Динамика содержания тяжелых металлов в сырье для получения сердечных гликозидов на примере CONVALLARIA MAJALIS L

Для подтверждения нашей гипотезы о связи географии онкологических заболеваний с содержанием на территориях тяжелых металлов, мы начали изучать их содержание в лекарственных растениях, в частности, в CONVALLARIA MAJALIS L

Динамика содержания тяжелых металлов в сырье для получения сердечных гликозидов на примере CONVALLARIA MAJALIS L

Для подтверждения нашей гипотезы о связи географии онкологических заболеваний с содержанием на территориях тяжелых металлов, мы начали изучать их содержание в лекарственных растениях, в частности, в CONVALLARIA MAJALIS L

Educational research networks principles of organization

Relevance. Modern society has global transformations; as a result, the level characteristics of its system development are changing, new opportunities and new situations to implement a self-organizing system to solve problems of self-government appear. Thus, there is the need to organize the multiplicity of interactions in the new environment, including education. The success of the development mechanisms, organizing innovative activities in the educational systems of different levels is largely determined by the active development of interaction network forms and interaction effective management. The article is devoted to development of theoretical ideas about the processes of network interaction in education to justify and describe the principles of modern scientific-educational network on the basis of system-synergetic approach. A leading approach to study this problem can be considered as system-synergetic which allows studying network interaction within the scientific and educational network as a holistic entity consisting of interrelated elements, structured and complex. The results of the study showed that described principles of effective networking and the conditions of scientific and educational networks development allow you to combine and re-combine the accumulated actors of this knowledge and practical experience interaction, turning them into the means of its innovative activities. The article can be useful to heads of educational institutions of different levels, as well as researchers of innovative processes development problems in education. © 2018 Authors

Stable multiple-charged localized optical vortices in cubic-quintic nonlinear media

The stability of two-dimensional bright vortex solitons in a media with focusing cubic and defocusing quintic nonlinearities is investigated analytically and numerically. It is proved that above some critical beam powers not only one- and two-charged but also multiple-charged stable vortex solitons do exist. A vortex soliton occurs robust with respect to symmetry-breaking modulational instability in the self-defocusing regime provided that its radial profile becomes flattened, so that a self-trapped wave beam gets a pronounced surface. It is demonstrated that the dynamics of a slightly perturbed stable vortex soliton resembles an oscillation of a liquid stream having a surface tension. Using the idea of sustaining effective surface tension for spatial vortex soliton in a media with competing nonlinearities the explanation of a suppression of the modulational instability is proposed.Comment: 4 pages, 3 figures. Submitted to Journal of Optics A. The proceedings of the workshop NATO ARW, Kiev 2003 Singular Optics 200

CYTOMETRIC ANALYSIS OF THE SPECTRUM SUBPOPULATION OF T LYMPHOCYTES IN THE EARLY FORMS OF CHRONIC BRAIN ISCHEMIA VETERANS OF MODERN WARS

Formation of the earliest forms of chronic brain ischemia veterans of modern wars accompanied by an increase in the systemic circulation of the population of T lymphocytes and monocytes, reflecting the activation of central mechanisms lymphopoiesis. In step vascular encephalopathy is an increase in circulating pool of T lymphocytes expressing the activation markers early positive reflecting readiness cells to IL-2 dependent proliferation. When progessirovanii chronic brain ischemia decreased levels of circulating T-regulatory cells, which may reflect a violation of self-tolerance in relation to brain antigens

Cooperation between Russia and Kazakhstan as a Vector of Eurasian Integration

The study analyzes the areas of cooperation between Russia and Kazakhstan within the framework of Eurasian integration.Aim. To identify the presence of factors contributing to the strengthening of relations between Russia and Kazakhstan at the present stage and obstacles hindering the deepening of integration processes.Tasks. To analyze the current state of cooperation between the two countries within the framework of the Eurasian Union, to identify obstacles to deepening integration processes, to show forecast scenarios of interaction between Russia and Kazakhstan. To analyze how these scenarios will affect the relationship between the two countries, and what consequences will be if each of them is implemented.Methods. The article uses general scientific methods of analysis and synthesis, a systematic approach, as well as an empirical method of expert evaluation.Results. The study showed that there are strong relations between the two countries in the economic sphere within the framework of the EAEU. Russia is the main trading partner of Kazakhstan. Projects related to the Caspian Sea are being developed and look very promising. Joint military exercises and supplies of Russian weapons are of great interest to Kazakhstan. Russia acts as a guarantor of Kazakhstan’s security in the region and its main partner in the Eurasian space. The Collective Security Treaty Organization also plays an important role in the relations between the two countries, which proved its effectiveness in the January 2022 events, contributing to the resolution of the political crisis and preventing extremist actions of armed terrorist groups. At the same time, the role of Kazakhstan as its closest neighbor and ally is also important for Russia, especially in the context of escalating international tensions.Conclusions. Both Russia and Kazakhstan are interested in further cooperation in the economic, military and cultural spheres. At the same time, the further deepening of integration processes is hindered by the absence of large joint investment projects and the multi-vector nature of Kazakhstan’s foreign policy. In the context of the information war of the West against Russia and the increasing international tension, it is extremely important to deepen cooperation between the two countries

Formation of a cluster integration system of educational institutions within the region

The relevance of the investigated issue is caused by the need to explore new approaches to the development of integration processes in the field of education which are of great interest for the development of an environment conducive to the creation and the active use of innovations in the education system. The aim of this study is the development of organizational and pedagogical bases for the formation of a cluster integration system of educational institutions within the regional educational space. The basic guideline of the implemented scientific study is the system approach, which provides an integrated study of the cluster system of educational institutions as a highly organized and orderly object comprised of interrelated elements. This article presents organizational and pedagogical bases for the formation of a cluster integration system of educational institutions, which will allow adapting the internal processes of educational entities (participants in the interaction) to regional conditions and adapting particular features of cluster participants to external conditions and developments in the market-based educational environment. © 2016 Davydova et al

Immune changes at the injured sites in oxazolone-induced ulcerous colitis: Influence of ozone therapy

Impaired immunoregulation and development of autoimmune response to antigens of own intestinal microbiota and inflammation-altered antigens of colonic cells represent the key links in pathogenesis of inflammatory bowel diseases. Multimodal biological effects of ozone presunme the usage of local and systemic ozone therapy in complex treatment of many inflammatory diseases of the gastrointestinal tract. The aim of our work was to study effects of intraperitoneal and rectal ozone therapy upon immune parameters of the lesion focus in oxazolone-induced ulcerative colitis in the course of time. The study was carried out on 64 adult male inbred Wistar rats weighing 240±20 g. Experimental ulcerative colitis was produced by oxazolone treatment (4-ethoxymethylene-2-phenyl-2-oxazolin-5-one) (SigmaAldrich, USA). The ozone-oxygen mixture was injected intraperitoneally or rectally at a concentration of 1.0-1.2 mg/l, once a day, in a volume of 10 ml, at the 6-day course. The results of experiments were recorded on the days +2, +4 and +6. The concentrations of IL-17 and IL-23 was determined in a homogenate of intestinal tissues (Bender Medsystems, Austria) using a Personal LAB analyzer; expression of CD4 and FoxP3 on intestinal lymphocytes was determined by immunohistochemistry technique (ElisaKit, China). The observed tissue damage of large intestine showed an increase from day 2 to day 6 of oxazolone-induced ulcerative colitis. The total number of lymphocytes significantly increased upon development of experimental colitis, with parallel decrease in the number of CD4+ lymphocytes and FoxP3-positive T lymphocytes. IL-17 and IL-23 concentrations in the tissues increased with the severity of inflammatory changes in the lesion focus. Intraperitoneal ozone administration was associated with significant reduction of lymphocyte contents in the damaged tissues on the 6th day, whereas the numbers of CD4+ and FoxP3 positive T lymphocytes normalized by the 6th day. The levels of IL-17 and IL-23 increased from day 2 to day 6, with a lower IL-23 values on day 6 as compared with non-treated animals. Rectal administration of ACS led to the normalization of FoxP3 cells on the 6th day to the values of intact animals. The levels of proinflammatory cytokines (IL-17 and IL-23) significantly decreased on the 6th day as compared to the group of animals without treatment, which could be due to anti-inflammatory properties of ozone

Loimologically significant pinniped helminths in Chukotka

The purpose of the research is study of pinniped helminth fauna in Chukotka, and the analysis of the fish of the main commercial families infected with pathogens of helminthozoonoses based on modern literature.Materials and methods. The helminths were collected in autumn of 2019 from pinnipeds caught in the Mechigmenskaya Guba of the Bering Sea in the Chukotka Autonomous Okrug by the method of partial helminthological dissection per Skryabin (gastrointestinal tract). Samples were examined from 6 walruses and 26 seals (13 spotted seals and 13 ringed seals). The helminths found were fixed in 70% alcohol. The helminth species were identified at the Department of Parasitology and Veterinary and Sanitary Examination of the MVA named after K. I. Skryabin using reference literature.Results and discussion. All pinnipeds were infected with nematodes of the family Anisakidae. Mature Pseudoterranova desipiens were found in the walrus (Infection Prevalence = 16.7% with Infection Intensity = 3 specimens/animal), mature Ps. desipiens, as well as Contracoecum osculatum and Anisakis simplex larvae (IP = 30.8% with II from 5 to 57 specimens) were found in the spotted seal, and Ps. desipiens larvae and mature Ps. desipiens were found in the ringed seal (IP = 15.4% with II from 1 to 4 specimens). Thus, only Ps. desipiens were represented by mature stages (females and males), and two other species of anisakids, C. osculatum and A. simplex, were found in the seals in the larval stage

Immune phenotype of tissues from exudative lesions of Reinke’s space

Non-inflammatory exudative lesions of Reinke’ pos space present the most common cause of phonation disorders in representatives of vocal professions. The leading role in pathogenesis of this disorder is given to the nearly complete absence of lymphatic drainage of Reinke space and local deposition of tissue fluid. The mechanisms of its progression are of particular importance when determining the condition of mucosaassociated laryngeal tissue. The aim of our work was to evaluate the parameters of immunohistochemical lymphocyte typing in exudative lesions from the Reinke’s space. Materials and methods: The main group consisted of 40 patients, at the mean age of 43.2±2.1 years, exhibiting tumor-like exudative lesions of Reinke’s space. The biopsy material was taken from the vocal folds, including polyps, vocal nodules and Reinke’s edema. Myxoid and angiomatous types of the polyps were separately assessed. Videofibrolaryngoscopy was performed using an Olympus TYPE 150 bronchofibroscope (Germany). Morphological studies were carried out using a DMRXA microscope (Leika, Germany) by means of the ImageScopeM computer program (Germany). The uniformly treated sections were stained with Hematoxylin & Eosin (Biovitrum, Russia). Immunohistochemical quantitative assessment of the main T cell populations (CD3+, CD4+, CD8+), B cells (CD20+), histiocytes (CD68+), and the cells expressing bcl-2 and p53 cell regulators was carried out automatically using the BenchMarkXT immunohistotainer (Ventana, USA). The results were expressed as U/mm2. Results and Discussion. Some special features of cellular immunophenotype were revealed in exudative lesions of Reinke’s space. Reinke’s edema was characterized by high content of CD3+ lymphocytes, CD4+, CD8+, CD20+, p53 positive cells of the basal epithelium, as well as low numbers of CD68+, bcl-2 positive lymphocytes and cells of the basal epithelium. Myxoid type of polyps was characterized by low content of CD3+, CD4+, CD8+, CD20+ lymphocytes, bcl-2 positive lymphocytes and basal epithelium cells, CD68+ monocyte-macrophage cells, and high amounts of p53 positive basal epithelial cells. In the angioma-type polyps, we have registered low contents of CD3+, CD4+, CD8+, CD20+ lymphocytes, high numbers of monocyte-macrophage CD68+ cells, MMP-9+, bcl-2 positive lymphocytes, and low content of p53 positive cells of basal epithelium. The samples from the vocal nodules were characterized by low content of CD3+, CD4+, CD8+, CD20+ and p53 positive basal epithelial cells; high numbers of CD68+ cells (monocyte-macrophage series), MMP-9+ and bcl-2 positive lymphocytes