229 research outputs found
Particular features of interrelation of motivation, values and sense of lifeβs meaning as subjective factors of individualizing trajectory in the system of continuous education
The relevance of the problem under study is based on the fact that, as regards methodological and theoretical aspects, the problem of value and motivational sphere is poorly elaborated regarding the interrelation between professional education and professional activity and on the empirical level there is no clear understanding of how the sense of purpose of life and own professional values is related to the professional motivation. The aim of the article is to identify the specific features of the interrelation and effects of meaning of life to the professional values and motivation. The leading method of research is questionnaire method which makes it possible to identify the following: level of sense of lifeβs purpose β method of life-meaning orientations, specific features of professional motivation β method βMotivation of professional activityβ and method βLevel of correlation between value and availability of valueβ. The article presents and discusses the results of empirical study of the interrelation between professional values, professional motivation and life-meaning orientations, as well as the effects of the level of lifeβs meaning on professional motivation. The practical value is the possibility to use the results of the research in developing programs for correcting and increasing professional motivation, as well as for developing technologies of psychology-pedagogical assistance to sense-making and professional self-identification in projecting and implementing individual educational trajectories in the continuous vocational education system. The article can be useful for specialists in professiology, teachers of technical subjects and professional consultants for forecasting professional development of a person. Β© 2016 Zavodchikov et al
Willingness to university teachers to training of disabled persons and persons with disabilities
The article raises the question of the availability of the teaching staff of higher educational institutions for learning disabled people and people with disabilities, and provides recommendations for the development of specific competenciesΠ ΡΡΠ°ΡΡΠ΅ ΡΡΠ°Π²ΠΈΡΡΡ Π²ΠΎΠΏΡΠΎΡ ΠΎ Π³ΠΎΡΠΎΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠΎΡΡΠΊΠΎ-ΠΏΡΠ΅ΠΏΠΎΠ΄Π°Π²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° Π²ΡΡΡΠΈΡ
ΡΡΠ΅Π±Π½ΡΡ
Π·Π°Π²Π΅Π΄Π΅Π½ΠΈΠΉ ΠΊ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ ΠΈΠ½Π²Π°Π»ΠΈΠ΄ΠΎΠ² ΠΈ Π»ΠΈΡ Ρ ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½Π½ΡΠΌΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΠΌΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ, ΠΈ Π΄Π°ΡΡΡΡ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ Π΄Π»Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠΏΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈ
Medical and social characteristics of children with tuberculosis in conditions of social insufficiency in the Irkutsk region
Background. In cases of tuberculosis in children, contacts with patients with drug-resistant forms are often detected. Treatment and prevention of the disease is based on these data and adherence to treatment. Aims. To analyze the social status of the family of children with tuberculosis, clinical forms and drug resistance of MBT in patients who are sources of infection in the outbreak for adequate planning of preventive treatment of contact and treatment of children with tuberculosis. Materials and methods. The study involved 150 children with tuberculosis treated in a hospital in 2009-2012 and 142 children - in 2015-2017. We studied social factors and drug resistance of Mycobacterium tuberculosis in adult patients - sources to child transmission. Drug resistance of MBT cultures was determined by LΓΆwenstein - Jensen medium and automated system BACTEC MGIT 960. Results. 50.0 % of children with tuberculosis are patients of preschool age, 33.0 % of children aged under 3 years. From 2009-2012 to 2015-2017 the proportion of socially disadvantaged families fell from 68.0 % to 45.1 %. At the same time the proportion of children with tuberculosis, contracted from a known contact decreased from 70.0 % to 57.0 %. Often children get infected from mother or from several close relatives (mother, father, grandfather, grandmother), TB patients source of infection of children are often diagnosed with infiltrative (21.9-38.3 %) and fibro-cavernous tuberculosis (17.0-21.0 %). To 2015-2017 multi-drug resistance in the nidi was recorded at 52.2 %. The development of tuberculosis in children was facilitated by the defects of preventative measures: absence of BCG vaccination (from 9.0 to 14.0 % of children), the absence of preventive treatment (55.3-67.5 %)
The effects of innovative changes influence on social and economic processes of the region development
Development of strategy of social and economic development of the Voronezh region till 2035 requires the careful analysis of a condition of all activities of the region, their interaction and interference. The special role in this process belongs to the higher school as the engine of knowledge, information and innovations. In case of all conservatism of an education system its task not only to give estimates and forecasts of the future, but also to serve as a leader of changes in all industries. The models realizing these tasks are a possibility of receipt of the effective instrument of increase in innovation of potential of economy of the region, forming of the environment which is adequately reflecting scientific and technical and economic challenges of modern realities and also developments of processes and technologies of transition of economy of the region to the principles of digital economy. Direct task of the higher school are increase in the amount of knowledge which is saved up by society, handling and transformation of information to knowledge, generation of new information and new knowledge, forming of the competitive specialist. In article approaches to an impact assessment of changes in the higher school on processes of social and economic development of the region, to classification of straight lines and side effects (spillover-effects) in the conditions of development of programs of a strategic development of the region are considered, the model of development of the higher school taking into account spillover-effect based on the principles of digital economy is offered. For the purpose of an impact assessment of changes in the higher school on processes of social and economic development in the region the task is set to analyse influence of various factors at each other, and also on basic factors of economic growth of the region
ROLE OF SYSTEMATIC INFLAMMATION IN THE DEVELOPMENT OF COMORBIDITY IN CASE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Often local inflammation develops into systemic one with total inflammatory response of endotheliocytes, plasma and cellular blood factors, connective tissue, and at the final stages it is manifested through microcirculatory disorders in vital organs and tissues. At present two aspects are being investigated related to systemic inflammation in chronic obstructive pulmonary disease (COPD). Firstly, it is the evaluation of inflammatory load through testing the level of inflammation markers in blood. Secondly, now it is generally recognized that a number of typical extrapulmonary disorders and concurrent diseases develops in COPD patients. Regardless of these general pathogenic mechanisms, the one thing is clear: cardiovascular diseases, body weight loss, osteoporosis and a number of other extrapulmonary manifestations of COPD are related to systematic inflammatory response
ΠΡΠ΅Π½ΠΊΠ° Π΄ΠΎΠ· ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΈ ΠΈΡ ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΈΠΊΠΎΠ² ΠΏΡΠΈ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΠΈ ΡΡΡΠΎΠ½ΡΠΈΡ-89,90
In radiobiology circulating T-lymphocytes are used as βnatural biodosimetersβ since the frequency of chromosomal aberrations that occur in them after radiation exposure is proportional to the accumulated dose. In addition, stable chromosomal aberrations (translocations) are detected in them years and decades after radiation exposure. Estimation of doses to circulating lymphocytes requires consideration of two dose components: the dose accumulated by the lymphocyte precursors (progenitors) in the red bone marrow; and dose accumulated by the lymphocytes in the lymphoid organs/tissues during circulation. A recently created model of T-lymphocyte exposure takes into account all these dose components, as well as the age-dependent dynamics of T-lymphocytes. The use of a model approach is especially important in assessing doses from osteotropic beta emitters (89,90Sr). They accumulate in the bone and locally expose predominately bone marrow. The dose to other lymphoid organs and tissues is much lower. The objective of this study is to evaluate the conversion factors from ingested 89,90Sr to the cumulative dose to circulating T-lymphocytes and their progenitors (DCL). For calculations, the previously developed model of T-lymphocyte exposure and new dose coefficients for the red bone marrow, estimated on the basis of a sex-and-age-dependent biokinetic model and a new dosimetric model of the human skeleton were used. As a result, the DCL values were evaluated for the first time. The age at the time of 89,90Sr intake varied from a newborn to 35 years, the age of T-lymphocyte examination (blood sampling age) was up to 75 years. The maximum values of DCL for both 90Sr and 89Sr were typical of children in the first years of life. It has been shown that doses to circulating T-lymphocytes from these radionuclides are lower than those to bone marrow, but are significantly higher than doses to other lymphoid tissues. The effect of sex on DCL is manifested for children 10 years of age and older. The area of DCL application covers the population of radioactively contaminated territories (the Urals region, the zone of the Chernobyl accident), as well as personnel of the nuclear industry enterprises.Π¦ΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠΈΠ΅ Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡΡΡ Π² ΡΠ°Π΄ΠΈΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΊΠ°ΠΊ Β«Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠ΅ Π±ΠΈΠΎΠ΄ΠΎΠ·ΠΈΠΌΠ΅ΡΡΡΒ», ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΡΠ°ΡΡΠΎΡΠ° Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ½ΡΡ
Π°Π±Π΅ΡΡΠ°ΡΠΈΠΉ, Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡΠΈΡ
Π² Π½ΠΈΡ
ΠΏΠΎΡΠ»Π΅ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ, ΠΏΡΠΎΠΏΠΎΡΡΠΈΠΎΠ½Π°Π»ΡΠ½Π° Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅. ΠΠΎΠ»Π΅Π΅ ΡΠΎΠ³ΠΎ, ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΠ΅ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ½ΡΠ΅ Π°Π±Π΅ΡΡΠ°ΡΠΈΠΈ (ΡΡΠ°Π½ΡΠ»ΠΎΠΊΠ°ΡΠΈΠΈ) ΠΎΠ±Π½Π°ΡΡΠΆΠΈΠ²Π°ΡΡΡΡ Π² Π½ΠΈΡ
ΡΠΏΡΡΡΡ Π³ΠΎΠ΄Ρ ΠΈ Π΄Π΅ΡΡΡΠΈΠ»Π΅ΡΠΈΡ ΠΏΠΎΡΠ»Π΅ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ. ΠΡΠ΅Π½ΠΊΠ° Π΄ΠΎΠ· Π½Π° ΡΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠΈΠ΅ Π»ΠΈΠΌΡΠΎΡΠΈΡΡ ΡΡΠ΅Π±ΡΠ΅Ρ ΡΡΠ΅ΡΠ° 2 ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ²: Π΄ΠΎΠ·Ρ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΠΎΠΉ ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΈΠΊΠ°ΠΌΠΈ (ΠΏΡΠΎΠ³Π΅Π½ΠΈΡΠΎΡΠ°ΠΌΠΈ) Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² Π² ΠΊΡΠ°ΡΠ½ΠΎΠΌ ΠΊΠΎΡΡΠ½ΠΎΠΌ ΠΌΠΎΠ·Π³Π΅; Π΄ΠΎΠ·Ρ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΠΎΠΉ Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°ΠΌΠΈ Π² Π»ΠΈΠΌΡΠΎΠΈΠ΄Π½ΡΡ
ΠΎΡΠ³Π°Π½Π°Ρ
/ΡΠΊΠ°Π½ΡΡ
ΠΏΡΠΈ ΡΠΈΡΠΊΡΠ»ΡΡΠΈΠΈ. ΠΠ΅Π΄Π°Π²Π½ΠΎ ΡΠΎΠ·Π΄Π°Π½Π½Π°Ρ ΠΌΠΎΠ΄Π΅Π»Ρ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ ΡΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠΈΡ
Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΡΡΠΈΡΡΠ²Π°Π΅Ρ Π²ΡΠ΅ ΡΡΠΈ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΡ, Π° ΡΠ°ΠΊΠΆΠ΅ Π²ΠΎΠ·ΡΠ°ΡΡΠ½ΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ². ΠΡΠΎΠ±Π΅Π½Π½ΠΎ Π²Π°ΠΆΠ½ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π° ΠΏΡΠΈ ΠΎΡΠ΅Π½ΠΊΠ΅ Π΄ΠΎΠ· ΠΎΡ ΠΎΡΡΠ΅ΠΎΡΡΠΎΠΏΠ½ΡΡ
Π±Π΅ΡΠ°-ΠΈΠ·Π»ΡΡΠ°ΡΠ΅Π»Π΅ΠΉ (89,90Sr). ΠΠΎΡΠ»Π΅ ΠΏΠΎΠΏΠ°Π΄Π°Π½ΠΈΡ Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΠΎΠ½ΠΈ Π½Π°ΠΊΠ°ΠΏΠ»ΠΈΠ²Π°ΡΡΡΡ Π² ΠΊΠΎΡΡΠΈ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΎ ΠΎΠ±Π»ΡΡΠ°ΡΡ ΠΊΠΎΡΡΠ½ΡΠΉ ΠΌΠΎΠ·Π³, ΡΠ°ΠΊ ΡΡΠΎ Π΄ΠΎΠ·Π° Π½Π° Π΄ΡΡΠ³ΠΈΠ΅ Π»ΠΈΠΌΡΠΎΠΈΠ΄Π½ΡΠ΅ ΠΎΡΠ³Π°Π½Ρ ΠΈ ΡΠΊΠ°Π½ΠΈ ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅ΡΡΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π½ΠΈΠΆΠ΅. Π¦Π΅Π»ΡΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΡΠ΅Π½ΠΊΠ° ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄Π° ΠΎΡ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΡ 89,90Sr ΠΊ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅ Π½Π° ΡΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠΈΠ΅ Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΡ ΠΈ ΠΈΡ
ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΈΠΊΠΎΠ² (ΠΠL). ΠΠ»Ρ ΡΠ°ΡΡΠ΅ΡΠΎΠ² ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΡΡ ΡΠ°Π½Π΅Π΅ ΠΌΠΎΠ΄Π΅Π»Ρ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΈ Π½ΠΎΠ²ΡΠ΅ Π΄ΠΎΠ·ΠΎΠ²ΡΠ΅ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΡ Π΄Π»Ρ ΠΊΡΠ°ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°, ΠΎΡΠ΅Π½Π΅Π½Π½ΡΠ΅ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΠΎΠ»ΠΎΠ²ΠΎΠ·ΡΠ°ΡΡΠ½ΠΎΠΉ Π±ΠΈΠΎΠΊΠΈΠ½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΈ Π½ΠΎΠ²ΠΎΠΉ Π΄ΠΎΠ·ΠΈΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΡΠΊΠ΅Π»Π΅ΡΠ° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΏΡΠΎΠ΄Π΅Π»Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ Π±ΡΠ»ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΠΠL. ΠΠΎΠ·ΡΠ°ΡΡ Π½Π° ΠΌΠΎΠΌΠ΅Π½Ρ ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΡ 89,90Sr Π²Π°ΡΡΠΈΡΠΎΠ²Π°Π» ΠΎΡ Π½ΠΎΠ²ΠΎΡΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠ³ΠΎ Π΄ΠΎ 35 Π»Π΅Ρ, Π²ΠΎΠ·ΡΠ°ΡΡ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² (Π²ΠΎΠ·ΡΠ°ΡΡ Π·Π°Π±ΠΎΡΠ° ΠΊΡΠΎΠ²ΠΈ) β Π΄ΠΎ 75 Π»Π΅Ρ. ΠΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΡΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΡ Π΄ΠΎΠ·ΠΎΠ²ΡΡ
ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠΎΠ², ΠΊΠ°ΠΊ Π΄Π»Ρ 90Sr, ΡΠ°ΠΊ ΠΈ Π΄Π»Ρ 89Sr, Π±ΡΠ»ΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½Ρ Π΄Π»Ρ Π΄Π΅ΡΠ΅ΠΉ ΠΏΠ΅ΡΠ²ΡΡ
Π»Π΅Ρ ΠΆΠΈΠ·Π½ΠΈ. ΠΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π΄ΠΎΠ·Ρ Π½Π° ΡΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠΈΠ΅ Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΡ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡΡΡ Π½ΠΈΠΆΠ΅, ΡΠ΅ΠΌ Π΄ΠΎΠ·Ρ Π½Π° ΠΠΠ ΠΎΡ ΡΡΠΈΡ
ΡΠ°Π΄ΠΈΠΎΠ½ΡΠΊΠ»ΠΈΠ΄ΠΎΠ², Π½ΠΎ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π²ΡΡΠ΅, ΡΠ΅ΠΌ Π΄ΠΎΠ·Ρ Π½Π° Π΄ΡΡΠ³ΠΈΠ΅ Π»ΠΈΠΌΡΠΎΠΈΠ΄Π½ΡΠ΅ ΡΠΊΠ°Π½ΠΈ. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠΎΠ»Π° Π½Π° ΠΠL Π²ΡΡΠ°ΠΆΠ΅Π½ΠΎ Π΄Π»Ρ Π΄Π΅ΡΠ΅ΠΉ 10 Π»Π΅Ρ ΠΈ ΡΡΠ°ΡΡΠ΅. ΠΠ±Π»Π°ΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΠL ΠΎΡ
Π²Π°ΡΡΠ²Π°Π΅Ρ ΡΠ°Π±ΠΎΡΠ½ΠΈΠΊΠΎΠ² ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΠΉ Π°ΡΠΎΠΌΠ½ΠΎΠΉ ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΡΡΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΠ΅ ΡΠ°Π΄ΠΈΠΎΠ°ΠΊΡΠΈΠ²Π½ΠΎ Π·Π°Π³ΡΡΠ·Π½Π΅Π½Π½ΡΡ
ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΉ (Π£ΡΠ°Π»ΡΡΠΊΠΈΠΉ ΡΠ΅Π³ΠΈΠΎΠ½, Π·ΠΎΠ½Π° Π§Π΅ΡΠ½ΠΎΠ±ΡΠ»ΡΡΠΊΠΎΠΉ Π°Π²Π°ΡΠΈΠΈ)
ANALYSIS OF THE RESULTS OF SURGICAL PROCEDURES ADVISABLE FOR CHRONIC PANCREATITIS WITH THE PREDOMINANT LESION OF THE PANCREATIC HEAD
Recently, studies comparing various variants of operations to establish the optimal method of surgical treatmentΒ for chronic pancreatitis with pancreatic head lesions from the point of view of evidence-based medicine have beenΒ carried out in the world. However, these comparative studies do not take into account differences in the clinical andΒ morphological forms of the disease, in particular, chronic pancreatitis with a predominant and isolated lesion of the head.Β Subtotal resection of the pancreatic head with proximal pancreatojejunostomy, suitable for an isolated lesion of the head,Β does not solve all the problems of chronic pancreatitis with a predominant lesion of the head. In this case, the violationΒ of the outflow of pancreatic juice along the pathologically changed main pancreatic duct from the left half of the glandΒ is not eliminated. It is impossible to unambiguously support the hypothesis of the feasibility of performing subtotalΒ resection of the pancreatic head with proximal pancreatojejunostomy in chronic pancreatitis with a predominant lesionΒ of the head with a uniformly expanded main pancreatic duct. With this form of chronic pancreatitis, cicatricial stricturesΒ can form in the main pancreatic duct, which can lead to ductal hypertension and serve as an indication for reoperation.Β The feasibility of using Beger operation in chronic pancreatitis with a predominant lesion of the head is doubtful, sinceΒ the intersection of the isthmus and the need for a T-shaped longitudinal pancreatojejunostomy makes this interventionΒ technically difficult and unsafe. Based on the studies performed, it is impossible to say with certainty about the reliableΒ advantages of one type of operations over another. To obtain reliable results, itβs necessary to conduct evidence-basedΒ studies comparing subtotal resection of the pancreatic head with longitudinal pancreatojejunostomy with other typesΒ of interventions only for chronic pancreatitis with a predominant head lesion, excluding from the study patients withΒ chronic pancreatitis with isolated head lesion
ΠΠ΅ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΡΡΡ ΠΎΡΠ΅Π½ΠΊΠΈ Π΄ΠΎΠ· Π² ΠΊΠΎΡΡΠ½ΠΎΠΌ ΠΌΠΎΠ·Π³Π΅ ΠΎΡ 89,90Sr ΠΈΠ·-Π·Π° ΠΈΠ·ΠΌΠ΅Π½ΡΠΈΠ²ΠΎΡΡΠΈ Ρ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° ΠΈ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ ΠΊΠΎΡΡΠΈ
Dosimetric modeling of radiation transport in skeletal bone tissues using computational phantoms provides the doses of internal exposure to active marrow. Computational phantoms of ICRP are created for reference people with anatomical and physiological characteristics typical of an average individual. The doses calculated with such phantoms will correspond to certain population-average values. Individual variability will introduce a stochastic component of uncertainty into the dose estimation. The objective of this study is to assess the influence of variability of chemical composition and bone density on the results of dosimetric modeling. The phantoms are represented by simple geometry figures filled with trabecular structures and bone marrow and covered with a cortical layer. Radiation transport was simulated using the Monte Carlo method. The dose factors to convert the radionuclide activity concentration to absorbed dose rates in active marrow were calculated assuming uniform radionuclide distribution in the volume of the trabecular and cortical bone. As a result of the numerical experiments, it has been shown that variations in chemical composition do not introduce an error of more than Β± 4% into dosimetric modeling. The effect of bone density on active marrow dose formation depends on the size of a phantom. For computational phantoms with linear dimensions exceeding two electron free path lengths (~ 0.44 cm), variability of bone density within Β± 3% leads to a similar relative uncertainty of the dose conversion factor. However, for smaller phantoms, bone density variability leads to uncertainties of 6% or 13% for a source deposited in the trabecular or cortical bone, respectively. The results obtained will be used to assess the uncertainty of bone marrow dosimetry, taking into account the uncertainty of all parameters including the variability of morphometric characteristics of bones, the variability of the active marrow distribution in skeletal sites, as well as the uncertainties introduced by model approximations.ΠΠ»Ρ ΡΠ°ΡΡΠ΅ΡΠ° Π΄ΠΎΠ· Π²Π½ΡΡΡΠ΅Π½Π½Π΅Π³ΠΎ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ ΠΊΡΠ°ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΡΡΡ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ° ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΠΉ Π² ΡΠΊΠ°Π½ΡΡ
ΠΊΠΎΡΡΠ΅ΠΉ ΡΠΊΠ΅Π»Π΅ΡΠ° Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π²ΡΡΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ°Π½ΡΠΎΠΌΠΎΠ². ΠΡΡΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΠ°Π½ΡΠΎΠΌΡ ΠΠΠ Π ΡΠΎΠ·Π΄Π°Π½Ρ Π΄Π»Ρ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Ρ Π°Π½Π°ΡΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ, ΡΠΈΠΏΠΈΡΠ½ΡΠΌΠΈ Π΄Π»Ρ ΡΡΠ΅Π΄Π½Π΅ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΡΠΌΠ°. ΠΠΎΠ·Ρ, ΡΠ°ΡΡΡΠΈΡΡΠ²Π°Π΅ΠΌΡΠ΅ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ°ΠΊΠΈΡ
ΡΠ°Π½ΡΠΎΠΌΠΎΠ², Π±ΡΠ΄ΡΡ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΎΠ²Π°ΡΡ Π½Π΅ΠΊΠΈΠΌ ΡΡΠ΅Π΄Π½Π΅ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΎΠ½Π½ΡΠΌ, Π° ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½Π°Ρ ΠΈΠ·ΠΌΠ΅Π½ΡΠΈΠ²ΠΎΡΡΡ Π±ΡΠ΄Π΅Ρ Π²Π½ΠΎΡΠΈΡΡ ΡΡΠΎΡ
Π°ΡΡΠΈΡΠ΅ΡΠΊΡΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΡ Π½Π΅ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΡΡΠΈ Π² ΠΎΡΠ΅Π½ΠΊΡ Π΄ΠΎΠ·. Π¦Π΅Π»ΡΡ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΡΠ΅Π½ΠΊΠ° Π²Π»ΠΈΡΠ½ΠΈΡ Π²Π°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΠΎΡΡΠΈ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° ΠΈ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ ΠΊΠΎΡΡΠΈ Π½Π° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π΄ΠΎΠ·ΠΈΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ Π²ΡΡΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΠ°Π½ΡΠΎΠΌΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΊΠΎΡΡΠ΅ΠΉ ΡΠΊΠ΅Π»Π΅ΡΠ°, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΏΡΠΎΡΡΡΠΌΠΈ Π³Π΅ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠΈΠ³ΡΡΠ°ΠΌΠΈ, Π·Π°ΠΏΠΎΠ»Π½Π΅Π½Π½ΡΠΌΠΈ ΡΡΠ°Π±Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΌΠΈ ΡΡΡΡΠΊΡΡΡΠ°ΠΌΠΈ ΠΈ ΠΊΠΎΡΡΠ½ΡΠΌ ΠΌΠΎΠ·Π³ΠΎΠΌ ΠΈ ΠΏΠΎΠΊΡΡΡΡΠΌΠΈ ΡΠ½Π°ΡΡΠΆΠΈ ΠΊΠΎΡΡΠΈΠΊΠ°Π»ΡΠ½ΡΠΌ ΡΠ»ΠΎΠ΅ΠΌ. ΠΠ΅ΡΠ΅Π½ΠΎΡ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΠΉ ΠΈΠΌΠΈΡΠΈΡΠΎΠ²Π°Π»ΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΠΎΠ½ΡΠ΅-ΠΠ°ΡΠ»ΠΎ. Π Π°ΡΡΡΠΈΡΡΠ²Π°Π»ΠΈΡΡ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΡ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄Π° ΠΎΡ ΡΠ΄Π΅Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ°Π΄ΠΈΠΎΠ½ΡΠΊΠ»ΠΈΠ΄ΠΎΠ² ΠΊ ΠΌΠΎΡΠ½ΠΎΡΡΠΈ ΠΏΠΎΠ³Π»ΠΎΡΠ΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Ρ Π² ΠΊΡΠ°ΡΠ½ΠΎΠΌ ΠΊΠΎΡΡΠ½ΠΎΠΌ ΠΌΠΎΠ·Π³Π΅ ΠΏΡΠΈ ΠΈΡ
ΡΠ°Π²Π½ΠΎΠΌΠ΅ΡΠ½ΠΎΠΌ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ Π² ΠΎΠ±ΡΠ΅ΠΌΠ΅ ΡΡΠ°Π±Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ Π»ΠΈΠ±ΠΎ ΠΊΠΎΡΡΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΠΊΠΎΡΡΠΈ. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ°ΡΡΠ΅ΡΠΎΠ² ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΡ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠΈΠ΅ ΠΊΠΎΠ½Π²Π΅ΡΡΠΈΡΠΎΠ²Π°ΡΡ ΡΠ΄Π΅Π»ΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ°Π΄ΠΈΠΎΠ½ΡΠΊΠ»ΠΈΠ΄Π° Π² Π΅Π΄ΠΈΠ½ΠΈΡΡ ΠΌΠΎΡΠ½ΠΎΡΡΠΈ ΠΏΠΎΠ³Π»ΠΎΡΠ΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Ρ Π² ΠΊΡΠ°ΡΠ½ΠΎΠΌ ΠΊΠΎΡΡΠ½ΠΎΠΌ ΠΌΠΎΠ·Π³Π΅. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΡΠΈΡΠ»Π΅Π½Π½ΡΡ
ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠΎΠ² Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π²Π°ΡΠΈΠ°ΡΠΈΠΈ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° Π² ΠΏΡΠ΅Π΄Π΅Π»Π°Ρ
ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π½Π΅ Π²Π½ΠΎΡΡΡ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΠ³ΡΠ΅ΡΠ½ΠΎΡΡΠΈ Π±ΠΎΠ»ΡΡΠ΅ Β±4% Π² Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ Π΄ΠΎΠ· Π½Π° ΠΊΡΠ°ΡΠ½ΡΠΉ ΠΊΠΎΡΡΠ½ΡΠΉ ΠΌΠΎΠ·Π³. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Π½Π° ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΎΠ·Ρ Π² ΠΊΡΠ°ΡΠ½ΠΎΠΌ ΠΊΠΎΡΡΠ½ΠΎΠΌ ΠΌΠΎΠ·Π³Π΅ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΡΠ°Π·ΠΌΠ΅ΡΠ° ΡΠ°Π½ΡΠΎΠΌΠ°. ΠΠ»Ρ ΡΠ°Π½ΡΠΎΠΌΠΎΠ², ΡΡΠΈ Π»ΠΈΠ½Π΅ΠΉΠ½ΡΠ΅ ΡΠ°Π·ΠΌΠ΅ΡΡ ΠΏΡΠ΅Π²ΡΡΠ°ΡΡ Π΄Π²Π΅ Π΄Π»ΠΈΠ½Ρ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΠ±Π΅Π³Π° ΡΠ»Π΅ΠΊΡΡΠΎΠ½ΠΎΠ² (~ 0,44 ΡΠΌ), Π²Π°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΠΎΡΡΡ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Π² ΠΏΡΠ΅Π΄Π΅Π»Π°Ρ
Β±3% ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π°Π½Π°Π»ΠΎΠ³ΠΈΡΠ½ΠΎΠΉ ΠΏΠΎ Π²Π΅Π»ΠΈΡΠΈΠ½Π΅ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π½Π΅ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΡΡΠΈ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄Π°. ΠΠ΄Π½Π°ΠΊΠΎ Π΄Π»Ρ ΡΠ°Π½ΡΠΎΠΌΠΎΠ² ΠΌΠ΅Π½ΡΡΠΈΡ
ΡΠ°Π·ΠΌΠ΅ΡΠΎΠ² Π²Π°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΠΎΡΡΡ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π½Π΅ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΡΡΡΠΌ ΡΡΠΈΡ
ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠ°Π²Π½ΡΠΌ 6% ΠΈΠ»ΠΈ 13%, Π΅ΡΠ»ΠΈ ΠΈΡΡΠΎΡΠ½ΠΈΠΊ Π΄Π΅ΠΏΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ Π² ΡΡΠ°Π±Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ ΠΈΠ»ΠΈ ΠΊΠΎΡΡΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΠΊΠΎΡΡΠΈ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π±ΡΠ΄ΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΠΏΡΠΈ ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΡΠΌΠΌΠ°ΡΠ½ΠΎΠΉ Π½Π΅ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΡΡΠΈ ΠΏΠΎΠ³Π»ΠΎΡΠ΅Π½Π½ΡΡ
Π΄ΠΎΠ· ΠΊΡΠ°ΡΠ½ΡΠΌ ΠΊΠΎΡΡΠ½ΡΠΌ ΠΌΠΎΠ·Π³ΠΎΠΌ Ρ ΡΡΠ΅ΡΠΎΠΌ Π½Π΅ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΡΡΠΈ Π²ΡΠ΅Ρ
ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ², Π²ΠΊΠ»ΡΡΠ°Ρ Π²Π°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΠΎΡΡΡ ΠΌΠΎΡΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ ΠΊΠΎΡΡΠ΅ΠΉ, Π²Π°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΊΡΠ°ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΡΡΠΊΡΡΡΠ°ΠΌΠΈ ΡΠΊΠ΅Π»Π΅ΡΠ°, Π° ΡΠ°ΠΊΠΆΠ΅ Π½Π΅ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΡΡΡ, ΠΏΡΠΈΠ²Π½ΠΎΡΠΈΠΌΡΡ ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΡΠΌΠΈ ΠΏΡΠΈΠ±Π»ΠΈΠΆΠ΅Π½ΠΈΡΠΌΠΈ
ΠΡΠ΅Π½ΠΊΠ° Π΄ΠΎΠ· ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΏΡΠΈ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΠΈ ΡΠ°Π΄ΠΈΠΎΠ½ΡΠΊΠ»ΠΈΠ΄ΠΎΠ² ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΡΠΎΠΏΠ½ΠΎΡΡΠΈ
Assessment of the lymphocyte doses is relevant for solving a number of radiobiological problems, including the risk assessment of hemoblastosis (leukemia, multiple myeloma, lymphoma etc.), as well as the use of circulating lymphocytes as βnatural biodosimetersβ. The latter is because the frequency of chromosomal aberrations occurring in lymphocytes following radiation exposure is proportional to the accumulated dose. Assessment of doses to the circulating lymphocytes requires due account of: first, the dose accumulated by the lymphocyte progenitors in the red bone marrow; and second, the dose accumulated during lymphocyte circulation through lymphoid organs. The models presented by International Commission on Radiological Protection (ICRP-67, ICRP-100) allow calculating the dose for specific lymphoid organs based on known level of radionuclide intakes. A recently developed model of circulating T-lymphocyte irradiation takes into account all sources of exposure and age-related dynamics of T-lymphocytes: (1) exposure of lymphocyte progenitors in red bone marrow: (2) exposure of T-lymphocytes in the lymphoid organs, taking into account the proportion of resident lymphocytes and the residence time of circulating lymphocytes in the specific lymphoid organs. The objective of the study is to assess the dose coefficients allowing for the transition from the ingestion ofΒ 141,144Ce,Β 95Zr,Β 103,106Ru,Β 95Nb to the doses accumulated in circulating T-lymphocytes. For calculations, we used the dose coefficients from ICRP publications for specific lymphoid organs, as well as published data on the residence time of circulating lymphocytes in lymphoid organs and tissues. As a result, it was shown that the doses in circulating T-lymphocytes are higher than those in the red bone marrow, but lower than the doses to the colon wall. The dose coefficients were age dependent; the maximum values were typical for newborns. The obtained dose coefficients forΒ 141,144Ce,Β 95Zr,Β 95Nb andΒ 103,106Ru can be used to estimate the tissue and organ doses based on data on the frequency of chromosomal aberrations in peripheral blood lymphocytes.ΠΡΠ΅Π½ΠΊΠ° Π΄ΠΎΠ· Π½Π° Π»ΠΈΠΌΡΠΎΡΠΈΡΡ Π°ΠΊΡΡΠ°Π»ΡΠ½Π° Π² ΡΠ²Π΅ΡΠ΅ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΡΡΠ΄Π° ΡΠ°Π΄ΠΈΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΠ±Π»Π΅ΠΌ, Π²ΠΊΠ»ΡΡΠ°Ρ ΠΎΡΠ΅Π½ΠΊΡ ΡΠΈΡΠΊΠ° ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π³Π΅ΠΌΠΎΠ±Π»Π°ΡΡΠΎΠ·ΠΎΠ² (Π»Π΅ΠΉΠΊΠΎΠ·, ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΌΠΈΠ΅Π»ΠΎΠΌΠ°, Π»ΠΈΠΌΡΠΎΠΌΠ° ΠΈ Π΄Ρ.), Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΡΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠΈΡ
Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Β«Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
Π±ΠΈΠΎΠ΄ΠΎΠ·ΠΈΠΌΠ΅ΡΡΠΎΠ²Β». ΠΠΎΡΠ»Π΅Π΄Π½Π΅Π΅ ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ ΡΠ΅ΠΌ, ΡΡΠΎ ΡΠ°ΡΡΠΎΡΠ° Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ½ΡΡ
Π°Π±Π΅ΡΡΠ°ΡΠΈΠΉ, Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡΠΈΡ
Π² Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°Ρ
ΠΏΠΎΡΠ»Π΅ Π»ΡΡΠ΅Π²ΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ, ΠΏΡΠΎΠΏΠΎΡΡΠΈΠΎΠ½Π°Π»ΡΠ½Π° Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅. ΠΡΠ΅Π½ΠΊΠ° Π΄ΠΎΠ· Π½Π° ΡΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠΈΠ΅ Π»ΠΈΠΌΡΠΎΡΠΈΡΡ ΡΡΠ΅Π±ΡΠ΅Ρ ΡΡΠ΅ΡΠ° Π΄Π²ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ²: Π²ΠΎ-ΠΏΠ΅ΡΠ²ΡΡ
, Π΄ΠΎΠ·Ρ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΠΎΠΉ ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΈΠΊΠ°ΠΌΠΈ (ΠΏΡΠΎΠ³Π΅Π½ΠΈΡΠΎΡΠ°ΠΌΠΈ) Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² Π² ΠΊΡΠ°ΡΠ½ΠΎΠΌ ΠΊΠΎΡΡΠ½ΠΎΠΌ ΠΌΠΎΠ·Π³Π΅; Π° Π²ΠΎ-Π²ΡΠΎΡΡΡ
, Π΄ΠΎΠ·Ρ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΠΎΠΉ Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°ΠΌΠΈ Π² Π»ΠΈΠΌΡΠΎΠΈΠ΄Π½ΡΡ
ΠΎΡΠ³Π°Π½Π°Ρ
ΠΏΡΠΈ ΡΠΈΡΠΊΡΠ»ΡΡΠΈΠΈ. ΠΠΎΠ΄Π΅Π»ΠΈ, ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΡΠ΅ Π² ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΡΡ
ΠΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠΉ ΠΊΠΎΠΌΠΈΡΡΠΈΠΈ ΠΏΠΎ ΡΠ°Π΄ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π·Π°ΡΠΈΡΠ΅ (ICRP-67, ICRP-100), Π΄Π°ΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΡΠ°ΡΡΡΠΈΡΠ°ΡΡ Π΄ΠΎΠ·Ρ Π΄Π»Ρ ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΠΎΠ³ΠΎ Π»ΠΈΠΌΡΠΎΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΡΠ³Π°Π½Π° ΠΏΡΠΈ ΠΈΠ·Π²Π΅ΡΡΠ½ΠΎΠΌ ΡΡΠΎΠ²Π½Π΅ ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΡ ΡΠ°Π΄ΠΈΠΎΠ½ΡΠΊΠ»ΠΈΠ΄Π°. ΠΠ΅Π΄Π°Π²Π½ΠΎ ΡΠΎΠ·Π΄Π°Π½Π½Π°Ρ ΠΌΠΎΠ΄Π΅Π»Ρ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ ΡΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠΈΡ
Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΡΡΠΈΡΡΠ²Π°Π΅Ρ Π²ΡΠ΅ ΡΠ»Π°Π³Π°Π΅ΠΌΡΠ΅ Π΄ΠΎΠ·Ρ ΠΈ Π²ΠΎΠ·ΡΠ°ΡΡΠ½ΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ²: 1) ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΈΠΊΠΎΠ² Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² Π² ΠΊΡΠ°ΡΠ½ΠΎΠΌ ΠΊΠΎΡΡΠ½ΠΎΠΌ ΠΌΠΎΠ·Π³Π΅; 2) ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΠ΅ Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² Π² ΠΊΠ°ΠΆΠ΄ΠΎΠΌ Π»ΠΈΠΌΡΠΎΠΈΠ΄Π½ΠΎΠΌ ΠΎΡΠ³Π°Π½Π΅ Ρ ΡΡΠ΅ΡΠΎΠΌ Π΄ΠΎΠ»ΠΈ ΡΠ΅Π·ΠΈΠ΄Π΅Π½ΡΠ½ΡΡ
Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ ΠΏΡΠ΅Π±ΡΠ²Π°Π½ΠΈΡ ΡΠ°ΠΌ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ². Π¦Π΅Π»ΡΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΡΠ΅Π½ΠΊΠ° Π΄ΠΎΠ·ΠΎΠ²ΡΡ
ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠΈΡ
ΠΏΠ΅ΡΠ΅ΠΉΡΠΈ ΠΎΡ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΡ I4I,I44Ce, 95Zr, 103,106Ru, 95Nb ΠΊ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅ Π½Π° ΡΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠΈΠ΅ Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΡ. ΠΠ»Ρ ΡΠ°ΡΡΠ΅ΡΠΎΠ² ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈΡΡ Π΄ΠΎΠ·ΠΎΠ²ΡΠ΅ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΡ ΠΈΠ· ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ ΠΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠΉ ΠΊΠΎΠΌΠΈΡΡΠΈΠΈ ΠΏΠΎ ΡΠ°Π΄ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π·Π°ΡΠΈΡΠ΅ Π΄Π»Ρ ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΡΡ
Π»ΠΈΠΌΡΠΎΠΈΠ΄Π½ΡΡ
ΠΎΡΠ³Π°Π½ΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠΏΡΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΎΡΠ΅Π½ΠΊΠΈ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ, ΠΊΠΎΡΠΎΡΠΎΠ΅ ΡΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠΈΠ΅ Π»ΠΈΠΌΡΠΎΡΠΈΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΡΡ Π² ΡΡΠΈΡ
Π»ΠΈΠΌΡΠΎΠΈΠ΄Π½ΡΡ
ΠΎΡΠ³Π°Π½Π°Ρ
ΠΈ ΡΠΊΠ°Π½ΡΡ
. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π΄ΠΎΠ·Ρ Π½Π° ΡΠΈΡΠΊΡΠ»ΠΈΡΡΡΡΠΈΠ΅ Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΡ Π²ΡΡΠ΅, ΡΠ΅ΠΌ Π΄ΠΎΠ·Ρ Π½Π° ΠΊΡΠ°ΡΠ½ΡΠΉ ΠΊΠΎΡΡΠ½ΡΠΉ ΠΌΠΎΠ·Π³ ΠΎΡ ΡΡΠΈΡ
ΡΠ°Π΄ΠΈΠΎΠ½ΡΠΊΠ»ΠΈΠ΄ΠΎΠ², Π½ΠΎ Π½ΠΈΠΆΠ΅, ΡΠ΅ΠΌ Π΄ΠΎΠ·Ρ Π½Π° ΡΡΠ΅Π½ΠΊΡ ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ. Π Π°ΡΡΡΠΈΡΠ°Π½Π½ΡΠ΅ Π΄ΠΎΠ·ΠΎΠ²ΡΠ΅ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΡ Π·Π°Π²ΠΈΡΠ΅Π»ΠΈ ΠΎΡ Π²ΠΎΠ·ΡΠ°ΡΡΠ°; ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΡΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΡ Π±ΡΠ»ΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½Ρ Π΄Π»Ρ Π½ΠΎΠ²ΠΎΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ
. ΠΠ°Π½Π½ΡΠ΅ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΡ Π΄Π»Ρ 141,144Ce, 95Zr, 95Nb ΠΈ I03,I06Ru ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π΄ΠΎΠ· Π½Π° ΠΎΡΠ³Π°Π½Ρ ΠΈ ΡΠΊΠ°Π½ΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π΄Π°Π½Π½ΡΡ
ΠΎ ΡΠ°ΡΡΠΎΡΠ΅ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ½ΡΡ
Π°Π±Π΅ΡΡΠ°ΡΠΈΠΉ Π² Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°Ρ
ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ
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