INDICATORS OF ANTICOAGULATIVE ACTIVITY OF VASCULAR WALL DEPENDING ON STAGE OF BREAST CANCER

Objective: Detection the intensity of changes in the anticoagulant activity of the vascular wall, depending on the stage of breast cancer. Methods: Study of the hemostasis system carried out in 84 women who had medical treatment in the Oncology Department of the Road Clinical Hospital with a diagnosis of breast cancer and received chemotherapy, radiation therapy and surgical treatment in various combinations. The comparison group consisted of 35 women without oncological pathology of the same age. Results: According to the results of the cuff test, the most pronounced inhibition of the ability of the endothelium to produce activators of fibrinolysis, anticoagulants and antiplatelet agents before and after the operation revealed in patients with stage II and III of the tumour process Conclusion: The revealed changes in the anticoagulant activity of the vascular wall indicate an increased risk of thrombogenic complications after surgical intervention in patients with stage II and III breast cancer

ИНФОРМАЦИОННАЯ СИСТЕМА «ВСЕРОССИЙСКИЙ РЕЕСТР ГРЫЖ»

Hernia is a widespread and common disease. In recent years, the effectiveness of surgical treatment has remained at the same level, despite the introduction of various surgical procedures, the development of endovideo surgical approaches, and the use of synthetic materials. The purpose of this study is to create the structure of the information system “All-Russian hernia registry”. A design solution has been developed, within the framework of which the categories of users are distinguished and the functionality is delineated for each category. This distinction allows you to conveniently structure information. A card is generated for each patient. It contains links to each hernia of this patient, corresponding to this operation and treatment. Also in the patient's card information is formalized that can have an indirect effect on the occurrence of a hernia. For example, risk factors contain information about bad habits of a sports or sedentary lifestyle. There are data of concomitant diseases and drug intolerances in the patient profile. The questionnaire also indicates the patient's place of residence, which from an economic point of view can affect the patient's work and lifestyle. All this information for a group of patients forms statistical ratings, makes information more accessible to patients and stimulates hospitals to develop modern technologies that improve the quality of surgical treatment, and to quickly spread positive experience.Грыжа является широко распространённым и часто встречающимся заболеванием. В последние годы эффективность оперативного лечения остаётся на одном уровне, несмотря на введение различных методик операций, разработку эндовидеохирургических доступов, применение синтетических материалов. Целью этого исследования является создание структуры информационной системы «Всероссийский реестр грыж». Разработано проектное решение, в рамках которого выделены категории пользователей и для каждой категории разграничены функциональные возможности. Такое разграничение позволяет удобным образом структурировать информацию. Формируется карта на каждого пациента, в которой закреплены ссылки на каждую грыжу этого пациента, соответствующие этому операции и лечение. Также в карте пациента формализована его личная информация и сведения, которые могут оказывать косвенное воздействие на возникновение грыжи. Например, факторы риска содержат сведения о вредных привычках спортивном или сидячем образе жизни. Есть в анкете пациента данные о сопутствующих заболеваниях и непереносимости лекарств. Также в анкете указано место проживание пациент, которое с экономической точки зрения может влиять на работу и образ жизни пациента. Все эти сведения для группы пациентов образуют статистические рейтинги, делают информацию более доступной для пациентов и стимулируют больницы к развитию современных технологий, улучшающих качество оперативного лечения, к быстрому распространению положительного опыта

Water Reservoirs in Small Planetary Bodies: Meteorites, Asteroids, and Comets

Asteroids and comets are the remnants of the swarm of planetesimals from which the planets ultimately formed, and they retain records of processes that operated prior to and during planet formation. They are also likely the sources of most of the water and other volatiles accreted by Earth. In this review, we discuss the nature and probable origins of asteroids and comets based on data from remote observations, in situ measurements by spacecraft, and laboratory analyses of meteorites derived from asteroids. The asteroidal parent bodies of meteorites formed ≤4 Ma after Solar System formation while there was still a gas disk present. It seems increasingly likely that the parent bodies of meteorites spectroscopically linked with the E-, S-, M- and V-type asteroids formed sunward of Jupiter's orbit, while those associated with C- and, possibly, D-type asteroids formed further out, beyond Jupiter but probably not beyond Saturn's orbit. Comets formed further from the Sun than any of the meteorite parent bodies, and retain much higher abundances of interstellar material. CI and CM group meteorites are probably related to the most common C-type asteroids, and based on isotopic evidence they, rather than comets, are the most likely sources of the H and N accreted by the terrestrial planets. However, comets may have been major sources of the noble gases accreted by Earth and Venus. Possible constraints that these observations can place on models of giant planet formation and migration are explored