Research methods of properties of dissipative structures formed while the impulse energy input into the material

Впервые исследованы свойства диссипативных структур, образующихся при импульсном вводе энергии в материал.The properties of dissipative structures formed in materials under dynamic non-equilibrium processes are analyzed for the first time

Molecular Genetic Analysis of the Complete Genome of Tick-Borne Encephalitis Virus (Siberia Subtype): Modern Kolarovo-2008 Isolate

Determined is the complete genome sequence of Kolarovo-2008 strain (Siberia subtype) of Tick-borne encephalitis virus (TBEV), isolated from a tick in the suburbs of the Tomsk city. Nucleotide sequence analysis testifies of the fact that the level of genetic differences within the Siberian subtype of TBEV amounts to 10 % of the nucleotide sequence and to 7 % of amino-acid sequence for certain virus genes. 3'-HTO of the genome of Siberian subtype has the highest rate of variability and the homology level ranging from 65 to 97 %. Kolarovo-2008 and Vasilchenko (isolated in Novosibirsk in 1969) strains have the highest level of genome homology. The level of dissimilarity between the two Tomsk strains is substantially higher: the total number of amino-acid substitutions in Tomsk Zausaev and Kolarovo-2008 strains equals to 124, and 3'HTO level of homology is 79 %. Identified genetic variability of the Siberian subtype of TBEV is of a great importance for further development and enhancement of tick-borne encephalitis virus diagnostics

Analysis of Ebola virus Zaire 2014 isolates

Analysis of 5 Ebola virus Zaire 2014 isolates passaged in cell cultures or in mice, demonstrated presence of unique mutations in the genome RNA in some cases. All identified nucleotide substitutions are singular, stochastically located, synonymous or fall within non-coding regions. Variability level of nucleotide sequences is equal to 0.005-0.01 %, suggesting extremely high genetic stability of Ebola virus Zaire, the causative agent of the outbreak. Confirmed is suppression of non-synonymous mutations accumulation in ebolavirus variants in the course of time. Detected are alterations in glycosilation sites and mucin-like domain of ebolavirus glycoprotein

Detection of Specific Antibodies to Arboviruses in Blood Sera of Persons Residing in Kindia Province, the Republic of Guinea

The aim of the work was to detect specific antibodies to West Nile, dengue, CCHF, and chikungunya viruses in blood sera of Guinean Kindia Province residents.Materials and methods. The obtained sera were analyzed in ELISA to discover IgG antibodies to abovementioned viruses.Results and conclusions. Detected were 267 (82 %) positive samples out of 326, containing immunoglobulins of G class to these arboviruses. The obtained data provide evidence for active circulation of dengue and West Nile fevers agents in this territory. Further studies of immune strata of the population, and possible carriers and vectors of arboviruses were demonstrated to be advisable for optimization of approaches to prophylactic (anti-epidemic) measures implementation

The structure self-organization of sheet aluminium alloy while dynamical unbalanced process

Виявлено особливості деформування листового алюмінієвого сплаву при динамічних незрівноважених процесах. З використанням монокристального сенсора і розробленої методики оцінювання деформованого стану матеріалу на плоских зразках із застосуванням швидкісної фотозйомки отримано додаткову інформацію про утворення дисипативних, менш щільних, структур під час динамічних незрівноважених процесів.There are shown peculiarities of the deformation of aluminum alloy sheet in dynamic unbalanced processes. Additional information about forming of dissipation structures, which are less dense, was obtained using a monocystal sensor and optical strain field measurement method

New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

The present study a comprehensive analysis of the antibacterial properties of a composite material based on borosiloxane and zinc oxide nanoparticles (ZnO NPs). The effect of the polymer matrix and ZnO NPs on the generation of reactive oxygen species, hydroxyl radicals, and long-lived oxidized forms of biomolecules has been studied. All variants of the composites significantly inhibited the division of E. coli bacteria and caused them to detach from the substrate. It was revealed that the surfaces of a composite material based on borosiloxane and ZnO NPs do not inhibit the growth and division of mammalians cells. It is shown in the work that the positive effect of the incorporation of ZnO NPs into borosiloxane can reach 100% or more, provided that the viscoelastic properties of borosiloxane with nanoparticles are retained