Sensitivity analysis: Relationship between lymphopenia and acute brain injury and mortality of patients without cancer or diabetes, HIV, and steroid use.

<p><b>(A)</b> There was not a statistically significant relationship between lymphocyte count and acute brain injury as measured with delirium-free and coma-free days (DCFDs; p = 0.18). DCFDs refer to the number of days patients were alive and free of both delirium and coma in the first 30 days. (<b>B)</b> The hazard ratio between lymphopenia and 30-day mortality was not statistically significant (p = 0.25). The unit of lymphocyte count is 10³/μL blood. DCFDs refer to the number of days patients were alive and free of both delirium and coma in the first 30 days.</p

Baseline characteristics of Vanderbilt BRAIN patients.

<p>Continuous variables presented as median (interquartile range) and categorical variables presented as percent.</p><p>Baseline characteristics of Vanderbilt BRAIN patients.</p

Main analysis: Relationships between lymphopenia and acute brain injury and mortality.

<p><b>(A)</b> There was not a statistically significant relationship between lymphopenia and acute brain injury as measured by delirium-free and coma-free days (DCFDs; p = 0.17). DCFDs refer to the number of days patients were alive and free of both delirium and coma in the first 30 days. The unit of lymphocyte count is 10³/μL blood. (<b>B)</b> Likewise, the hazard ratio between lymphopenia and 30-day mortality was not statistically significant (p = 0.71). The unit of lymphocyte count is 10³/μL blood.</p

Multivariable analyses of factors associated with increased hospital mortality.

<p>Model containing the Delirium/Coma: Area under receiver operating characteristic curve = 0.67 (95% CI, 0.59 to 0.74).</p><p>Model containing the Delirium/Coma- Free Days: Area under receiver operating characteristic curve = 0.75 (95% CI, 0.68–0.81).</p><p>SAPSII - Simplified Acute Physiology Score II; CI – confidence interval.</p

Kaplan–Meier analysis depicting the impact of delirium/coma on hospital mortality.

<p>Kaplan–Meier analysis depicting the impact of delirium/coma on hospital mortality.</p

Demographic and clinical variables of patients according to the presence of acute brain dysfunction.

*<p>For comparisons among patients with and without the diagnosis of acute brain dysfunction.</p><p>SAPS II - Simplified Acute Physiology Score II; SOFA - Sequential Organ Failure Assessment; ICU - intensive care unit; LOS –length of stay; Performance is status is defined according to the Eastern Cooperative Oncology Group (ECOG) scale.</p><p>Results expressed as median (25%–75% interquartile range) and number (%).</p

Study Flow Diagram.

<p>Study Flow Diagram.</p

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