13 research outputs found
ΠΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΡΠ΅ Π²Π°ΠΊΡΠΈΠ½Ρ: ΠΎΡ ΠΊΠ°ΠΏΡΡΠ»ΡΠ½ΡΡ ΠΏΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄ΠΎΠ² Π΄ΠΎ ΠΏΡΠΎΡΠ΅Π°Π·
Microbial capsular polysaccharides for many years provided a highly practical public health vaccines for preventing meningococcal, pneumococcal and Haemophilus influenza infection, and typhoid fever. Their application in the form of conjugates with protein carriers eliminate the gap in protection against these infections in children under one year. Extremely promising turned out offered us a new generation of vaccines, which have synthetic peptides conjugated to a meningococcal polysaccharide. Thus, new approaches to the solution of the problem of meningococcal disease vaccination serogroup B were open. In recent years, Russian researchers first suggested to use IgA1 protease (one of the major virulence factors of microbes and almost identical for mentioned below infections) for prevention of such diseases as meningococcal of all serogroups, pneumococcus and hemophilia infections. Patented processes for producing of the vaccine define domestic priority of its production and use.ΠΠΈΠΊΡΠΎΠ±Π½ΡΠ΅ ΠΊΠ°ΠΏΡΡΠ»ΡΠ½ΡΠ΅ ΠΏΠΎΠ»ΠΈΡΠ°Ρ
Π°ΡΠΈΠ΄Ρ Π½Π° ΠΏΡΠΎΡΡΠΆΠ΅Π½ΠΈΠΈ ΠΌΠ½ΠΎΠ³ΠΈΡ
Π»Π΅Ρ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π»ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΠ΅ Π²ΡΡΠΎΠΊΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ Π²Π°ΠΊΡΠΈΠ½Π°ΠΌΠΈ Π΄Π»Ρ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΡΡ
, ΠΏΠ½Π΅Π²ΠΌΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΡΡ
, Π³Π΅ΠΌΠΎΡΠΈΠ»ΡΠ½ΡΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ ΠΈ Π±ΡΡΡΠ½ΠΎΠ³ΠΎ ΡΠΈΡΠ°. Π ΠΈΡ
ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π² Π²ΠΈΠ΄Π΅ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ² Ρ Π±Π΅Π»ΠΊΠΎΠ²ΡΠΌΠΈ Π½ΠΎΡΠΈΡΠ΅Π»ΡΠΌΠΈ Π»ΠΈΠΊΠ²ΠΈΠ΄ΠΈΡΠΎΠ²Π°Π»ΠΎ ΠΏΡΠΎΠ±Π΅Π» ΠΏΡΠΈ Π·Π°ΡΠΈΡΠ΅ ΠΎΡ ΡΡΠΈΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ Π΄Π΅ΡΠ΅ΠΉ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ Π΄ΠΎ ΠΎΠ΄Π½ΠΎΠ³ΠΎ Π³ΠΎΠ΄Π°. ΠΠ΅ΠΎΠ±ΡΡΠ°ΠΉΠ½ΠΎ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΎΠΊΠ°Π·Π°Π»ΠΎΡΡ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΠΎΠ΅ Π½Π°ΠΌΠΈ Π½ΠΎΠ²ΠΎΠ΅ ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΠ΅ Π²Π°ΠΊΡΠΈΠ½, Π³Π΄Π΅ ΡΠΆΠ΅ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠ΅ΠΏΡΠΈΠ΄Ρ ΠΊΠΎΠ½ΡΡΠ³ΠΈΡΠΎΠ²Π°Π»ΠΈΡΡ Ρ ΠΏΠΎΠ»ΠΈΡΠ°Ρ
Π°ΡΠΈΠ΄Π°ΠΌΠΈ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ². Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, Π±ΡΠ»ΠΈ ΠΎΡΠΊΡΡΡΡ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΊ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ Π²Π°ΠΊΡΠΈΠ½ΠΎΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ ΡΠ΅ΡΠΎΠ³ΡΡΠΏΠΏΡ Π. Π ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π³ΠΎΠ΄Ρ ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΠΈ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠΈΠ»ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ Π΄Π»Ρ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΡΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ Π²ΡΠ΅Ρ
ΡΠ΅ΡΠΎΠ³ΡΡΠΏΠΏ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΡΡ
ΠΏΠ½Π΅Π²ΠΌΠΎΠΊΠΎΠΊΠΊΠ°ΠΌΠΈ ΠΈ Π³Π΅ΠΌΠΎΡΠΈΠ»Π°ΠΌΠΈ, ΠΎΠ΄ΠΈΠ½ ΠΈΠ· Π³Π»Π°Π²Π½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π²ΠΈΡΡΠ»Π΅Π½ΡΠ½ΠΎΡΡΠΈ ΡΡΠΈΡ
ΠΌΠΈΠΊΡΠΎΠ±ΠΎΠ² β IgA1 ΠΏΡΠΎΡΠ΅Π°Π·Ρ, ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ ΠΈΠ΄Π΅Π½ΡΠΈΡΠ½ΡΡ Π΄Π»Ρ Π²ΡΠ΅ΠΉ ΡΠΊΠ°Π·Π°Π½Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ. ΠΠ°ΠΏΠ°ΡΠ΅Π½ΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΡΠΏΠΎΡΠΎΠ±Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΡΡΠΎΠΉ Π²Π°ΠΊΡΠΈΠ½Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡ ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΉ ΠΏΡΠΈΠΎΡΠΈΡΠ΅Ρ Π΅Π΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° ΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ
Use of Partially Thermally Coupled Distillation Systems and Heat Pumps for Reducing the Energy Consumption in the Extractive Distillation of an IsobutanolβIsobutyl Acetate Mixture Using Dimethylformamide
Study of antimycotic activity of lyticase
Laboratory studies of lyticase (enzymatic drug) as an antimycotic agent were carried out. The enzyme reduced optical density of Candida albicans test culture, inhibited adhesion of yeast-like fungi on vaginal epitheliocytes, stimulated the formation of germinative tubes, and made Candida albicans more available for phagocytosis. Β© 2009 Springer Science+Business Media, Inc
Study of antimycotic activity of lyticase
Laboratory studies of lyticase (enzymatic drug) as an antimycotic agent were carried out. The enzyme reduced optical density of Candida albicans test culture, inhibited adhesion of yeast-like fungi on vaginal epitheliocytes, stimulated the formation of germinative tubes, and made Candida albicans more available for phagocytosis. Β© 2009 Springer Science+Business Media, Inc
Damaging effects of lyticase on candida albicans and changes in the response of rat alveolar macrophages to the contact with yeast-like fungi
Changes in the cell wall of yeast-like fungi Candida albicans caused by bacterial enzyme lyticase were studied under an electron microscope. The results were compared with the findings on phagocytosis of lyticase-treated Candida albicans by rat alveolar macrophages. It was shown that destruction of the mannan and fibrous outer layers of the cell wall of yeast-like fungi treated with the enzyme led to the release of intracellular organelles and their content. Lyticase treatment reduced the resistance of Candida albicans to intracellular digestion by macrophages contributing to completion of phagocytosis. Β© 2011 Springer Science+Business Media, Inc
Damaging effects of lyticase on candida albicans and changes in the response of rat alveolar macrophages to the contact with yeast-like fungi
Changes in the cell wall of yeast-like fungi Candida albicans caused by bacterial enzyme lyticase were studied under an electron microscope. The results were compared with the findings on phagocytosis of lyticase-treated Candida albicans by rat alveolar macrophages. It was shown that destruction of the mannan and fibrous outer layers of the cell wall of yeast-like fungi treated with the enzyme led to the release of intracellular organelles and their content. Lyticase treatment reduced the resistance of Candida albicans to intracellular digestion by macrophages contributing to completion of phagocytosis. Β© 2011 Springer Science+Business Media, Inc
Application of electrochemical breath test for detection of Helicobacter pylori in screening of Moscow students
The incidence of Helicobacter pylori infection is analyzed by the results of screening of firstand fourth-year students of Moscow Institute of Foreign Affairs using HelicoSense Scientific breath test system. Age-related dynamics of the infection in patients examined for the first time has been traced. The data on infection rates in patients after eradication therapy are presented. Β© 2012 Springer Science+Business Media, Inc
Application of electrochemical breath test for detection of Helicobacter pylori in screening of Moscow students
The incidence of Helicobacter pylori infection is analyzed by the results of screening of firstand fourth-year students of Moscow Institute of Foreign Affairs using HelicoSense Scientific breath test system. Age-related dynamics of the infection in patients examined for the first time has been traced. The data on infection rates in patients after eradication therapy are presented. Β© 2012 Springer Science+Business Media, Inc