- BAUER
- BLACK
- BLANKENBERG
- BRUNTON
- BURGER
- BURGER
- BURGER
- BURGESS
- BYRNE
- CARLSSON
- CARLSSON
- CHAPLAIN
- COFFEY
- COOPER
- CRUYWAGEN
- DAM
- DURAND
- DÜCHTING
- E.A. CHIOCCA
- EARNEST
- FOLKMAN
- FOULDS
- FREYER
- FREYER
- FREYER
- FREYER
- FREYER
- G.R. HARSH
- GATENBY
- GIANGASPERO
- GIESE
- GREENSPAN
- HAJI-KARIM
- HAROSKE
- HELMLINGER
- HOSHINO
- HOSHINO
- I0TURNER
- KAUFFMAN
- KELLY
- KISS
- KRAUS
- LANDRY
- LANG
- MARUSIC
- MUELLER-KLIESER
- MUELLER-KLIESER
- NAZZARO
- NORTON
- OKABE
- PAULUS
- PERTUISET
- PERUMPANANI
- PIERALLINI
- PRESTON
- QI
- ROTIN
- RUBIN
- S. TORQUATO
- SCHIFFER
- SCHWAB
- SELKER
- SHERRATT
- SILBERGELD
- SMOLLE
- SMOLLE
- STEEL
- SUH
- SUTHERLAND
- T.S. DEISBOECK
- TRACQUI
- TRACQUI
- VAIDYA
- WALISZEWSKI
- WARD
- WASSERMAN
- WERNER
- WHITTLE
- WOLFRAM
- WOODWARD
- YAMASHITA
- YOSHII
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Exploring the link between innate immune activation and thymic function by measuring sCD14 and TRECs in HIV patients living in Belgium
- Author
- A De Voeght
- A Leon
- A Nazli
- A Schuetz
- Adrien De Voeght
- AP Reiner
- B Jacque
- C Oesterreicher
- C Schütt
- Chantal Renard
- CT Longenecker
- D C Douek
- D Sauce
- D.B Palmer
- DC Douek
- Dolores Vaira
- E Castermans
- E Lien
- E.A. Freyer
- G Morrhaye
- Gilles Darcis
- GL Su
- H. Loppnow
- Henri Martens
- Hick Ryan W.
- JJ Durieux
- JM Brenchley
- JM Brenchley
- Johan K. Sandberg
- JS Sutherland
- Julie Simonet
- JV Giorgi
- Kruskal
- LC Ndhlovu
- M Abad-Fernandez
- M Zeng
- M.F Chevalier
- Mathieu Debruche
- Michel Moutschen
- ML Dion
- NG Sandler
- NR Klatt
- P. A. Thompson
- PI Lee
- R. L. Kitchens
- RC Kalayjian
- RD Berg
- S Bas
- S Ferrando-Martinez
- S Takeshita
- SD Wang
- TW Kuijpers
- V Bazil
- V Geenen
- Vincent Geenen
- WE Owens
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2017
- Field of study
Microbial translocation is now viewed as a central event in the pathogenesis of chronic inflammation during HIV infection. Thymic function failure is another crucial factor involved in HIV disease progression. The goal of this study was to explore the hypothesis of potential links between microbial translocation and thymic function in HIV-1 patients living in Belgium. The extent of microbial translocation was assessed through the measurement of soluble CD14 (sCD14). T-cell receptor excision circles (sjTRECs and dβTRECs) were used as a measure of thymic function. Data were collected from 75 HIV-infected patients. Simple and complex linear regressions were done to analyze the link between these two processes. We found a statistically relevant negative correlation between thymopoiesis (sjTREC) and sCD14 level (p = 0.004). These results suggest a link between thymic function failure, microbial translocation and innate immune activation
The trilobite generaEocryphops andPlagiolaria (Phacopidae)
- Author
- A.T. Thomas
- C J.B. Amyot
- C. Crônier
- C.H.T. Townsend
- Cheng-yuan Wang
- David J. Holloway
- E.A. Balashova
- E.A. Balashova
- E.T. Cresson
- F. Herrmann
- F. Lütke
- F.A. Roemer
- G. Freyer
- G.K.B. Alberti
- G.K.B. Alberti
- G.K.B. Alberti
- G.K.B. Alberti
- G.K.B. Alberti
- G.K.B. Alberti
- G.K.B. Alberti
- G.K.B. Alberti
- G.K.B. Alberti
- G.K.B. Alberti
- G.K.B. Alberti
- H. Alberti
- H. Alberti
- H. B. Whittington
- H. Flick
- H.K. Erben
- I. Chlupáč
- I. Chlupáč
- I. Chlupáč
- Jia-Ling Wang
- K. Walther
- K.S.W. Campbell
- K.S.W. Campbell
- L Ramsköld
- R. Feist
- R. Feist
- R.A. Fortey
- Reinhard Richter
- Reinhard Richter
- Rudolf Richter
- Rudolf Richter
- Rudolf Richter
- Rudolf Richter
- T. Kobayashi
- T. Kobayashi
- T. Kobayashi
- W. Franke
- W. Kegel
- W. Kegel
- W. Struve
- Wen-tang Chang (Zhang)
- Yon-gen Yi
- Z.A. Maksimova
- ZA Maksimova
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Structure and characterization of the gene encoding .ALPHA. subunit of soybean .BETA.-conglycinin.
- Author
- Bray E.A. and Beachy, R.N.
- Brown D., Ellis, T.H.N. and Gatehouse, J.A.
- Doyle J.J., Schuler, M.A., Godette, W.D., Zenger, V. and Beachy, R.N.
- Fujisawa T. and Beachy, R.N.
- Goldberg R.B., Hoschek, G., Ditta, G.S. and Breidenbach, R.W.
- Higgins T.J.V., Newbigin, E.J.,Spencer, D., Llewellyn D.J. and Craig, S.
- Holowach L.P., Madison, J.T. and Thompson, J.F.
- Kitamura K. and Kaizuma, N.
- Ladin B.F., Doyle, J.J. and Beachy, R.N.
- Lelievre J.M., Dickinson, C.D., Dickinson, L.A. and Nielsen, N.C.
- Lessard P.A., Allen, R.D., Bernier, F., Crispino, J.D., Fujiwara, T., Beachy, R.N.
- Meinke D.W., Chen, J. and Beachy, R.N.
- Naito S., Dube, P.H. and Beachy, R.N.
- Schuler M.A., Ladin, B.F., Pollaco, J.C., Freyer, G. and Beachy, R.N.
- Sebastiani F.L., Farrell, L.B., Schuler, M.A. and Beachy, R.N.
- Takahashi K., Banba, H., Kikuchi, A., Ito, M. and Nakamura, S.
- Takei Y., Yamauchi, D. and Minamikawa, T.
- TERUI Y
- Thanh V.H. and Shibasaki, K.
- Thanh V.H. and Shibasaki, K.
- Tierney M.L., Bray, E.A., Allen, R.D., Ma, Y., Drong, R.F., Slightom, J. and Beachy, R.N.
- Publication venue
- 'Genetics Society of Japan'
- Publication date
- 01/01/2001
- Field of study
Fundamentals of Organic Agriculture – Past and Present
- Author
- A. Avery
- A. Drengson
- A. Howard
- A. Howard
- A. Naess
- A. Trewavas
- A. Trichopoulou
- A.E. Johnston
- B. Beck-Fries
- B. Freyer
- B. Söderström
- B.N. Ames
- B.N. Ames
- C.J. Green
- D. Basker
- D. Bourn
- D. Taverne
- D.H. Meadows
- D.L. Jones
- D.T. Avery
- E.A Davidson
- E.A. Balfour
- E.H.P.A. Haeckel
- F.A. Swartjes
- F.H. King
- G. Bertilsson
- G. Oshawa
- G. Torstensson
- H. Kirchmann
- H. Kirchmann
- H. Kirchmann
- H. Kirchmann
- H. Kirchmann
- H. Kirchmann
- H. Kirchmann
- H. Kirchmann
- H. Verhoog
- H.H. Koepf
- H.H. Koepf
- H.P. Rusch
- J. Balesdent
- J. Nyamangara
- J.M. Paillat
- J.W. Doran
- K. Mengel
- K. Woese
- L. Bergström
- L. Bergström
- L. Bergström
- L. Kirchmann
- L. Kristensen
- L. Vilkka
- L.R. McDowell
- M. Fukuoka
- M. Fukuoka
- M. Fukuoka
- M. Schloter
- M.C. Merrill
- M.H. Gerzabek
- M.H. Puig-Gimenez
- M.H. Ryan
- M.H. Ryan
- M.P. Bocanegra
- O. Andrén
- O. Andrén
- P. Conford
- P. Schønning
- P.A. Sanchez
- P.B. Tinker
- R. Alvarez
- R. Carson
- R. Lal
- R. Reuveni
- R. Steiner
- R. Steiner
- R.M. Welch
- R.S. Antil
- S. Bjarnason
- S. Dahlin
- S.G. Sommer
- S.L. Jansson
- S.L. Jansson
- S.L. Jansson
- S.L. Jansson
- S.M. Ullah
- T. Ahl
- T. Ingestad
- T. Näsholm
- W. Fox
- W.C. Willet
- Y. Chen
- Y. Eklind
- Z. Rengel
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2008
- Field of study
Front Instabilities and Invasiveness of Simulated Avascular Tumors
- Author
- A. Balter
- A. Brú
- A. Brú
- A. Ludwig
- A. Pocheau
- A. Qi
- A.F. Chambers
- A.J. Perumpanani
- A.R. Kansal
- A.R.A. Anderson
- A.R.A. Anderson
- A.R.A. Anderson
- A.R.A. Anderson
- A.R.A. Anderson
- Alexander R. A. Anderson
- B. Dubuc
- B. Radotra
- C. Guiot
- C. Picioreanu
- C. Picioreanu
- C. Sahlgren
- D. Bray
- D. Drasdo
- D. Hartmann
- D.A. Beysens
- E. Brener
- E. Gherardi
- E. Khain
- E.A. Clark
- E.A. Holm
- E.L. Stott
- F. Graner
- G. Chapman
- G. Christofori
- G. Forgacs
- H. Müller-Krumbhaar
- H.B. Frieboes
- H.B. Frieboes
- H.M. Byrne
- I. Stalder
- J. Bechhoefer
- J. Condeelis
- J. Dockery
- J. Folkman
- J. Folkman
- J. Klominek
- J. Lacovara
- J. Scott Gens
- J. Smolle
- J.A. Glazier
- J.A. Glazier
- J.A. Izaguirre
- J.A. Lawrence
- J.A. Sherratt
- J.B. McCarthy
- J.C. Mombach
- J.J. Casciari
- J.J. Casciari
- J.M. Lee
- J.P. Freyer
- J.P. Quigley
- J.P. Ward
- J.S. Langer
- J.S. Langer
- J.S. Rubin
- James A. Glazier
- K. Burridge
- K. Hotary
- K.A. Rejniak
- K.R. Swanson
- L. Mariani
- L. Sherwood
- L. Trusolino
- L.A. Liotta
- L.A. Liotta
- L.D. Landau
- L.M. Matrisian
- L.M. Sander
- M. Kimmel
- M. Marusic
- M.A. Huber
- M.A.J. Chaplain
- M.A.J. Chaplain
- M.E. Glicksman
- M.E. Orme
- M.G. Moore
- M.M. Melicow
- M.S. Steinberg
- M.V. Blagosklonny
- M.W. Retsky
- Maciej Swat
- N. Johansson
- N. Kumar
- N. Metropolis
- N. Stoker
- N.J. Popławski
- N.J. Popławski
- Nikodem J. Popławski
- O. Trédan
- P. Calabresi
- P. Friedel
- P. Gerlee
- P. Gerlee
- P. Gerlee
- P. Macklin
- P. Mignatti
- P. Tracqui
- P.K. Burgess
- P.R. Debruyne
- R. Chaturvedi
- R. Chaturvedi
- R. Chaturvedi
- R. Kobayashi
- R.A. Foty
- R.A. Foty
- R.A. Gatenby
- R.A. Weinberg
- R.K. Jain
- R.M.H. Merks
- R.O. Hynes
- S. Dormann
- S. Huang
- S. Koochekpour
- S. Pennacchietti
- S. Turner
- S. Turner
- S. Turner
- S.B. Carter
- S.H. Davis
- T. Miura
- T. Nakamura
- T. Nakamura
- T.A. Witten
- T.E. Wheldon
- T.M. Cickovski
- U.P. Thorgeirsson
- Ubirajara Agero
- V. Cristini
- V. Cristini
- V.P. Terranova
- W. Düchting
- W. Düchting
- W.G. Stetler-Stevenson
- W.G. Stetler-Stevenson
- X.R. Li
- Y. Jiang
- Y. Saito
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Nonlinear modeling and simulation of tumor growth
- Author
- A. Anderson
- A. Bardelli
- A. Brandt
- A. Friedman
- A. Friedman
- A. Friedman
- A. Morotti
- A. Ramanathan
- A. Sierra
- A.A. Kansal
- A.F. Jones
- A.J. Ridley
- A.K. Ommaya
- A.L. Harris
- A.M. Tester
- A.R.A. Anderson
- A.R.A. Anderson
- A.R.A. Anderson
- B. Kaur
- B.C. Sanson
- C. Boccaccio
- C. Breward
- C. Hayot
- C.P. Please
- C.S. Hogea
- D. Ambrosi
- D. Ambrosi
- D. Ambrosi
- D. Galaris
- D. Jacqmin
- D. Shweiki
- D. Zagzag
- D.G. Mallett
- D.L. Page
- D.L.S. McElwain
- D.M. Anderson
- D.M. Brizel
- E. Bullitt
- E. Maher
- E. Putz
- E. Rofstad
- E. Rofstad
- E. Sahai
- E.A. Seftor
- F. Bussolino
- F. Ravandi
- G. Batchelor
- G. Helmlinger
- G. Sakamoto
- G. Truskey
- G.T. Fallenstein
- G.W. McLean
- H. Acker
- H. Andersen
- H. Byrne
- H. Garcke
- H. Hashizume
- H. Lee
- H. Naganuma
- H. Yamaguchi
- H.B. Frieboes
- H.B. Frieboes
- H.G. Augustin
- H.J. Bloemendal
- H.J.J.A. Bernsen
- H.M. Byrne
- H.M. Byrne
- H.M. Byrne
- H.M. Byrne
- H.M. Byrne
- H.M. Byrne
- H.M. Byrne
- H.P. Greenspan
- H.P. Greenspan
- J. Adam
- J. Condeelis
- J. Holash
- J. Holash
- J. Lockett
- J. Pouysségur
- J. Rohzin
- J. Sinek
- J. Yu
- J.A. Eble
- J.A. Forsythe
- J.E. Nor
- J.L. Rubenstein
- J.P. Freyer
- J.P.B. O’Connor
- J.R. Less
- J.S. Kim
- J.S. Kim
- J.S. Kim
- J.S. Lowengrub
- J.T. Erler
- K. Date
- K. DeJaeger
- K. Garber
- K. Lamszus
- K. Wolf
- K.L. Schmeichel
- L. Bello
- L. Derycke
- L. Kopfstein
- L.C.L.T. Kempen van
- L.M. Postovit
- M. Berger
- M. Höckel
- M. Höckel
- M. Konopleva
- M. Natarajan
- M. Polette
- M. Wurzel
- M.A. Esteban
- M.A.J. Chaplain
- M.A.J. Chaplain
- M.A.J. Chaplain
- M.A.J. Chaplain
- M.A.J. Chaplain
- M.A.J. Chaplain
- M.A.J. Chaplain
- M.J. Plank
- M.J. Plank
- N. Bellomo
- N. Bellomo
- N. Festjens
- N. Paweletz
- P. Carmeliet
- P. Elvin
- P. Friedl
- P. Friedl
- P. Friedl
- P. Friedl
- P. Kunkel
- P. Macklin
- P. Macklin
- P. Macklin
- P. Macklin
- P. Michieli
- P. Vajkoczy
- P. Vaupel
- P. Vaupel
- P.A. Netti
- P.H. Leo
- P.J. Keller
- P.S. Steeg
- Q. Huang
- R. Gatenby
- R. Montesano
- R.A. Cairns
- R.A. Gatenby
- R.A. Gatenby
- R.A. Kloner
- R.A.J. Kuiper
- R.D. Lester
- R.G. Abbott
- R.K Jain
- R.K. Jain
- R.K. Jain
- R.K. Jain
- R.K. Jain
- R.K. Jain
- R.M. Sutherland
- R.P. Araujo
- R.P. Araujo
- R.P. Araujo
- S. Osher
- S. Paku
- S. Patan
- S. Pennacchietti
- S. Sanga
- S. Sanga
- S. Sun
- S. Takano
- S.A. Enam
- S.A. Skinner
- S.D. Young
- S.D. Young
- S.M. Wise
- S.M. Wise
- S.P. Yin
- S.R. McDougall
- S.R. McDougall
- T. Alarcón
- T. Roose
- T.G. Graeber
- T.P. Padera
- T.T. Lah
- T.W. Bauer
- V. Cristini
- V. Cristini
- V. Cristini
- V. Cristini
- V. Lubarda
- V. Quaranta
- W. Mueller-Klieser
- W. Tiller
- X. Li
- X. Zheng
- Y. Mansury
- Y. Saad
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2008
- Field of study
Liquid-crystalline phthalocyanine-based nanostructures
- Author
- A. Bilgin
- A. Calo
- A. Generosi
- A. Sparavigna
- A.C. Sonin
- A.G. Gurlek
- A.G. Martynov
- A.M. Craats Van de
- A.S. Cherodian
- A.Yu. Tsivadze
- A.Yu. Tsivadze
- A.Yu. Tsivadze
- B.J. Coe
- C. Nostrum Van
- C. Paleos
- C. Piechocki
- C. Sirlin
- C.C. Leznoff
- C.D. Dimitrakopoulos
- C.F. Nostrum Van
- C.J. Schramm
- C.M. Drain
- C.P. Collard
- D. Markovitsi
- D. Wrobel
- D.L.T. Gema
- E. Hamuryudan
- E. Sielcken
- E.A. Corsellis
- F. Guyon
- F. Lu
- G. Torre
- G. Torre de la
- G.W. Gray
- G.W. Gray
- H. Engelkamp
- H. Gasparoux
- H. Zhang
- I. Beletskaya
- I. Cho
- I. Guorol
- J. Jiang
- J. Padilla
- J. Simon
- J. Simon
- J. Xue
- J.-M. Lehn
- J.A. Duro
- J.A. Pranata
- J.F. Pol Van der
- J.F. Pol Van der
- J.M. Warman
- J.M. Warman
- J.S. Shirk
- J.U. Sleven
- J.U. Sleven
- J.W. Buchler
- K. Ban
- K. Binnemans
- K. Ohta
- K. Ohta
- K. Ohta
- K. Yoshino
- K.P. Birin
- L.A. Nosikova
- M. Camur
- M. Fukumasa
- M. Ichihara
- M. Nicolau
- M.A. Reed
- M.F. Grebenkin
- M.J. Cook
- M.K. Engel
- M.M. Nicholson
- M.N. Misir
- N. He
- N. Khazanovich
- N. Kobayashi
- N. Kobayashi
- N.B. Mckeown
- O. Keoysal
- P. Mouthuy
- P. Turek
- P.G. Schouten
- P.G. Schouten
- P.G. Schouten
- Q. Li
- R.A. Jones
- R.J. Bushby
- R.J. Nolte
- S. Cho
- S. Nespurek
- S. Nespurek
- S. Seelan
- S. Tantrawongs
- S. Wie
- S.J. Milder
- S.L. Selektor
- S.O. Andryushkevich
- T. Inabe
- T. Kato
- T. Sooksimuang
- T.V. Basova
- V. Coropceanu
- V.A. Molochko
- V.P. Kulinich
- W. Freyer
- W. Gopel
- W.H. Flora
- W.H. Jeu de
- W.L. Jorgensen
- X. Li
- X. Mo
- Y. Bian
- Y. Bian
- Y. Liu
- Y.-S. Kang
- Yu. Gorbunova
- Yu.G. Gorbunova
- Z. Ali-Adiba
- Z. Biyiklioglu
- Z. Biyiklioglu
- Z. Sideratou
- Publication venue
- 'Pleiades Publishing Ltd'
- Publication date
- Field of study
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
- Author
- Abecasis G. (Goncalo)
- Abecasis G.R. (Gonçalo)
- Abecasis G.R. (Gonçalo)
- Aben K.K.H. (Katja)
- Absher D. (Devin)
- Absher D. (Devin)
- Aherrahrou Z. (Zouhair)
- Ahlqvist E. (Emma)
- Ahmadi K.R. (Kourosh)
- Ahmed N. (Nabeel)
- Alavere H. (Helene)
- Alibrandi M.T.S. (Maria)
- Allayee H. (Hooman)
- Allen H.L.
- Almgren P. (Peter)
- Altshuler D. (David)
- Amin N. (Najaf)
- Anand S.S. (Sonia)
- Andersen K.K. (Karl)
- Ardissino D. (Diego)
- Ardlie K.G. (Kristin)
- Armitage J. (Jane)
- Arnold A.M. (Alice)
- Aspelund T. (Thor)
- Assimes T.L. (Themistocles)
- Assmann G. (Gerd)
- Aulchenko Y.S. (Yurii)
- Azhar M. (Muhammad)
- Balkau B. (Beverley)
- Ball S.G. (Stephen G.)
- Barbalic M. (maja)
- Barker A.M. (Adam)
- Barlassina C. (Christina)
- Barlera S. (Simona)
- Barnes D. (Daniel)
- Barnes T.A. (Timothy)
- Barrett A. (Angela)
- Barroso I.E. (Inês)
- Bataille V. (Veronique)
- Becker D.M. (Diane)
- Becker L.C. (Lewis)
- Beckmann J.S. (Jacques)
- Beckmann J.S. (Jacques)
- Beilby J.P. (John)
- Bell J.T. (Jordana)
- Ben-Shlomo Y.
- Ben-Shlomo Y. (Yoav)
- Bennett A.J. (Amanda)
- Berger K. (Klaus)
- Bergman R.N. (Richard N.)
- Bergmann S.M. (Sven)
- Berndt S.I. (Sonja)
- Biebermann H. (Heike)
- Bis J.C. (Joshua)
- Blagieva R. (Roza)
- Blakemore A.I.F. (Alexandra)
- Blankenberg S. (Stefan)
- Boehm B.O. (Bernhard)
- Boehm B.O. (Bernhard)
- Boehnke M. (Michael)
- Boeing H. (Heiner)
- Boeing H. (Heiner)
- Boekholdt S.M. (Matthijs)
- Boerwinkle E.A. (Eric)
- Boes T. (Tanja)
- Bonnycastle L.L. (Lori)
- Boomsma D.I. (Dorret)
- Borecki I.B. (Ingrid)
- Bornstein S.R. (Stefan R.)
- Bornstein S.R. (Stefan)
- Boström K.B. (Kristina Bengtsson)
- Bouatia-Naji N. (Nabila)
- Bowman L.
- Braund P.S. (Peter)
- Bravenboer B. (Bert)
- Buchanan T.A. (Thomas)
- Bumpstead S. (Suzannah)
- Burnett M.S.
- Burtt N.P. (Noël)
- Busonero F.
- Buysschaert I. (Ian)
- Cambien F. (François)
- Campbell H. (Harry)
- Cappuccio F.P. (Francesco P.)
- Cappuccio F.P. (Francesco)
- Carlquist J.F. (John)
- Cauchi S. (Stephane)
- Caulfield M. (Mark)
- Cavalcanti-Proença C. (Christine)
- Chambers J.C. (John C.)
- Chambers J.C. (John)
- Chanock S.J. (Stephen)
- Charpentier G. (Guillaume)
- Chasman D.I. (Daniel)
- Chatterjee N. (Nilanjan)
- Chen C.-M. (Chih-Mei)
- Chen H. (Han)
- Chen L. (Li)
- Chines P.S. (Peter)
- Cichon S. (Sven)
- Clarke R.
- Clarke R. (Robert)
- Codd V. (Veryan)
- Coin L. (Lachlan)
- Coin L. (Lachlan)
- Collins F.S. (Francis S.)
- Collins F.S. (Francis)
- Collins F.S. (Francis)
- Connell J. (John)
- Cooper C. (Charles)
- Cooper C.C. (Cyrus C.)
- Cooper M.N. (Matthew N.)
- Cooper M.N. (Matthew)
- Cornelis M. (Marilyn)
- Couper D.J. (David)
- Crawford G. (Gabe)
- Cupples L.A. (Adrienne)
- Daly M.J. (Mark)
- Dam R.M. (Rob) van
- Danesh J. (John)
- Davies R.W. (Robert)
- Day I.N.M. (Ian N.M.)
- Day I.N.M. (Ian)
- Dedoussis G.V. (George)
- Dedoussis G.V. (George)
- Dedoussis G.V. (George)
- Dehghan A. (Abbas)
- Deloukas P. (Panagiotis)
- Demissie S. (Serkalem)
- Den Heijer M. (Martin)
- Dennison E.M. (Elaine)
- Dermitzakis E.T. (Emmanouil T.)
- Devaney J.M. (Joseph M.)
- Di Meglio P. (Paola)
- Diemert P. (Patrick)
- Dimas A.S. (Antigone)
- Dina C. (Christian)
- Dixon A.L. (Anna)
- Do R. (Ron)
- Doering A. (Angela)
- Doney A.S.F. (Alex)
- Donnelly P. (Peter)
- Duan J. (Jubao)
- Duijn C.M. (Cornelia) van
- Dupuis J. (Josée)
- Durbin R. (Richard)
- Ebrahim S. (Shah)
- Ebrahim S. (Shanil)
- Eifert S. (Sandra)
- Eiriksdottir G. (Gudny)
- El Mokhtari N.E. (Nour Eddine)
- Elliott A.L. (Amanda)
- Elliott K.S. (Katherine)
- Elliott P. (Paul)
- Ellis S.G. (Stephen)
- Elosua R. (Roberto)
- Engert J.C. (James C.)
- Epstein S.E. (Stephen)
- Erdmann J. (Jeanette)
- Erdos M.R. (Michael)
- Eriksson P. (Per)
- Esko T. (Tonu)
- Esko T. (Tõnu)
- Estrada Gil K. (Karol)
- Eury E. (Elodie)
- Faire U. (Ulf) de
- Farooqi I.S. (I. Sadaf)
- Farooqi I.S. (Sadaf)
- Farrall M. (Martin)
- Feitosa M.F. (Mary Furlan)
- Felix S.B. (Stephan)
- Ferrannini E. (Ele)
- Ferreira T. (Teresa)
- Fischer M. (Marcus)
- Fischer-Posovszky P. (Pamela)
- Florez J.C. (Jose)
- Folkersen L. (Lasse)
- Folsom A.R. (Aaron)
- Forsen T. (Tom)
- Fox C.S. (Caroline)
- Franklin C.S. (Christopher)
- Frants R.R. (Rune)
- Franzosi M.
- Frayling T.M. (Timothy)
- Freimer N.B. (Nelson B.)
- Freyer J. (Jennifer)
- Friedrich N. (Nele)
- Froguel P. (Philippe)
- Frossard R.
- Fu M. (Mao)
- Gaget S. (Stefan)
- Ganser M. (Martha)
- Gardezi A. (Ali)
- Gejman P.V. (Pablo)
- Geus E.J. (Eeco)
- Gieger C. (Christian)
- Gigante B. (Bruna)
- Girelli D. (Domenico)
- Gjesing A.P. (Anette)
- Glass D. (Daniel)
- Glazer N.L. (Nicole)
- Gloyn A.L. (Anna)
- Goddard M.E. (Michael E.)
- Goddard M.E. (Michael)
- Goel A. (Anuj)
- Goodall A.H. (Alison)
- Goyette P. (Philippe)
- Grallert H. (Harald)
- Grarup N. (Niels)
- Green F. (Fiona)
- Green T. (Todd)
- Greenawalt D.M. (Danielle M.)
- Griffin S. (Simon)
- Groop L. (Leif)
- Groop L. (Leif)
- Groop L. (Leif)
- Groves C.J. (Christopher)
- Grundberg E. (Elin)
- Gräsler J. (Jürgen)
- Grönberg H. (Henrik)
- Gu H.F. (Harvest F.)
- Gudnason V. (Vilmundur)
- Gudnason V. (Vilmundur)
- Guiducci C. (Candace)
- Gulcher J.R. (Jeffrey)
- Gustafsson S. (Stefan)
- Gyllensten U. (Ulf)
- Hadjadj S. (Samy)
- Haeften T.W. (Timon) van
- Hagen K. (Knut)
- Hall A.S. (Alistair S.)
- Hall P. (Per)
- Halperin E. (Eran)
- Hammond C.J. (Christopher J.)
- Hammond C.J. (Christopher)
- Hammond N. (Naomi)
- Hamsten A. (Anders)
- Hansen T. (T.)
- Haritunians T. (Talin)
- Harris T.B. (Tamara)
- Hartikainen A.-L. (Anna-Liisa)
- Hassanali N. (Neelam)
- Hattersley A.T. (Andrew)
- Havulinna A.S. (Aki)
- Hayes R.B. (Richard)
- Hayes R.B. (Richard)
- Hayward C. (Caroline)
- Hazen S.L. (Stanley)
- Heard-Costa N.L. (Nancy)
- Heath A.C. (Andrew C.)
- Hebebrand J. (Johannes)
- Hedman A.K. (Asa)
- Heid I.M. (Iris)
- Heijer M. (Martin) den
- Heinrich J. (Joachim)
- Hellénius M.-L. (Mai-Lis)
- Hengstenberg C. (Christian)
- Herder C. (Christian)
- Herpt T.W. (Thijs) van
- Hicks A.A. (Andrew)
- Hide W.A. (Winston)
- Hinney A. (Anke)
- Hirschhorn J.N. (Joel)
- Hitman G.A. (Graham)
- Hoek M. (Mandy) van
- Hoesel V. (Volker)
- Hofman A. (Albert)
- Hofmann O.M. (Oliver)
- Holm H. (Hilma)
- Homuth G. (Georg)
- Hopewell J.
- Horikoshi M. (Momoko)
- Hottenga J.J. (Jouke Jan)
- Hu F.B. (Frank)
- Hui J. (Jennie)
- Huikuri H.V. (Heikki)
- Hunter D.J. (David J.)
- Huth C. (Cornelia)
- Hveem K. (Kristian)
- Igl W. (Wilmar)
- Illig T. (Thomas)
- Illig T. (Thomas)
- Ingelsson E. (Erik)
- Iribarren C. (Carlos)
- Ishaq M. (Muhammad)
- Isomaa B. (Bo)
- Jackson A.U. (Anne)
- Jacobs K.B. (Kevin)
- James A. (Alan)
- Jameson K. (Karen)
- Jansson J.-O. (John-Olov)
- Jarick I. (Ivonne)
- Jarvelin M.-R. (Marjo-Riitta)
- Jewell E. (Eelizabeth)
- Johansson A. (Asa)
- John U. (Ulrich)
- Johnson P. (Paul)
- Johnson P.R.V. (Paul R.V.)
- Johnson T. (Toby)
- Johnson T. (Toby)
- Jones G.T. (Gregory)
- Jorgensen T. (Torben)
- Jousilahti P. (Pekka)
- Jukema J.W. (Jan Wouter)
- Jula A. (Antti)
- Kaakinen M. (Marika)
- Kajantie E. (Eero)
- Kanoni S. (Stavroula)
- Kao W.H.L. (Wen)
- Kaplan L. (Lee)
- Kaplan R.C. (Robert)
- Kaprio J. (Jaakko)
- Kaprio J. (Jaakko)
- Karpe F. (Fredrik)
- Karpe F. (Fredrik)
- Kastelein J.J.P. (John)
- Kathiresan S. (Sekar)
- Kerr-Conte J. (Julie)
- Kettunen J. (Johannes)
- Khaw K.T.
- Kiemeney L.A.L.M. (Bart)
- Kilpeläinen T.O. (Tuomas)
- Klopp N. (Norman)
- Knowles J.W. (Joshua)
- Kolovou G. (Genovefa)
- Kong A. (Augustine)
- Kooner J.S. (Jaspal S.)
- Kooner J.S. (Jaspal S.)
- Kooner J.S. (Jaspal)
- Koskinen S. (Seppo)
- Kovacs P. (Peter)
- Kraft P. (Peter)
- Krude H.
- Kutalik Z. (Zoltán)
- Kuusisto J. (Johanna)
- Kyriakou T. (Theodosios)
- Kähönen M. (Mika)
- König I.R. (Inke)
- Laakso M. (Markku)
- Laaksonen R. (Reijo)
- Laitinen J. (Jaana)
- Lambrechts D. (Diether)
- Lamina C. (Claudia)
- Langenberg C. (Claudia)
- Lantieri O. (Olivier)
- Lanzani C. (Chiara)
- Launer L.J. (Lenore)
- Lauritzen T. (Torsten)
- Lawlor D.A. (Debbie)
- Lawrence R.W. (Robert)
- Lecoeur C. (Cécile)
- Lehtimäki T. (Terho)
- Lettre G. (Guillaume)
- Levinson D.F. (Douglas F.)
- Levinson D.F. (Douglas)
- Li M. (Man)
- Li S. (Shengxu)
- Li X. (Xiaohui)
- Liang L. (Liming)
- Lieb W. (Wolfgang)
- Lieverse A.G. (Aloysius)
- Linksted P. (Pamela)
- Liu J. (Jianjun)
- Liu J. (Jianjun)
- Lokki M.L.
- Loley C. (Christina)
- Loos R.J.F. (Ruth)
- Lorentzon M. (Mattias)
- Lotery A.J. (Andrew)
- Luan J.
- Ludwig B. (Barbara)
- Lyssenko V. (Valeriya)
- Macciardi F. (Fabio)
- Makrilakis K. (Konstantinos)
- Mallick C.B. (Chandana Basu)
- Mannila M.N. (Maria Nastase)
- Manning A.K. (Alisa)
- Mannucci P.M. (Pier)
- Manunta P. (Paolo)
- Maouche S. (Seraya)
- Marek D. (Diana)
- Marre M. (Michel)
- Martin N.G. (Nicholas)
- Martinez-Larrad M.T. (Maria Teresa)
- McCarroll S.A. (Steven)
- McCarthy A. (Anne)
- McCarthy M. (Mark)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark)
- McCulloch L.J. (Laura)
- McKnight B. (Barbara)
- McPherson R. (Ruth)
- Meigs J.B. (James)
- Meisinger C. (Christa)
- Meitinger T. (Thomas)
- Melander O. (Olle)
- Merlini P.A. (Pier Angelica)
- Metspalu A. (Andres)
- Meyre D. (David)
- Midthjell K. (Kristian)
- Min J. (Josine)
- Mohlke K.L. (Karen L.)
- Monda K.L. (Keri)
- Montgomery G.W. (Grant)
- Montgomery G.W. (Grant)
- Mooser V. (Vincent)
- Morgan T. (Thomas)
- Morken M.A. (Mario)
- Morris A.D. (Andrew)
- Morris A.P. (Andrew)
- Muhlestein J.B. (Joseph)
- Mulic R. (Rosanda)
- Munroe P. (Patricia)
- Munroe P.B. (Patricia B.)
- Munzel T. (Thomas)
- Musunuru K. (Kiran)
- Myers R.H. (Richard)
- Mägi R. (Reedik)
- Mälarstig A. (Anders)
- März W. (Winfried)
- Nahrstaedt J. (Janja)
- Narisu N. (Narisu)
- Narisu N. (Narisu)
- Navarro P. (Pau)
- Nelis M. (Mari)
- Nelson C.P. (Christopher P.)
- Nemesh J. (James)
- Nestle F.O. (Frank)
- Neville M.J. (Matthew)
- Ngwa J.S.
- Nica A. (Alexandra)
- Nieminen M.S. (Markku)
- Nilsson P. (Peter)
- Nisbet J. (James)
- North K.E. (Kari)
- Nyholt D.R. (Dale)
- Nöthen M.M. (Markus)
- O'Connell J.R. (Jeffrey R.)
- O'Donnell C.J. (Christopher)
- O'Rahilly S. (Stephen)
- O'Rahilly S. (Stephen)
- O'Rahilly S. (Steve)
- Offer A. (Alison)
- Ohlsson C. (Claes)
- Olivieri O. (Oliviero)
- Olsson G.
- Ongen H. (Halit)
- Oostra B.A. (Ben)
- Osmond C. (Clive)
- Ouwehand W.H. (Willem)
- Owen K.R. (Katharine)
- O´Connell J.R.
- Palmer C.N.A. (Colin)
- Pankow J.S. (James)
- Pare G. (Guillame)
- Park J.H.
- Parker A.N. (Alex)
- Parts L. (Leopold)
- Pascoe L. (Laura)
- Patel R.S. (Riyaz)
- Patterson C.C. (Chris C.)
- Payne F. (Felicity)
- Peden J. (John)
- Pedersen O. (Oluf)
- Pellikka N. (Niina)
- Peltonen L. (Leena Johanna)
- Penninx B.W.J.H.
- Perola M. (Markus)
- Perola M. (Markus)
- Perry J.R.B. (John)
- Peters A. (Annette)
- Peters M.J. (Marjolein)
- Petersen A.K.
- Peto R. (R.)
- Petrie J.R. (John)
- Peyvandi F. (Flora)
- Pichler I. (Irene)
- Pietilainen K.H. (Kirsi Hannele)
- Platou C. (Carl)
- Platou C.P. (Carl)
- Polasek O. (Ozren)
- Potter S.C. (Simon)
- Pramstaller P.P. (Peter P.)
- Preuss M. (Michael)
- Proença C. (Christine)
- Prokopenko I. (Inga)
- Prokopenko I. (Inga)
- Purcell S. (Shaun)
- Qi L. (Lu)
- Quertermous T. (Thomas)
- Quyyumi A.A. (Arshed)
- Rader D.J. (Daniel)
- Rafelt S. (Suzanne)
- Raitakari O. (Olli)
- Raitakari O.T. (Olli T.)
- Rallidis L.S. (Loukianos)
- Randall J.C. (Joshua)
- Rasheed A. (Asif)
- Rathmann W. (Wolfgang)
- Rathmann W. (Wolfgang)
- Raychaudhuri S. (Soumya)
- Rayner N.W. (N. William)
- Rayner N.W. (Nigel William)
- Reilly M.P. (Muredach P.)
- Reinehr T. (Thomas)
- Ridderstråle M. (Martin)
- Ridker P.M. (Paul)
- Rij A.M. (Andre) van
- Ripatti S. (Samuli)
- Rissanen A. (Aila)
- Rivadeneira Ramirez F. (Fernando)
- Roberts R. (Robert)
- Rocheleau G. (Ghislain)
- Roden M. (Michael)
- Rosendaal F.R. (Frits R.)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Rust S. (Stephan)
- Rybin D. (Denis)
- Rzehak P. (Peter)
- Sabater-Lleal M. (Maria)
- Saleheen D. (Danish)
- Salomaa V. (Veikko)
- Samad A. (Adbus)
- Samani N.J. (Nilesh)
- Samani N.J. (Nilesh)
- Sampietro M.L. (Maria Lourdes)
- Sampson M.J. (Michael)
- Samuel M. (Maria)
- Sanders A.R. (Alan R.)
- Sandholt C. (Camilla)
- Sandhu M.S. (Manjinder)
- Sandhu M.S. (Manjinder)
- Sanna S. (Serena)
- Saramies J. (Jouko)
- Savolainen M.J. (Markku)
- Saxena R. (Richa)
- Sayer A.A.
- Schadt E.E. (Eric)
- Scherag A. (Andre)
- Schillert A. (Arne)
- Schipf S. (Sabine)
- Schlessinger D. (David)
- Schreiber S. (Stefan)
- Schrezenmeir J. (Jürgen)
- Schunkert H. (Heribert)
- Schwartz S.M. (Stephen)
- Schwarz P.E.H. (Peter)
- Schäfer A. (Arne)
- Scott J. (James)
- Scott L.J. (Laura)
- Scott L.J. (Laura)
- Seedorf U. (Udo)
- Segrè A.V. (Ayellet)
- Sehmi J.S. (Joban)
- Sekowska M. (Magdalena)
- Sennblad B. (Bengt)
- Serrano-Ríos M. (Manuel)
- Shah N. (Nisha)
- Shi J. (Jianxin)
- Shi J. (Jianxin)
- Shields B.M. (Beverley)
- Shields B.M. (Beverley)
- Shrader P. (Peter)
- Shuldiner A.R. (Alan)
- Shuldiner A.R. (Alan)
- Sigurdsson G. (Gunnar)
- Sijbrands E. (Eric)
- Sijbrands E.J.G. (Eric)
- Silander K. (Kaisa)
- Sinisalo J. (Juha)
- Siscovick D.S. (David)
- Sivapalaratnam S. (Suthesh)
- Sladek R. (Rob)
- Sleight P. (Peter)
- Smit J.H. (Jan)
- Smith A.V. (Albert Vernon)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith T.B. (Tamara B.)
- Snoep J.D. (Jaapjan)
- Soranzo N. (Nicole)
- Sparsø T. (Thomas)
- Spector T.D. (Timothy)
- Speliotes E.K. (Elizabeth)
- Spertus J.A. (John)
- Stančcáková A. (Alena)
- Stark K. (Klaus)
- Stein L.D. (Lincoln)
- Steinthorsdottir V. (Valgerdur)
- Stephens J. (Jonathan)
- Stewart A.F. (Alexandre F.)
- Stirrups K. (Kathy)
- Stoll M. (Monika)
- Strachan D.P. (David)
- Strassburger K. (Klaus)
- Strawbridge R.J. (Rona)
- Strawbridge R.J. (Rona)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Sun Q. (Qi)
- Surdulescu G. (Gabriela)
- Swift A.J. (Amy)
- Syvänen A.C.
- Tammesoo M.L.
- Taneera J. (Jalal)
- Tang W. (W.)
- Tardif J.-C. (Jean-Claude)
- Tennstedt S. (Stephanie)
- Teslovich T.M. (Tanya M.)
- Thiering E. (Eelisabeth)
- Thiering E. (Elisabeth)
- Thompson J.R. (John)
- Thomson B. (Brian)
- Thorand B. (Barbara)
- Thorand B. (Barbara)
- Thorgeirsson G. (Gudmundur)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Tichet J. (Jean)
- Timpson N.J. (Nicholas)
- Tognoni G.
- Tomaszewski M. (Maciej)
- Travers M.E. (Mary E.)
- Travers M.E. (Mary)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Turrini F. (Fabiola)
- Tyrer J.P. (Jonathan)
- Tönjes A. (Anke)
- Uda M. (Manuela)
- Uitterlinden A.G. (André)
- Valle T.T. (Timo T.)
- Van Dam R.M. (Rob M.)
- van't Hooft F. (Ferdinand)
- Van't Hooft F. (Ferdinand)
- Vatin V. (Vincent)
- Vedantam S. (Sailaja)
- Visscher P.M. (Peter M.)
- Visscher P.M. (Peter)
- Vitart V. (Veronique)
- Vliet-Ostaptchouk J.V. (Jana) van
- Voight B.F. (Benjamin)
- Wabitsch M. (Martin)
- Waeber G. (Gérard)
- Waite L. (Lindsay)
- Walker M. (Mark)
- Wallaschofski H. (Henri)
- Walters G.B. (Bragi)
- Wareham N.J. (Nicholas J.)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R. (Ryan)
- Welch R.P. (Ryan)
- Wells G.A. (George)
- Weyant R.J. (Robert)
- Wheeler E. (Eleanor)
- White C.C. (Charles)
- Wichmann H.-E. (H-Erich)
- Wichmann H.E. (Heinz Erich)
- Widen E. (Elisabeth)
- Wiegand S. (Susanna)
- Wijmenga C. (Cisca)
- Wiklund F. (Fredrik)
- Wild P.S. (Philipp)
- Wild S.H. (Sarah)
- Wilk A. (Alicja)
- Willemsen G.A.H.M. (Gonneke)
- Willenborg C. (Christina)
- Willer C.J. (Cristen)
- Wilson J.F. (James F.)
- Wingerden S. (Sophie) van
- Winkler T.W. (Thomas W.)
- Witte D.R. (Daniel R.)
- Witte D.R. (Deniel)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C.M.)
- Wood A.R. (Andrew)
- Workalemahu T. (Tsegaselassie)
- Wright A.F. (Alan)
- Wright B.J. (Benjamin)
- Wu G. (Guanming)
- Xie W. (Weijia)
- Xu J. (Jianfeng)
- Yang J. (Jian)
- Yang J. (Joanna)
- Yang T.-P. (Tsun-Po)
- Ye S. (Shu)
- Zabena C. (Carina)
- Zaidi M.A. (Aghar)
- Zaman K.S. (Khan Shah)
- Zeggini E. (Eleftheria)
- Zeller T. (Tanja)
- Zethelius B. (Björn)
- Zgaga L. (Lina)
- Zhang Q. (Qunyuan)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zitting P. (Paavo)
- Zondervan K.T. (Krina T.)
- Zondervan K.T. (Krina)
- Zwart J-A. (John-Anker)
- Öhrvik J. (John)
- Östenson C.-G. (Claes-Göran)
- Publication venue
- Publication date
- 01/10/2011
- Field of study
OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10-8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/ C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 3 10-4), improved b-cell function (P = 1.1 × 10-5), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10-6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS - We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis