Effect of biodegradation processes on the composition and structure of asphaltenes in West Siberian oils

NMR spectroscopy in combination with elemental analysis was used to study asphaltenes in biodegraded oils from Cenomanian pools of West Siberia. The sampling depths vary from 680 to 1800 m, formation temperatures – from 40°C to 70°C. For comparison, we used the data on asphaltenes in non-biodegraded oils of different genotypes. Given that biodegraded oils are very heavy (density: 910-950 kg/m3), they are characterized by high boiling point temperatures (145-270°C). Due to the loss of hydrocarbon components, they have higher resin and asphaltene content (9-20%) compared to non-degraded samples. Elemental analysis of asphaltenes in biodegraded and unaltered oils of different genotypes revealed an increasing trend for oxygen content in the asphaltenes from biodegraded samples, which may result from the oxidation of structural blocks of asphaltenes during microbial oxidation. It was shown that the aromaticity of the moderately biodegraded terrestrial-aquatic Novoaganskaya samples tends to increase with a decrease in asphaltene saturation, suggesting that the redistribution of structural groups of asphaltenes may be caused by biodegradation processes. High saturation of asphaltenes in strongly biodegraded Gubkinskaya and Novoportovskaya oils, along with a high degree of substitution of aromatic compounds in asphaltenes in Gubkinkaya oils (terrestrial and aquatic-terrestrial genotype) can be attributed to the formation of asphaltenes during strong biodegradation of hydrocarbon components in these oils

Sip-1 mutations cause disturbances in the activity of NMDA- and AMPA-, but not kainate receptors of neurons in the cerebral cortex

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(Rare types of tetrahedrite-tennantite ores of a gold ore deposit.

These sulphosalts occur as: 1) tiny segregations in sphalerite, galena and pyrite; 2) thin veinlets cutting these minerals; 3) rims on these minerals and 4) irregular intergrowths with chalcopyrite. Probe analyses of 23 grains shows that the Zn contents of these tetrahedrites and tennantites range 0.2-8.1%, with the Zn per formula unit often >1. Almost all samples contain Ag, several with Ag >2 wt.%; based on the As/Sb ratio, both argentian tennantite and argentian tetrahedrite occur. Goldfieldite-tetrahedrite solid solutions are also reported. High-tellurium tetrahedrite-tennantite and zincian tennantite contain Bi 0.1-1.2%, but one sample has Bi 10.9 wt.%, corresponding with annivite-tetrahedrite. Spectral reflectance curves and XRD data are reported.-R.A.H

Clinical symptom complexes in the diagnosis of renal kidney tumors in children

E.A. Karavaeva1, T.E. Taranushenko2, M.V. Borisova 1 1Krasnoyarsk Regional Clinical Center for Maternal and Child Welfare, Krasnoyarsk, Russian Federation 2Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation Aim: to present data on kidney tumor clinical patterns and leading symptom sets at the examination stage in the tertiary care (specialized department in a hospital setting) based on modern diagnostic methods for the detection of kidney tumors. Patients and Methods: this paper presents the results of a pilot study concerning the patterns of renal tumors (including nephroblastoma) in children and adolescents living in the Krasnoyarsk Territory. The data obtained are necessary for solving scientific and practical tasks to improve the provision of medical care in this pathology. The case histories of 57 children and adolescents with renal tumors who were hospitalized for examination and treatment in the Department of Oncology and Hematology (Krasnoyarsk Regional Clinical Center for Maternal and Child Welfare) from 2011 to 2021 were analyzed. All patients lived on the territory of the Krasnoyarsk Territory. Results and Discussion: the study, conducted for the first time in the Krasnoyarsk Territory, presented the main symptom set of renal tumors in children, including clinical manifestations, as well as data of laboratory and instrumental research methods at the stage of primary tumor diagnosis. The most common specific clinical manifestation of the renal tumor was palpable volumetric mass of the abdominal cavity and abdominal volume increase, which was consistent with the literature data. Abdominal pain and anemia were most common among the non-specific symptoms. Ultrasound showed high efficiency for the primary tumor diagnosis, while computer and contrast-enhanced magnetic resonance imaging proved to be indispensable for the clinical tumor assessment (its spread and metastasis) for more rational treatment tactics. Conclusions: information about clinical manifestations (given the specific and non-specific symptoms), concomitant pathology, data from instrumental and laboratory research methods at the stage of primary tumor diagnosis in children living in Eastern Siberia were presented for the first time. Keywords: nephroblastoma, Wilms tumor, renal tumors, kidney tumors in children, specific and non-specific symptoms, SIOP studies, hematological and oncological diseases in children. For citation: Karavaeva E.A., Taranushenko T.E., Borisova M.V. Clinical symptom complexes in the diagnosis of kidney tumors in children. Russian Journal of Woman and Child Health. 2023;6(3):304–309 (in Russ.). DOI: 10.32364/2618-8430-2023-6-3-14. </p

(Rare types of tetrahedrite-tennantite ores of a gold ore deposit.

These sulphosalts occur as: 1) tiny segregations in sphalerite, galena and pyrite; 2) thin veinlets cutting these minerals; 3) rims on these minerals and 4) irregular intergrowths with chalcopyrite. Probe analyses of 23 grains shows that the Zn contents of these tetrahedrites and tennantites range 0.2-8.1%, with the Zn per formula unit often >1. Almost all samples contain Ag, several with Ag >2 wt.%; based on the As/Sb ratio, both argentian tennantite and argentian tetrahedrite occur. Goldfieldite-tetrahedrite solid solutions are also reported. High-tellurium tetrahedrite-tennantite and zincian tennantite contain Bi 0.1-1.2%, but one sample has Bi 10.9 wt.%, corresponding with annivite-tetrahedrite. Spectral reflectance curves and XRD data are reported.-R.A.H

Reaction of 1,2,3,4-tetrahydro-2,4,5-trimethylpyrrolo[1,2-c]pyrimidine and its 7-formyl-substituted derivative with nitric acid

1,2,3,4-Tetrahydro-2,4,5-triniethylpyrrolo[1,2-c]pyrimidine and its 7-formyl derivative when treated with nitric acid are converted to substituted tetrahydropyrrolo-[1,2-c]pyrimidine-7-carboxylic acid. Conversion occurs through opening of the aminal moiety and formylation of the second molecule of tetrahydropyrrolo[1,2-c]pyrimidine by formaldehyde formed to the 7-formyl-substituted derivative. ©1999 KluwerAcademic/Plenum

Reaction of 1,2,3,4-tetrahydro-2,4,5-trimethylpyrrolo[1,2-c]pyrimidine and its 7-formyl-substituted derivative with nitric acid

1,2,3,4-Tetrahydro-2,4,5-triniethylpyrrolo[1,2-c]pyrimidine and its 7-formyl derivative when treated with nitric acid are converted to substituted tetrahydropyrrolo-[1,2-c]pyrimidine-7-carboxylic acid. Conversion occurs through opening of the aminal moiety and formylation of the second molecule of tetrahydropyrrolo[1,2-c]pyrimidine by formaldehyde formed to the 7-formyl-substituted derivative. ©1999 KluwerAcademic/Plenum