3 research outputs found
ΠΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°ΡΠΈΡ ΠΏΠΎΡΠΎΠ΄ Π΄ΠΎΠΌΠ°ΡΠ½ΠΈΡ ΡΠ²ΠΈΠ½Π΅ΠΉ c ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠ°ΡΡΠΈΡΠ΅Π½Π½ΠΎΠ³ΠΎ Π±ΠΈΠΎΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° SNP
Using the methods of bioinformatics, the analysis of data on sequencing of the genomes of individuals of the species Sus scrofa domesticus, which are located in the Sequence Read Archive (NCBI-SRA) database, was carried out. Genotypes were determined in silico for five breeds of domestic pigs β Duroc, Landrace, Pietrain, Large White and Yorkshire using an algorithm developed in the Python programming language. Based on a two-stage bioinformatics analysis, a wide range of SNPs with a high potential for differentiation was identified. The results obtained will be used to create express methods for determining the purity of pigs of these breeds. Extended bioinformatics analysis, which included genotyping by 7451 SNPs for 248 Sus scrofa domesticus genomes, revealed a total of 393 SNPs for all breeds for which there is a significant difference in the frequency of alternative alleles in Duroc, Landrace, Pietrain, Large White and Yorkshire pig breeds. Clusters within chromosomes are indicated, in which the density of SNPs with a high differentiating potential is the highest. For Duroc pigs, we identified 184 SNPs with differentiating potential, 24 of which showed a high differentiating potential, for Landrace pigs β 52 SNPs and 7, for Pietrain pigs β 39 and 9, for Large White pigs β 104 and 22, for Yorkshire pigs β 14 and 5, respectively.Π‘ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π±ΠΈΠΎΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΊΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Π΄Π°Π½Π½ΡΡ
ΠΏΠΎ ΡΠ΅ΠΊΠ²Π΅Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π³Π΅Π½ΠΎΠΌΠΎΠ² ΠΎΡΠΎΠ±Π΅ΠΉ Π²ΠΈΠ΄Π° Sus scrofa domesticus, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Ρ Π² Π±Π°Π·Π΅ Sequence Read Archive (NCBI-SRA). ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ in silico Π³Π΅Π½ΠΎΡΠΈΠΏΡ Π΄Π»Ρ ΠΏΡΡΠΈ ΠΏΠΎΡΠΎΠ΄ Π΄ΠΎΠΌΠ°ΡΠ½ΠΈΡ
ΡΠ²ΠΈΠ½Π΅ΠΉ β Π΄ΡΡΠΎΠΊ, Π»Π°Π½Π΄ΡΠ°Ρ, ΠΏΡΠ΅ΡΡΠ΅Π½, ΠΊΡΡΠΏΠ½Π°Ρ Π±Π΅Π»Π°Ρ ΠΈ ΠΉΠΎΡΠΊΡΠΈΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π°Π»Π³ΠΎΡΠΈΡΠΌΠ°, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΠΎΠ³ΠΎ Π½Π° ΡΠ·ΡΠΊΠ΅ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Python. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ Π΄Π²ΡΡ
ΡΡΠ°Π΄ΠΈΠΉΠ½ΠΎΠ³ΠΎ Π±ΠΈΠΎΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ ΡΠΈΡΠΎΠΊΠΈΠΉ ΠΏΠ΅ΡΠ΅ΡΠ΅Π½Ρ SNP c Π²ΡΡΠΎΠΊΠΈΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ Π΄Π»Ρ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π±ΡΠ΄ΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΠΏΡΠΈ ΡΠΎΠ·Π΄Π°Π½ΠΈΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡ-ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠΈΡΡΠΎΠΏΠΎΡΠΎΠ΄Π½ΠΎΡΡΠΈ ΡΠ²ΠΈΠ½Π΅ΠΉ Π΄Π°Π½Π½ΡΡ
ΠΏΠΎΡΠΎΠ΄. Π Π°ΡΡΠΈ ΡΠ΅Π½Π½ΡΠΉ Π±ΠΈΠΎΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ·, ΠΊΠΎΡΠΎΡΡΠΉ Π²ΠΊΠ»ΡΡΠ°Π» Π² ΡΠ΅Π±Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π³Π΅Π½ΠΎΡΠΈΠΏΠ° ΠΏΠΎ 7451 SNP Π΄Π»Ρ 248 Π³Π΅Π½ΠΎΠΌΠΎΠ² Sus scrofa domesticus, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ» Π²ΡΡΠ²ΠΈΡΡ ΡΡΠΌΠΌΠ°ΡΠ½ΠΎ 393 SNP Π΄Π»Ρ Π²ΡΠ΅Ρ
ΠΏΠΎΡΠΎΠ΄, Π΄Π»Ρ ΠΊΠΎΡΠΎΡΡΡ
ΠΈΠΌΠ΅Π΅ΡΡΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ ΡΠ°Π·Π½ΠΈΡΠ° Π² ΡΠ°ΡΡΠΎΡΠ΅ Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ²Π½ΡΡ
Π°Π»Π»Π΅Π»Π΅ΠΉ Ρ ΠΏΠΎΡΠΎΠ΄ ΡΠ²ΠΈΠ½Π΅ΠΉ Π΄ΡΡΠΎΠΊ, Π»Π°Π½Π΄ΡΠ°Ρ, ΠΏΡΠ΅ΡΡΠ΅Π½, ΠΊΡΡΠΏΠ½Π°Ρ Π±Π΅Π»Π°Ρ ΠΈ ΠΉΠΎΡΠΊΡΠΈΡ. ΠΠ±ΠΎΠ·Π½Π°ΡΠ΅Π½Ρ ΠΊΠ»Π°ΡΡΠ΅ΡΡ Π² ΠΏΡΠ΅Π΄Π΅Π»Π°Ρ
Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌ, Π² ΠΊΠΎΡΠΎΡΡΡ
ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡ SNP Ρ Π²ΡΡΠΎΠΊΠΈΠΌ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΡΡΡΠΈΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠ°. ΠΠ»Ρ ΡΠ²ΠΈΠ½Π΅ΠΉ ΠΏΠΎΡΠΎΠ΄Ρ Π΄ΡΡΠΎΠΊ Π½Π°ΠΌΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ 184 SNP, ΠΈΠΌΠ΅ΡΡΠΈΠ΅ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΡΡΡΠΈΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π», Π΄Π»Ρ 24 ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ
ΠΏΠΎΠΊΠ°Π·Π°Π½ Π²ΡΡΠΎΠΊΠΈΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΡΡΡΠΈΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π», Π΄Π»Ρ ΡΠ²ΠΈΠ½Π΅ΠΉ ΠΏΠΎΡΠΎΠ΄Ρ Π»Π°Π½Π΄ΡΠ°Ρ β 52 SNP ΠΈ 7, Π΄Π»Ρ ΡΠ²ΠΈΠ½Π΅ΠΉ ΠΏΠΎΡΠΎΠ΄Ρ ΠΏΡΠ΅ΡΡΠ΅Π½ β 39 ΠΈ 9, Π΄Π»Ρ ΡΠ²ΠΈΠ½Π΅ΠΉ ΠΏΠΎΡΠΎΠ΄Ρ ΠΊΡΡΠΏΠ½Π°Ρ Π±Π΅Π»Π°Ρ β 104 ΠΈ 22, Π΄Π»Ρ ΡΠ²ΠΈΠ½Π΅ΠΉ ΠΏΠΎΡΠΎΠ΄Ρ ΠΉΠΎΡΠΊΡΠΈΡ β 14 ΠΈ 5 ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ
ΠΠ½Π°Π»ΠΈΠ· ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½ΠΎΠ² KDM3A ΠΈ DBX2 Π΄Π»Ρ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ ΡΠ²ΠΈΠ½Π΅ΠΉ ΠΏΠΎΡΠΎΠ΄Ρ Π΄ΡΡΠΎΠΊ Π²ΠΈΠ΄Π° Sus scrofa domesticus
Genotyping of individuals of 7 commercial breeds of domestic pigs was carried out: Duroc, Landrace, Belarusian Large White, Belarusian Black-and-White, Belarusian meat, Pietrain and Yorkshire for the KDM3A and DBX2 genes. The high breed-specific potential of polymorphic loci g.58335217A>G (KDM3A gene) and g.75953650G>T (DBX2 gene) for differentiation of Duroc pigs of the species Sus scrofa domesticus was confirmed. A test model for differentiation of Duroc individuals by bioinformatic assessment of a total contribution of two SNPs of the KDM3A and DBX2 genes was proposed. This test model has no analogues in the world, and its estimation accuracy and specificity are 98.76 and 99.68 %, respectively. Using PCR-RFLP, a fast and simple approach has been developed to differentiate the Duroc breed based on the proposed test model.Β ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π³Π΅Π½ΠΎΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡΠΎΠ±Π΅ΠΉ 7 ΠΊΠΎΠΌΠΌΠ΅ΡΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΡΠΎΠ΄ Π΄ΠΎΠΌΠ°ΡΠ½ΠΈΡ
ΡΠ²ΠΈΠ½Π΅ΠΉ: Π΄ΡΡΠΎΠΊ, Π»Π°Π½Π΄ΡΠ°Ρ, Π±Π΅Π»ΠΎΡΡΡΡΠΊΠ°Ρ ΠΊΡΡΠΏΠ½Π°Ρ Π±Π΅Π»Π°Ρ, Π±Π΅Π»ΠΎΡΡΡΡΠΊΠ°Ρ ΡΠ΅ΡΠ½ΠΎ-ΠΏΠ΅ΡΡΡΠ°Ρ, Π±Π΅Π»ΠΎΡΡΡΡΠΊΠ°Ρ ΠΌΡΡΠ½Π°Ρ, ΠΏΡΠ΅ΡΡΠ΅Π½ ΠΈ ΠΉΠΎΡΠΊΡΠΈΡ ΠΏΠΎ Π³Π΅Π½Π°ΠΌ KDM3A ΠΈ DBX2. ΠΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ Π²ΡΡΠΎΠΊΠΈΠΉ ΠΏΠΎΡΠΎΠ΄ΠΎΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΡΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π» ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΡΡ
Π»ΠΎΠΊΡΡΠΎΠ² g.58335217A>G (Π³Π΅Π½ KDM3A) ΠΈ g.75953650G>T (Π³Π΅Π½ DBX2) Π΄Π»Ρ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ ΡΠ²ΠΈΠ½Π΅ΠΉ ΠΏΠΎΡΠΎΠ΄Ρ Π΄ΡΡΠΎΠΊ Π²ΠΈΠ΄Π° Sus scrofa domesticus. ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π° ΡΠ΅ΡΡ-ΠΌΠΎΠ΄Π΅Π»Ρ Π΄Π»Ρ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ ΠΎΡΠΎΠ±Π΅ΠΉ ΠΏΠΎΡΠΎΠ΄Ρ Π΄ΡΡΠΎΠΊ ΠΏΠΎ Π±ΠΈΠΎΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΠΎΠ²ΠΎΠΊΡΠΏΠ½ΠΎΠ³ΠΎ Π²ΠΊΠ»Π°Π΄Π° Π΄Π²ΡΡ
SNP Π³Π΅Π½ΠΎΠ² KDM3A ΠΈ DBX2. ΠΠ°Π½Π½Π°Ρ ΡΠ΅ΡΡ-ΠΌΠΎΠ΄Π΅Π»Ρ Π½Π΅ ΠΈΠΌΠ΅Π΅Ρ ΠΌΠΈΡΠΎΠ²ΡΡ
Π°Π½Π°Π»ΠΎΠ³ΠΎΠ², Π° ΡΠΎΡΠ½ΠΎΡΡΡ Π΅Π΅ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΈ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΠΎΡΡΠ°Π²Π»ΡΠ΅Ρ 98,76 ΠΈ 99,68 % ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ. Π‘ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΠ¦Π -ΠΠΠ Π€ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ Π±ΡΡΡΡΡΠΉ ΠΈ ΠΏΡΠΎΡΡΠΎΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ Π΄Π»Ρ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ ΠΏΠΎΡΠΎΠ΄Ρ Π΄ΡΡΠΎΠΊ Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΡ-ΠΌΠΎΠ΄Π΅Π»ΠΈ.
ΠΠΈΠΎΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· Π³Π΅Π½ΠΎΠΌΠΎΠ² ΠΊΠΎΠΌΠΌΠ΅ΡΡΠ΅ΡΠΊΠΈΡ ΠΏΠΎΡΠΎΠ΄ Π΄ΠΎΠΌΠ°ΡΠ½ΠΈΡ ΡΠ²ΠΈΠ½Π΅ΠΉ Π΄Π»Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈ- ΠΊΠ°ΡΠΈΠΈ ΠΏΠΎΡΠΎΠ΄ΠΎΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΡΡ SNP
Determining the purebredity of farm animals in a breeding system is of key importance for the entire livestock industry. Purebred breeding of plant breeds is designed to ensure the production of high-value improving breeding material for commercial livestock breeding. Determination of purebredity of pigs can be carried out using single nucleotide polymorphisms (SNP). The multiplexing technology today has reached a level that makes it possible to characterize tens and hundreds of thousands of polymorphic variants simultaneously for hundreds of animals in one run of the device. For the first time, using bioinformatics methods, an analysis of genome-wide projects was carried out for 264 individuals of the species Sus scrofa located in the Sequence Read Archive (NCBI-SRA). The in silico genotype was determined for 692 SNPs, of which 59 SNPs showed a significant potential for differentiation of four commercial breeds: large white (the most significant SNPs are Chr. 6: g.85845403T> G and Chr.16: g.74053569T> C), duroc (Chr. 4: g.55661608A> G, Chr. 14: g.107689091T> C and Chr. 14: g.107939105T> C), landrace (Chr. 5: g.99925204A> G, Chr. 18: g .40100481A> G and Chr. 18: g.7664624A> G) and pietrain (Chr. 13: g.136017764T> C and Chr.17: g.47595840A> G). For breeds of duroc and pietrain pigs, the accuracy of differentiation was at least 99%, for breeds of large white and landrace pigs - over 80%, however, the sensitivity indicator characterizing the percentage of false positive results of classification was slightly over 65%. Creation of models for molecularand-genetic studies of these breeds will allow for a genetic examination of their purebredity, which will contribute to an increase in their breeding value and preservation of the national gene pool.ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΈΡΡΠΎΠΏΠΎΡΠΎΠ΄Π½ΠΎΡΡΠΈ ΡΠ΅Π»ΡΡΠΊΠΎΡ
ΠΎΠ·ΡΠΉΡΡΠ²Π΅Π½Π½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π² ΡΠ΅Π»Π΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠ΅ ΠΈΠΌΠ΅Π΅Ρ ΠΊΠ»ΡΡΠ΅Π²ΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ Π΄Π»Ρ Π²ΡΠ΅ΠΉ ΠΎΡΡΠ°ΡΠ»ΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΠΎΠ²ΠΎΠ΄ΡΡΠ²Π°. Π§ΠΈΡΡΠΎΠΏΠΎΡΠΎΠ΄Π½ΠΎΠ΅ ΡΠ°Π·Π²Π΅Π΄Π΅Π½ΠΈΠ΅ Π·Π°Π²ΠΎΠ΄ΡΠΊΠΈΡ
ΠΏΠΎΡΠΎΠ΄ ΠΏΡΠΈΠ·Π²Π°Π½ΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²ΠΎ Π²ΡΡΠΎΠΊΠΎΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΠ»ΡΡΡΠ°ΡΡΠ΅Π³ΠΎ ΠΏΠ»Π΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° Π΄Π»Ρ ΡΠΎΠ²Π°ΡΠ½ΠΎΠ³ΠΎ ΠΆΠΈΠ²ΠΎΡΠ½ΠΎΠ²ΠΎΠ΄ΡΡΠ²Π°. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΈΡΡΠΎΠΏΠΎΡΠΎΠ΄Π½ΠΎΡΡΠΈ ΡΠ²ΠΈΠ½Π΅ΠΉ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΎΠ΄Π½ΠΎΠ½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΡΡ
ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² (SNP). Π’Π΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΌΡΠ»ΡΡΠΈΠΏΠ»Π΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ΅Π³ΠΎΠ΄Π½Ρ Π΄ΠΎΡΡΠΈΠ³Π»Π° ΡΡΠΎΠ²Π½Ρ, ΠΊΠΎΡΠΎΡΡΠΉ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π·Π° ΠΎΠ΄ΠΈΠ½ Π·Π°ΠΏΡΡΠΊ ΠΏΡΠΈΠ±ΠΎΡΠ° ΠΎΡ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°ΡΡ Π΄Π΅ΡΡΡΠΊΠΈ ΠΈ ΡΠΎΡΠ½ΠΈ ΡΡΡΡΡ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΡΡ
Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² ΠΎΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎ Π΄Π»Ρ ΡΠΎΡΠ΅Π½ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
. ΠΠΏΠ΅ΡΠ²ΡΠ΅ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π±ΠΈΠΎΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΊΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΏΠΎΠ»Π½ΠΎΠ³Π΅Π½ΠΎΠΌΠ½ΡΡ
ΠΏΡΠΎΠ΅ΠΊΡΠΎΠ² Π΄Π»Ρ 264 ΠΎΡΠΎΠ±Π΅ΠΉ Π²ΠΈΠ΄Π° Sus scrofa, ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΡΡ
Π² Π±Π°Π·Π΅ Sequence Read Archive (NCBI-SRA). ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ in silico Π³Π΅Π½ΠΎΡΠΈΠΏ Π΄Π»Ρ 692 SNP, ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ
Π΄Π»Ρ 59 SNP ΠΏΠΎΠΊΠ°Π·Π°Π½ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π» Π΄Π»Ρ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ ΡΠ΅ΡΡΡΠ΅Ρ
ΠΊΠΎΠΌΠΌΠ΅ΡΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΡΠΎΠ΄: ΠΊΡΡΠΏΠ½Π°Ρ Π±Π΅Π»Π°Ρ (Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π·Π½Π°ΡΠΈΠΌΡΠ΅ SNP β Chr.6:g.85845403T>G ΠΈ Chr.16:g.74053569T>C), Π΄ΡΡΠΎΠΊ (Chr.4:g.55661608A>G, Chr.14:g.107689091T>C ΠΈ Chr.14:g.107939105T>C), Π»Π°Π½Π΄ΡΠ°Ρ (Chr.5:g.99925204A>G, Chr.18:g.40100481A>G ΠΈ Chr.18:g.7664624A>G) ΠΈ ΠΏΡΠ΅ΡΡΠ΅Π½ (Chr.13:g.136017764T>C ΠΈ Chr.17:g.47595840A>G). ΠΠ»Ρ ΠΏΠΎΡΠΎΠ΄ ΡΠ²ΠΈΠ½Π΅ΠΉ Π΄ΡΡΠΎΠΊ ΠΈ ΠΏΡΠ΅ΡΡΠ΅Π½ ΡΠΎΡΠ½ΠΎΡΡΡ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°ΡΠΈΠΈ Π±ΡΠ»Π° Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ 99 %, Π΄Π»Ρ ΠΏΠΎΡΠΎΠ΄ ΡΠ²ΠΈΠ½Π΅ΠΉ ΠΊΡΡΠΏΠ½Π°Ρ Π±Π΅Π»Π°Ρ ΠΈ Π»Π°Π½Π΄ΡΠ°Ρ β Π±ΠΎΠ»Π΅Π΅ 80 %, ΠΎΠ΄Π½Π°ΠΊΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΠΉ ΠΏΡΠΎΡΠ΅Π½Ρ Π»ΠΎΠΆΠ½ΠΎΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ, Π±ΡΠ» Π½Π΅ΠΌΠ½ΠΎΠ³ΠΈΠΌ Π±ΠΎΠ»Π΅Π΅ 65 %. Π‘ΠΎΠ·Π΄Π°Π½ΠΈΠ΅ ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ Π΄Π»Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π΄Π°Π½Π½ΡΡ
ΠΏΠΎΡΠΎΠ΄ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΡΡ ΡΠΊΡΠΏΠ΅ΡΡΠΈΠ·Ρ ΠΈΡ
ΡΠΈΡΡΠΎΠΏΠΎΡΠΎΠ΄Π½ΠΎΡΡΠΈ, ΡΡΠΎ Π±ΡΠ΄Π΅Ρ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°ΡΡ Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π½ΠΈΡ ΠΈΡ
ΠΏΠ»Π΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΡΠ΅Π½Π½ΠΎΡΡΠΈ ΠΈ ΡΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ Π½Π°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π³Π΅Π½ΠΎΡΠΎΠ½Π΄Π°