Economic and political fundamentals for the establishment of the cabinet-owned metallurgical complex in Siberia in the 18th century

Economic and political fundamentals for the development of mining and metallurgical production in Siberia in the 18th century are discussed in this paper. The principal type of ownership of large enterprises at that time was serf manufactory, the development of which took place in the conditions of absolutism based on forced labor. Based on a comprehensive set of archive documents, the authors have studied the problem of the transfer under the authority of the Imperial Cabinet of the private Kolyvano-Voskresensk enterprises owned by Demidov, which were established in the 1720s in the south area of Western Siberia. The status change of industrial enterprises is discussed in the context of accidental events (the death of Akinfiy Demidov and the controversy of his heirs) and the consistent processes of development of silver smelting production in the country. The quick development of the metallurgical industry in Russia in the 18th century was caused by a number of domestic and external factors. The Crown extensively attracted private sector capital for the search and development of ore deposits, especially in remote Uralian and Siberian areas. In the 1720s-1740s, the Kolyvano-Voskresensk industrial-territorial complex privately owned by Akinfiy Demidov was established in the south area of Western Siberia. In the middle of the 1740s, the events happened, as a result of which the possessory belonging of the enterprises was changed and these enterprises were transferred under the control and management of the governmental institution – that is, the Imperial Cabinet. Thus, the Kolyvano-Voskresensk plants became the basis of the Cabinet production unit which existed in the 18h-19th centuries.peer-reviewe

Ecological and economic potential and prospects for organic production in the regions of Russia

Purpose: The article assesses the ecological and economic potential of organic production in the regions of Russia and substantiates the prospects for the regions’ production activity. Design: Assessment of the resource potential of the Russian regions in the direction of the development of organic agriculture, the substantiation of the effectiveness of new areas of activity for the Russian agrarian economy. Findings: The increase in agricultural and food production in excess of regulatory needs in order to ensure food security in Russia has led to the expansion of agricultural exports as well as to a change of the agro-industrial complex development vector from import substitution to export-oriented production. Practical implications: Environmental problems of agriculture are identified, mechanisms for their solution are justified. Based on the environmental and economic assessment, the most promising agrarian regions were selected as potential producers of organic products. Originality: The article substantiates ecological, economic and resource potential, shows the potential of the producers of the Russian regions in the production of organic products, the development of organic agriculture and the use of bio-intensive agricultural technologies.peer-reviewe

Economic potential and development prospects of small businesses in rural areas

The article examines the role of small business in the development of rural areas by the example of bakery production. Moreover, it demonstrates the need for the interaction of small bakery businesses with large enterprises of the industry and grain processors. The article reveals the development trends of small bakery production in rural areas. The conditions for the participation of small bakery businesses in rural areas in the development of the production of functional and specialized bread are substantiated. The article proposes the directions and mechanisms of support for small bakery production at the level of rural territories. The development of modern methods of redistribution of bakery production in proportion to the living population, measures of state support for small bakery production and expansion of the range of bread products that contribute to improving the health of the population of Russia, is the theme of this study. The object of the research is the development of small bakery production as a condition for improving the quality of life of the population in rural areas. The subject of the research is production and management relations that ensure the development of small bakery production and its impact on the quality of life of the population in rural areas.peer-reviewe

Long-term management of patients with epilepsy. Organization of a service in the Tyumen Region

Epilepsy is a chronic brain disease that requires a long-term or lifelong follow-up of patients. The factors that influence the outcome of therapy are various; moreover, the key factors of them are the organization of care and the mode of patient follow-up. The necessity of optimizing the specialized health care to this category of patients stems from the poorer quality of life in the patients and their families and from the more frequentdevelopment of mental disorders and drug-resistant forms of the disease during ineffective therapy. These and other issues are considered in this paper with emphasis on the specific area – the south of the Tyumen Region. This underlines the importance of setting up not only highlevel epileptologic centers, but also a whole network that provides access to specialized epileptologic care. It seems today that it is more appropriate to solve problems in the organization of management for epileptic patients at the level of an administrative region, for this state structure has all necessary conditions for rapidly and rationally implementing the most successful developments of specialized care to the population

Organizational and economic transformations towards the greening of agro-industrial production

The increase in the production of agricultural products and food supplies in excess of regulatory needs and the provision of food safety in Russia led to the expansion of the export of agricultural products and the change in the course of the development of the agro-industrial complex from import substitution to export-oriented production. However, the entry to world food markets requires high quality of products from manufacturers and its certification in accordance with world standards. The article presents the organizational and economic transformations towards the greening of agro-industrial production, namely, the use of the resource potential, the involvement of Russian manufacturers in the production of environmentally friendly products and the development of organic agriculture; the mechanisms for solving the set problems are substantiated.peer-reviewe

Economic and mathematical modeling of regional industrial processes

The paper presents a method for the parallel optimization of the structure of sown areas for calculating economic and mathematical models for the traditional and organic-oriented land use systems characterized by the introduction of an additional set of environmental criteria constraints. Based on the proposed methodology, an economic-mathematical model has been calculated and the effectiveness of the functioning of the Altai Foothills zonal agroecocluster has been proved. Considering the full involvement in the agricultural production turnover of land suitable to produce organic products, the level of profitability was 39.7% against 17.3% in case of optimizing the structure of the sown areas in the traditional system of agricultural production.peer-reviewe

Ontogeny of the Human Pancreas

Pancreatic disorders are the most common pathologies in humans worldwide. Detailed information on pancreatic cytoarchitecture, vascularisation, innervation, morphogenesis, and cell differentiation is required for the development of new approaches to the treatment of these diseases. Currently, the majority of studies on pancreas development are performed on experimental animals (mainly rodents). Studies on human pancreatic prenatal development are restricted in number by ethical constraints and some technical difficulties. However, interspecies differences in pancreatic structure and development are considerable. Therefore, data obtained in experiments on animals and cell cultures must be supplemented with information obtained directly from human pancreatic autopsies. In this chapter, we summarise our previous results and the literature data on human pancreatic ontogeny. Special attention has been paid to the endocrine pancreas, which undergoes morphogenetic restructuring during human development. Several forms of structural organisation of the endocrine pancreas (single endocrine cells, small clusters of endocrine cells, mantle, bipolar, and mosaic islets) gradually appear during development. It is important that this restructuring is accompanied by changes in the ratio of pancreatic endocrine cells. The mechanisms of these changes are still unclear. The difficulties in identifying progenitor cells and tracking cell differentiation are the main problems associated with this issue

Ensuring the national security of agriculture in the digital era through the formation of human capital

Purpose: Over the past few years in many literary sources and the media an issue of the digital economy is rapidly gaining popularity due to the qualitative technological changes in society. In current circumstances the qualitative component of labor resources called “human capital” is a priority value. Design/Methodology/Approach: The following research methods have been used in the work: monographic, abstract-logical, sociological, economic-mathematical and calculation-constructive ones. Findings: The solution of the problem of ensuring food security of the population of the region depends on the methods and strategies of applying technologies in domestic and global agriculture, as well as on the correct and effective use of scientific-technical implementations in the industry. Practical implications: Identification of segments in tourism is mainly made based on their geographical, demographical, socio-economic, psychographic, behavior characteristics or their combinations. On the other hand, the authors stress on the fact that there is no universal segmentation approach and therefore, potential tourists can be classified based on other characteristics. Originality/Value: The use of digital technologies in the agricultural industry will increase the efficiency of production activities.peer-reviewe