Dislocation structure and deformation hardening alloy fcc single crystals at the mesolevel

The article presents the evaluation results of impacts of various strengthening mechanisms to flow stress. Such evaluations were made on the basis of the measured parameters of the dislocation substructure formed in monocrystals of [001]-Ni3Fe alloy deformed by compression within the stage II. It was found that the main impact to deformation resistance in the alloys with net substructure is made by the mechanism of dislocation impediment, which is caused by contact interaction between moving dislocations and forest dislocations

Dislocation structure and deformation hardening alloy fcc single crystals at the mesolevel

The article presents the evaluation results of impacts of various strengthening mechanisms to flow stress. Such evaluations were made on the basis of the measured parameters of the dislocation substructure formed in monocrystals of [001]-Ni3Fe alloy deformed by compression within the stage II. It was found that the main impact to deformation resistance in the alloys with net substructure is made by the mechanism of dislocation impediment, which is caused by contact interaction between moving dislocations and forest dislocations

A new design for a green calcium indicator with a smaller size and a reduced number of calcium-binding sites

Genetically encoded calcium indicators (GECIs) are mainly represented by two- or one-fluorophore-based sensors. One type of two-fluorophore-based sensor, carrying Opsanus troponin C (TnC) as the Ca2+-binding moiety, has two binding sites for calcium ions, providing a linear response to calcium ions. One-fluorophore-based sensors have four Ca2+-binding sites but are better suited for in vivo experiments. Herein, we describe a novel design for a one-fluorophore-based GECI with two Ca2+-binding sites. The engineered sensor, called NTnC, uses TnC as the Ca2+-binding moiety, inserted in the mNeonGreen fluorescent protein. Monomeric NTnC has higher brightness and pH-stability in vitro compared with the standard GECI GCaMP6s. In addition, NTnC shows an inverted fluorescence response to Ca2+. Using NTnC, we have visualized Ca2+ dynamics during spontaneous activity of neuronal cultures as confirmed by control NTnC and its mutant, in which the affinity to Ca2+ is eliminated. Using whole-cell patch clamp, we have demonstrated that NTnC dynamics in neurons are similar to those of GCaMP6s and allow robust detection of single action potentials. Finally, we have used NTnC to visualize Ca2+ neuronal activity in vivo in the V1 cortical area in awake and freely moving mice using two-photon microscopy or an nVista miniaturized microscope

Effect of Annealing, Stoichiometry, and Surface on Magnetism of (Pr,Dy)FeCoB Microparticles Ensemble

Magnetic properties of powder (Pr,Dy)FeCoB ferrimagnetic alloys and effects of annealing, surface states were analyzed. X-ray photoelectron spectroscopy and Mössbauer spectra of powders indicate the effect of surface states on phase composition and magnetic properties of the studied powder, if particles average size is smaller than 10 μm. Effect of stoichiometry on magnetic anisotropy was found. Thermal stability of anisotropy field was proved by replacement of Fe atoms with Co atoms

North Caucasian Federal District: Conditions and Strategic Reference Points of Development

The authors have carried out the analysis of the North Caucasian Federal District economy in a number of the directions: a general economic situation in the region, investment activity and investment appeal, the diagnostics of the budget stability and budget independence has been performed. They draw the conclusion that the economy of the district has a pronounced non-productive nature, its developed structure and disproportions interfere with forming the stable results and growth of the citizens’ welfare. There are no institutional conditions for the development, a lot of problems with uncoordinated migration flows and logistic disproportions in the region. In order to solve the mentioned problems the concept and the district’s development strategic reference points are offered in the article. One of them is the organization and enhancement of regional clusters. Besides, the forward monotowns dynamics, forming the cross-industry balance, increase in the capacity of the macroregion as a transport (transit) corridor and solving the problems of logistic disproportions through updating and creating the mainstream infrastructure, as well as implementation of a funding mechanism for infrastructure projects are important