PECULIARITIES OF PURINE METABOLISM AND LIPID PEROXIDATION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Aim. To study purine metabolism and lipid peroxidation in patients with acute myocardial infarction with ST segment elevation (STEMI) in dependence on severity of acute heart failure (AHF). To evaluate effects of thrombolytic therapy on purine metabolism and lipid peroxidation.Material and methods. 91 patients (age 60,8±1,2 y.o.) with STEMI and AHF (Killip 1-3) was included into the study. Patients were randomized into 3 groups in dependence of AHF severity. Markers of purine metabolism (activity of 5’- nucleotidase, xantineoxidase and uric acid level) and lipid peroxidation (superoxide dismutase and catalase activity, superoxide-anione radical level) were evaluated.Results. Purine metabolism activity increases, antioxidant and prooxidant balance disturbs at the condition of energy deficiency. AHF progression leads to increase in xanthine oxidize activity, urinary acid level and lungs edematization. Thrombolytic therapy increases antioxidant activity (response on reperfusion), but does not lead to purine metabolism stabilization.Conclusion. Thus, severity of heart failure in patients with STEMI correlates with disorders of purine and lipid metabolism. Thrombolytic therapy leads to rising in antioxidant protection, but does not lead to stabilisation of purine metabolism

Filipino migrant workers’ leisure and subjective quality of life in Macao

Utilizing 14 semi-structured interviews in a non-western context, this exploratory study examines how Filipino migrant workers’ leisure satisfaction and QoL are intertwined in Macao, China. The study reveals that Filipino migrant workers regard “family and friends”, and a sense of community as central to their QoL. Regarding leisure, the Filipino migrant workers experienced a lack of time-off and long working hours (structural leisure constraints) whilst living without their families in the Philippines (interpersonal leisure constraints). In addition, the Filipino migrant workers noted that few leisure options were available to them, and given commercial options dominate in Macao, the perceived cost of leisure participation clashes with the Filipino migrant workers responsibility to send remittances home. It is recommended that authorities and employers explore the importance of subjective QoL indicators such as sense of community that emerge from marginalized social groups, such as migrant workers, into their measurement systems and policy deliberations, to create a livable and sustainable community for all. Our study enriches the extant research by broadening the research location to focus on “voices” from low income migrants in a non-western context