9,848 research outputs found

    Determining the Statistical Significance of Observed Frequencies of Short DNA Motifs in a Genome

    Get PDF
    Until recently over 90 percent of the DNA in the human genome was considered junk DNA, with no known function. However, this non-coding DNA is now known to harbor elements that perform important functions in gene regulation. In particular, there is currently much interest in the search for short DNA motifs collectively known as cis-regulatory elements. Most studies attempt to identify these elements by means of cross-species comparisons. We have approached the problem of finding cis-regulatory elements by searching for conserved DNA motifs within genomes. This requires searching for DNA motifs that are repeated in the genomes either more or less frequently than expected by random chance. However, the usual chi-squared test cannot be used to test for the statistical significance of any observed frequency since overlapping regions of the genome are checked for DNA motif matches. We present here a statistical measure that has been developed to quantify the expectation and variance of the frequency of a given DNA motif in a given target sequence that may contain overlapping regions

    Determining the Statistical Significance of Observed Frequencies of Short DNA Motifs in a Genome

    Get PDF
    Until recently over 90 percent of the DNA in the human genome was considered junk DNA, with no known function. However, this non-coding DNA is now known to harbor elements that perform important functions in gene regulation. In particular, there is currently much interest in the search for short DNA motifs collectively known as cis-regulatory elements. Most studies attempt to identify these elements by means of cross-species comparisons. We have approached the problem of finding cis-regulatory elements by searching for conserved DNA motifs within genomes. This requires searching for DNA motifs that are repeated in the genomes either more or less frequently than expected by random chance. However, the usual chi-squared test cannot be used to test for the statistical significance of any observed frequency since overlapping regions of the genome are checked for DNA motif matches. We present here a statistical measure that has been developed to quantify the expectation and variance of the frequency of a given DNA motif in a given target sequence that may contain overlapping regions

    Evidence for a New Dissipationless Regime in 2D Electronic Transport

    Full text link
    In an ultra-clean 2D electron system (2DES) subjected to crossed millimeterwave (30--150 GHz) and weak (B < 2 kG) magnetic fields, a series of apparently dissipationless states emerges as the system is detuned from cyclotron resonances. Such states are characterized by an exponentially vanishing low-temperature longitudinal resistance and a classical Hall resistance. The activation energies associated with such states exceeds the Landau level spacing by an order of magnitude. Our findings are likely indicative of a collective ground state previously unknown for 2DES.Comment: 4 pages, 2 figure

    Microwave photoresistance of a high-mobility two-dimensional electron gas in a triangular antidot lattice

    Full text link
    The microwave (MW) photoresistance has been measured on a high-mobility two-dimensional electron gas patterned with a shallow triangular antidot lattice, where both the MW-induced resistance oscillations (MIRO) and magnetoplasmon (MP) resonance are observed superposing on sharp commensurate geometrical resonance (GR). Analysis shows that the MIRO, MP, and GR are decoupled from each other in these experiments.Comment: 5 pages, 4 figures, paper accepted by PR

    Initial data for Einstein's equations with superposed gravitational waves

    Get PDF
    A method is presented to construct initial data for Einstein's equations as a superposition of a gravitational wave perturbation on an arbitrary stationary background spacetime. The method combines the conformal thin sandwich formalism with linear gravitational waves, and allows detailed control over characteristics of the superposed gravitational wave like shape, location and propagation direction. It is furthermore fully covariant with respect to spatial coordinate changes and allows for very large amplitude of the gravitational wave.Comment: Version accepted by PRD; added convergence plots, expanded discussion. 9 pages, 9 figure

    An All-Cryogenic THz Transmission Spectrometer

    Get PDF
    This paper describes a THz transmission spectrometer for the spectral range of 2-65 cm^-1 (100 GHz to 2 THz) with a spectral resolution of at least 1.8 cm^-1 (50 GHz) where the source, sample, and detector are all fully contained in a cryogenic environment. Cyclotron emission from a two-dimensional electron gas heated with an electrical current serves as a magnetic field tunable source. The spectrometer is demonstrated at 4.2 K by measuring the resonant cyclotron absorption of a second two dimensional electron gas. Unique aspects of the spectrometer are that 1) an ultra-broadband detector is used and 2) the emitter is run quasi-continuously with a chopping frequency of only 1 Hz. Since optical coupling to room temperature components is not necessary, this technique is compatible with ultra-low temperature (sub 100 mK) operation.Comment: 7 pages, 5 figures. Author affiliation and funding acknowledgements clarifie

    Current Path Properties of the Transport Anisotropy at Filling Factor 9/2

    Full text link
    To establish the presence and orientation of the proposed striped phase in ultra-high mobility 2D electron systems at filling factor 9/2, current path transport properties are determined by varying the separation and allignment of current and voltage contacts. Contacts alligned orthogonal to the proposed intrinsic striped phase produce voltages consistent with current spreading along the stripes; current driven along the proposed stripe direction results in voltages consistent with channeling along the stripes. Direct comparison is made to current spreading/channeling properties of artificially induced 1D charge modulated systems, which indicates the 9/2 direction.Comment: 10 pages, 4 figure
    • …
    corecore