229 research outputs found

    Particular features of interrelation of motivation, values and sense of life’s meaning as subjective factors of individualizing trajectory in the system of continuous education

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    The relevance of the problem under study is based on the fact that, as regards methodological and theoretical aspects, the problem of value and motivational sphere is poorly elaborated regarding the interrelation between professional education and professional activity and on the empirical level there is no clear understanding of how the sense of purpose of life and own professional values is related to the professional motivation. The aim of the article is to identify the specific features of the interrelation and effects of meaning of life to the professional values and motivation. The leading method of research is questionnaire method which makes it possible to identify the following: level of sense of life’s purpose – method of life-meaning orientations, specific features of professional motivation – method β€œMotivation of professional activity” and method β€œLevel of correlation between value and availability of value”. The article presents and discusses the results of empirical study of the interrelation between professional values, professional motivation and life-meaning orientations, as well as the effects of the level of life’s meaning on professional motivation. The practical value is the possibility to use the results of the research in developing programs for correcting and increasing professional motivation, as well as for developing technologies of psychology-pedagogical assistance to sense-making and professional self-identification in projecting and implementing individual educational trajectories in the continuous vocational education system. The article can be useful for specialists in professiology, teachers of technical subjects and professional consultants for forecasting professional development of a person. Β© 2016 Zavodchikov et al

    Willingness to university teachers to training of disabled persons and persons with disabilities

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    The article raises the question of the availability of the teaching staff of higher educational institutions for learning disabled people and people with disabilities, and provides recommendations for the development of specific competenciesΠ’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ ставится вопрос ΠΎ готовности профСссорско-ΠΏΡ€Π΅ΠΏΠΎΠ΄Π°Π²Π°Ρ‚Π΅Π»ΡŒΡΠΊΠΎΠ³ΠΎ состава Π²Ρ‹ΡΡˆΠΈΡ… ΡƒΡ‡Π΅Π±Π½Ρ‹Ρ… Π·Π°Π²Π΅Π΄Π΅Π½ΠΈΠΉ ΠΊ ΠΎΠ±ΡƒΡ‡Π΅Π½ΠΈΡŽ ΠΈΠ½Π²Π°Π»ΠΈΠ΄ΠΎΠ² ΠΈ Π»ΠΈΡ† с ΠΎΠ³Ρ€Π°Π½ΠΈΡ‡Π΅Π½Π½Ρ‹ΠΌΠΈ возмоТностями Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΡ, ΠΈ Π΄Π°ΡŽΡ‚ΡΡ Ρ€Π΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°Ρ†ΠΈΠΈ для развития ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Ρ… ΠΊΠΎΠΌΠΏΠ΅Ρ‚Π΅Π½Ρ†ΠΈ

    Medical and social characteristics of children with tuberculosis in conditions of social insufficiency in the Irkutsk region

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    Background. In cases of tuberculosis in children, contacts with patients with drug-resistant forms are often detected. Treatment and prevention of the disease is based on these data and adherence to treatment. Aims. To analyze the social status of the family of children with tuberculosis, clinical forms and drug resistance of MBT in patients who are sources of infection in the outbreak for adequate planning of preventive treatment of contact and treatment of children with tuberculosis. Materials and methods. The study involved 150 children with tuberculosis treated in a hospital in 2009-2012 and 142 children - in 2015-2017. We studied social factors and drug resistance of Mycobacterium tuberculosis in adult patients - sources to child transmission. Drug resistance of MBT cultures was determined by LΓΆwenstein - Jensen medium and automated system BACTEC MGIT 960. Results. 50.0 % of children with tuberculosis are patients of preschool age, 33.0 % of children aged under 3 years. From 2009-2012 to 2015-2017 the proportion of socially disadvantaged families fell from 68.0 % to 45.1 %. At the same time the proportion of children with tuberculosis, contracted from a known contact decreased from 70.0 % to 57.0 %. Often children get infected from mother or from several close relatives (mother, father, grandfather, grandmother), TB patients source of infection of children are often diagnosed with infiltrative (21.9-38.3 %) and fibro-cavernous tuberculosis (17.0-21.0 %). To 2015-2017 multi-drug resistance in the nidi was recorded at 52.2 %. The development of tuberculosis in children was facilitated by the defects of preventative measures: absence of BCG vaccination (from 9.0 to 14.0 % of children), the absence of preventive treatment (55.3-67.5 %)

    The effects of innovative changes influence on social and economic processes of the region development

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    Development of strategy of social and economic development of the Voronezh region till 2035 requires the careful analysis of a condition of all activities of the region, their interaction and interference. The special role in this process belongs to the higher school as the engine of knowledge, information and innovations. In case of all conservatism of an education system its task not only to give estimates and forecasts of the future, but also to serve as a leader of changes in all industries. The models realizing these tasks are a possibility of receipt of the effective instrument of increase in innovation of potential of economy of the region, forming of the environment which is adequately reflecting scientific and technical and economic challenges of modern realities and also developments of processes and technologies of transition of economy of the region to the principles of digital economy. Direct task of the higher school are increase in the amount of knowledge which is saved up by society, handling and transformation of information to knowledge, generation of new information and new knowledge, forming of the competitive specialist. In article approaches to an impact assessment of changes in the higher school on processes of social and economic development of the region, to classification of straight lines and side effects (spillover-effects) in the conditions of development of programs of a strategic development of the region are considered, the model of development of the higher school taking into account spillover-effect based on the principles of digital economy is offered. For the purpose of an impact assessment of changes in the higher school on processes of social and economic development in the region the task is set to analyse influence of various factors at each other, and also on basic factors of economic growth of the region

    ROLE OF SYSTEMATIC INFLAMMATION IN THE DEVELOPMENT OF COMORBIDITY IN CASE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

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    Often local inflammation develops into systemic one with total inflammatory response of endotheliocytes, plasma and cellular blood factors, connective tissue, and at the final stages it is manifested through microcirculatory disorders in vital organs and tissues. At present two aspects are being investigated related to systemic inflammation in chronic obstructive pulmonary disease (COPD). Firstly, it is the evaluation of inflammatory load through testing the level of inflammation markers in blood. Secondly, now it is generally recognized that a number of typical extrapulmonary disorders and concurrent diseases develops in COPD patients. Regardless of these general pathogenic mechanisms, the one thing is clear: cardiovascular diseases, body weight loss, osteoporosis and a number of other extrapulmonary manifestations of COPD are related to systematic inflammatory response

    ΠžΡ†Π΅Π½ΠΊΠ° Π΄ΠΎΠ· облучСния Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ² ΠΈ ΠΈΡ… ΠΏΡ€Π΅Π΄ΡˆΠ΅ΡΡ‚Π²Π΅Π½Π½ΠΈΠΊΠΎΠ² ΠΏΡ€ΠΈ ΠΏΠ΅Ρ€ΠΎΡ€Π°Π»ΡŒΠ½ΠΎΠΌ поступлСнии стронция-89,90

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    In radiobiology circulating T-lymphocytes are used as β€œnatural biodosimeters” since the frequency of chromosomal aberrations that occur in them after radiation exposure is proportional to the accumulated dose. In addition, stable chromosomal aberrations (translocations) are detected in them years and decades after radiation exposure. Estimation of doses to circulating lymphocytes requires consideration of two dose components: the dose accumulated by the lymphocyte precursors (progenitors) in the red bone marrow; and dose accumulated by the lymphocytes in the lymphoid organs/tissues during circulation. A recently created model of T-lymphocyte exposure takes into account all these dose components, as well as the age-dependent dynamics of T-lymphocytes. The use of a model approach is especially important in assessing doses from osteotropic beta emitters (89,90Sr). They accumulate in the bone and locally expose predominately bone marrow. The dose to other lymphoid organs and tissues is much lower. The objective of this study is to evaluate the conversion factors from ingested 89,90Sr to the cumulative dose to circulating T-lymphocytes and their progenitors (DCL). For calculations, the previously developed model of T-lymphocyte exposure and new dose coefficients for the red bone marrow, estimated on the basis of a sex-and-age-dependent biokinetic model and a new dosimetric model of the human skeleton were used. As a result, the DCL values were evaluated for the first time. The age at the time of 89,90Sr intake varied from a newborn to 35 years, the age of T-lymphocyte examination (blood sampling age) was up to 75 years. The maximum values of DCL for both 90Sr and 89Sr were typical of children in the first years of life. It has been shown that doses to circulating T-lymphocytes from these radionuclides are lower than those to bone marrow, but are significantly higher than doses to other lymphoid tissues. The effect of sex on DCL is manifested for children 10 years of age and older. The area of DCL application covers the population of radioactively contaminated territories (the Urals region, the zone of the Chernobyl accident), as well as personnel of the nuclear industry enterprises.Π¦ΠΈΡ€ΠΊΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠ΅ Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚Ρ‹ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΡŽΡ‚ΡΡ Π² Ρ€Π°Π΄ΠΈΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΊΠ°ΠΊ «СстСствСнныС Π±ΠΈΠΎΠ΄ΠΎΠ·ΠΈΠΌΠ΅Ρ‚Ρ€Ρ‹Β», ΠΏΠΎΡΠΊΠΎΠ»ΡŒΠΊΡƒ частота хромосомных Π°Π±Π΅Ρ€Ρ€Π°Ρ†ΠΈΠΉ, Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡŽΡ‰ΠΈΡ… Π² Π½ΠΈΡ… послС облучСния, ΠΏΡ€ΠΎΠΏΠΎΡ€Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Π° Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅. Π‘ΠΎΠ»Π΅Π΅ Ρ‚ΠΎΠ³ΠΎ, ΡΡ‚Π°Π±ΠΈΠ»ΡŒΠ½Ρ‹Π΅ хромосомныС Π°Π±Π΅Ρ€Ρ€Π°Ρ†ΠΈΠΈ (транслокации) ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠΈΠ²Π°ΡŽΡ‚ΡΡ Π² Π½ΠΈΡ… спустя Π³ΠΎΠ΄Ρ‹ ΠΈ дСсятилСтия послС облучСния. ΠžΡ†Π΅Π½ΠΊΠ° Π΄ΠΎΠ· Π½Π° Ρ†ΠΈΡ€ΠΊΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠ΅ Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚Ρ‹ Ρ‚Ρ€Π΅Π±ΡƒΠ΅Ρ‚ ΡƒΡ‡Π΅Ρ‚Π° 2 ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚ΠΎΠ²: Π΄ΠΎΠ·Ρ‹, ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½ΠΎΠΉ ΠΏΡ€Π΅Π΄ΡˆΠ΅ΡΡ‚Π²Π΅Π½Π½ΠΈΠΊΠ°ΠΌΠΈ (ΠΏΡ€ΠΎΠ³Π΅Π½ΠΈΡ‚ΠΎΡ€Π°ΠΌΠΈ) Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ² Π² красном костном ΠΌΠΎΠ·Π³Π΅; Π΄ΠΎΠ·Ρ‹, ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½ΠΎΠΉ Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚Π°ΠΌΠΈ Π² Π»ΠΈΠΌΡ„ΠΎΠΈΠ΄Π½Ρ‹Ρ… ΠΎΡ€Π³Π°Π½Π°Ρ…/тканях ΠΏΡ€ΠΈ циркуляции. НСдавно созданная модСль облучСния Ρ†ΠΈΡ€ΠΊΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ… Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ² ΡƒΡ‡ΠΈΡ‚Ρ‹Π²Π°Π΅Ρ‚ всС эти ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚Ρ‹, Π° Ρ‚Π°ΠΊΠΆΠ΅ возрастныС особСнности Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ². ОсобСнно Π²Π°ΠΆΠ½ΠΎ ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ модСльного ΠΏΠΎΠ΄Ρ…ΠΎΠ΄Π° ΠΏΡ€ΠΈ ΠΎΡ†Π΅Π½ΠΊΠ΅ Π΄ΠΎΠ· ΠΎΡ‚ остСотропных Π±Π΅Ρ‚Π°-ΠΈΠ·Π»ΡƒΡ‡Π°Ρ‚Π΅Π»Π΅ΠΉ (89,90Sr). ПослС попадания Π² ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌ ΠΎΠ½ΠΈ Π½Π°ΠΊΠ°ΠΏΠ»ΠΈΠ²Π°ΡŽΡ‚ΡΡ Π² кости ΠΈ практичСски локально ΠΎΠ±Π»ΡƒΡ‡Π°ΡŽΡ‚ костный ΠΌΠΎΠ·Π³, Ρ‚Π°ΠΊ Ρ‡Ρ‚ΠΎ Π΄ΠΎΠ·Π° Π½Π° Π΄Ρ€ΡƒΠ³ΠΈΠ΅ Π»ΠΈΠΌΡ„ΠΎΠΈΠ΄Π½Ρ‹Π΅ ΠΎΡ€Π³Π°Π½Ρ‹ ΠΈ Ρ‚ΠΊΠ°Π½ΠΈ оказываСтся сущСствСнно Π½ΠΈΠΆΠ΅. ЦСлью Π΄Π°Π½Π½ΠΎΠ³ΠΎ исслСдования являСтся ΠΎΡ†Π΅Π½ΠΊΠ° коэффициСнтов ΠΏΠ΅Ρ€Π΅Ρ…ΠΎΠ΄Π° ΠΎΡ‚ ΠΏΠ΅Ρ€ΠΎΡ€Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ поступлСния 89,90Sr ΠΊ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅ Π½Π° Ρ†ΠΈΡ€ΠΊΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠ΅ Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚Ρ‹ ΠΈ ΠΈΡ… ΠΏΡ€Π΅Π΄ΡˆΠ΅ΡΡ‚Π²Π΅Π½Π½ΠΈΠΊΠΎΠ² (Π”ΠšL). Для расчСтов использовали Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½Π½ΡƒΡŽ Ρ€Π°Π½Π΅Π΅ модСль облучСния Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ² ΠΈ Π½ΠΎΠ²Ρ‹Π΅ Π΄ΠΎΠ·ΠΎΠ²Ρ‹Π΅ коэффициСнты для красного костного ΠΌΠΎΠ·Π³Π°, ΠΎΡ†Π΅Π½Π΅Π½Π½Ρ‹Π΅ Π½Π° основС половозрастной биокинСтичСской ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΈ Π½ΠΎΠ²ΠΎΠΉ дозимСтричСской ΠΌΠΎΠ΄Π΅Π»ΠΈ скСлСта Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ ΠΏΡ€ΠΎΠ΄Π΅Π»Π°Π½Π½ΠΎΠΉ Ρ€Π°Π±ΠΎΡ‚Ρ‹ Π²ΠΏΠ΅Ρ€Π²Ρ‹Π΅ Π±Ρ‹Π»ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Ρ‹ значСния Π”ΠšL. Возраст Π½Π° ΠΌΠΎΠΌΠ΅Π½Ρ‚ поступлСния 89,90Sr Π²Π°Ρ€ΡŒΠΈΡ€ΠΎΠ²Π°Π» ΠΎΡ‚ Π½ΠΎΠ²ΠΎΡ€ΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠ³ΠΎ Π΄ΠΎ 35 Π»Π΅Ρ‚, возраст обслСдования Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ² (возраст Π·Π°Π±ΠΎΡ€Π° ΠΊΡ€ΠΎΠ²ΠΈ) – Π΄ΠΎ 75 Π»Π΅Ρ‚. ΠœΠ°ΠΊΡΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹Π΅ значСния Π΄ΠΎΠ·ΠΎΠ²Ρ‹Ρ… коэффициСнтов, ΠΊΠ°ΠΊ для 90Sr, Ρ‚Π°ΠΊ ΠΈ для 89Sr, Π±Ρ‹Π»ΠΈ Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π½Ρ‹ для Π΄Π΅Ρ‚Π΅ΠΉ ΠΏΠ΅Ρ€Π²Ρ‹Ρ… Π»Π΅Ρ‚ ΠΆΠΈΠ·Π½ΠΈ. Π‘Ρ‹Π»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ Π΄ΠΎΠ·Ρ‹ Π½Π° Ρ†ΠΈΡ€ΠΊΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠ΅ Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚Ρ‹ ΠΎΠΊΠ°Π·Ρ‹Π²Π°ΡŽΡ‚ΡΡ Π½ΠΈΠΆΠ΅, Ρ‡Π΅ΠΌ Π΄ΠΎΠ·Ρ‹ Π½Π° ККМ ΠΎΡ‚ этих Ρ€Π°Π΄ΠΈΠΎΠ½ΡƒΠΊΠ»ΠΈΠ΄ΠΎΠ², Π½ΠΎ сущСствСнно Π²Ρ‹ΡˆΠ΅, Ρ‡Π΅ΠΌ Π΄ΠΎΠ·Ρ‹ Π½Π° Π΄Ρ€ΡƒΠ³ΠΈΠ΅ Π»ΠΈΠΌΡ„ΠΎΠΈΠ΄Π½Ρ‹Π΅ Ρ‚ΠΊΠ°Π½ΠΈ. ВлияниС ΠΏΠΎΠ»Π° Π½Π° Π”ΠšL Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½ΠΎ для Π΄Π΅Ρ‚Π΅ΠΉ 10 Π»Π΅Ρ‚ ΠΈ ΡΡ‚Π°Ρ€ΡˆΠ΅. ΠžΠ±Π»Π°ΡΡ‚ΡŒ примСнСния Π”ΠšL ΠΎΡ…Π²Π°Ρ‚Ρ‹Π²Π°Π΅Ρ‚ Ρ€Π°Π±ΠΎΡ‚Π½ΠΈΠΊΠΎΠ² прСдприятий Π°Ρ‚ΠΎΠΌΠ½ΠΎΠΉ ΠΏΡ€ΠΎΠΌΡ‹ΡˆΠ»Π΅Π½Π½ΠΎΡΡ‚ΠΈ, Π° Ρ‚Π°ΠΊΠΆΠ΅ насСлСниС Ρ€Π°Π΄ΠΈΠΎΠ°ΠΊΡ‚ΠΈΠ²Π½ΠΎ загрязнСнных Ρ‚Π΅Ρ€Ρ€ΠΈΡ‚ΠΎΡ€ΠΈΠΉ (Π£Ρ€Π°Π»ΡŒΡΠΊΠΈΠΉ Ρ€Π΅Π³ΠΈΠΎΠ½, Π·ΠΎΠ½Π° Π§Π΅Ρ€Π½ΠΎΠ±Ρ‹Π»ΡŒΡΠΊΠΎΠΉ Π°Π²Π°Ρ€ΠΈΠΈ)

    ANALYSIS OF THE RESULTS OF SURGICAL PROCEDURES ADVISABLE FOR CHRONIC PANCREATITIS WITH THE PREDOMINANT LESION OF THE PANCREATIC HEAD

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    Recently, studies comparing various variants of operations to establish the optimal method of surgical treatmentΒ for chronic pancreatitis with pancreatic head lesions from the point of view of evidence-based medicine have beenΒ carried out in the world. However, these comparative studies do not take into account differences in the clinical andΒ morphological forms of the disease, in particular, chronic pancreatitis with a predominant and isolated lesion of the head.Β Subtotal resection of the pancreatic head with proximal pancreatojejunostomy, suitable for an isolated lesion of the head,Β does not solve all the problems of chronic pancreatitis with a predominant lesion of the head. In this case, the violationΒ of the outflow of pancreatic juice along the pathologically changed main pancreatic duct from the left half of the glandΒ is not eliminated. It is impossible to unambiguously support the hypothesis of the feasibility of performing subtotalΒ resection of the pancreatic head with proximal pancreatojejunostomy in chronic pancreatitis with a predominant lesionΒ of the head with a uniformly expanded main pancreatic duct. With this form of chronic pancreatitis, cicatricial stricturesΒ can form in the main pancreatic duct, which can lead to ductal hypertension and serve as an indication for reoperation.Β The feasibility of using Beger operation in chronic pancreatitis with a predominant lesion of the head is doubtful, sinceΒ the intersection of the isthmus and the need for a T-shaped longitudinal pancreatojejunostomy makes this interventionΒ technically difficult and unsafe. Based on the studies performed, it is impossible to say with certainty about the reliableΒ advantages of one type of operations over another. To obtain reliable results, it’s necessary to conduct evidence-basedΒ studies comparing subtotal resection of the pancreatic head with longitudinal pancreatojejunostomy with other typesΒ of interventions only for chronic pancreatitis with a predominant head lesion, excluding from the study patients withΒ chronic pancreatitis with isolated head lesion

    ΠΠ΅ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Π½ΠΎΡΡ‚ΡŒ ΠΎΡ†Π΅Π½ΠΊΠΈ Π΄ΠΎΠ· Π² костном ΠΌΠΎΠ·Π³Π΅ ΠΎΡ‚ 89,90Sr ΠΈΠ·-Π·Π° измСнчивости химичСского состава ΠΈ плотности кости

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    Dosimetric modeling of radiation transport in skeletal bone tissues using computational phantoms provides the doses of internal exposure to active marrow. Computational phantoms of ICRP are created for reference people with anatomical and physiological characteristics typical of an average individual. The doses calculated with such phantoms will correspond to certain population-average values. Individual variability will introduce a stochastic component of uncertainty into the dose estimation. The objective of this study is to assess the influence of variability of chemical composition and bone density on the results of dosimetric modeling. The phantoms are represented by simple geometry figures filled with trabecular structures and bone marrow and covered with a cortical layer. Radiation transport was simulated using the Monte Carlo method. The dose factors to convert the radionuclide activity concentration to absorbed dose rates in active marrow were calculated assuming uniform radionuclide distribution in the volume of the trabecular and cortical bone. As a result of the numerical experiments, it has been shown that variations in chemical composition do not introduce an error of more than Β± 4% into dosimetric modeling. The effect of bone density on active marrow dose formation depends on the size of a phantom. For computational phantoms with linear dimensions exceeding two electron free path lengths (~ 0.44 cm), variability of bone density within Β± 3% leads to a similar relative uncertainty of the dose conversion factor. However, for smaller phantoms, bone density variability leads to uncertainties of 6% or 13% for a source deposited in the trabecular or cortical bone, respectively. The results obtained will be used to assess the uncertainty of bone marrow dosimetry, taking into account the uncertainty of all parameters including the variability of morphometric characteristics of bones, the variability of the active marrow distribution in skeletal sites, as well as the uncertainties introduced by model approximations.Для расчСта Π΄ΠΎΠ· Π²Π½ΡƒΡ‚Ρ€Π΅Π½Π½Π΅Π³ΠΎ облучСния красного костного ΠΌΠΎΠ·Π³Π° примСняСтся ΠΌΠΎΠ΄Π΅Π»ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ пСрСноса ΠΈΠ·Π»ΡƒΡ‡Π΅Π½ΠΈΠΉ Π² тканях костСй скСлСта с использованиСм Π²Ρ‹Ρ‡ΠΈΡΠ»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… Ρ„Π°Π½Ρ‚ΠΎΠΌΠΎΠ². Π’Ρ‹Ρ‡ΠΈΡΠ»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ Ρ„Π°Π½Ρ‚ΠΎΠΌΡ‹ ΠœΠšΠ Π— созданы для стандартного Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° с анатомичСскими характСристиками, Ρ‚ΠΈΠΏΠΈΡ‡Π½Ρ‹ΠΌΠΈ для срСднСстатистичСского ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΡƒΠΌΠ°. Π”ΠΎΠ·Ρ‹, рассчитываСмыС Π½Π° основС Ρ‚Π°ΠΊΠΈΡ… Ρ„Π°Π½Ρ‚ΠΎΠΌΠΎΠ², Π±ΡƒΠ΄ΡƒΡ‚ ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΠΎΠ²Π°Ρ‚ΡŒ Π½Π΅ΠΊΠΈΠΌ срСднСпопуляционным, Π° ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½Π°Ρ ΠΈΠ·ΠΌΠ΅Π½Ρ‡ΠΈΠ²ΠΎΡΡ‚ΡŒ Π±ΡƒΠ΄Π΅Ρ‚ Π²Π½ΠΎΡΠΈΡ‚ΡŒ ΡΡ‚ΠΎΡ…Π°ΡΡ‚ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚Ρƒ нСопрСдСлСнности Π² ΠΎΡ†Π΅Π½ΠΊΡƒ Π΄ΠΎΠ·. ЦСлью настоящСй Ρ€Π°Π±ΠΎΡ‚Ρ‹ являСтся ΠΎΡ†Π΅Π½ΠΊΠ° влияния Π²Π°Ρ€ΠΈΠ°Π±Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ химичСского состава ΠΈ плотности кости Π½Π° Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ дозимСтричСского модСлирования. Использовали Π²Ρ‹Ρ‡ΠΈΡΠ»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ Ρ„Π°Π½Ρ‚ΠΎΠΌΡ‹ Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚ΠΎΠ² костСй скСлСта, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ прСдставлСны простыми гСомСтричСскими Ρ„ΠΈΠ³ΡƒΡ€Π°ΠΌΠΈ, Π·Π°ΠΏΠΎΠ»Π½Π΅Π½Π½Ρ‹ΠΌΠΈ трабСкулярными структурами ΠΈ костным ΠΌΠΎΠ·Π³ΠΎΠΌ ΠΈ ΠΏΠΎΠΊΡ€Ρ‹Ρ‚Ρ‹ΠΌΠΈ снаруТи ΠΊΠΎΡ€Ρ‚ΠΈΠΊΠ°Π»ΡŒΠ½Ρ‹ΠΌ слоСм. ΠŸΠ΅Ρ€Π΅Π½ΠΎΡ ΠΈΠ·Π»ΡƒΡ‡Π΅Π½ΠΈΠΉ имитировался ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ ΠœΠΎΠ½Ρ‚Π΅-ΠšΠ°Ρ€Π»ΠΎ. Π Π°ΡΡΡ‡ΠΈΡ‚Ρ‹Π²Π°Π»ΠΈΡΡŒ коэффициСнты ΠΏΠ΅Ρ€Π΅Ρ…ΠΎΠ΄Π° ΠΎΡ‚ ΡƒΠ΄Π΅Π»ΡŒΠ½ΠΎΠΉ активности Ρ€Π°Π΄ΠΈΠΎΠ½ΡƒΠΊΠ»ΠΈΠ΄ΠΎΠ² ΠΊ мощности ΠΏΠΎΠ³Π»ΠΎΡ‰Π΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Ρ‹ Π² красном костном ΠΌΠΎΠ·Π³Π΅ ΠΏΡ€ΠΈ ΠΈΡ… Ρ€Π°Π²Π½ΠΎΠΌΠ΅Ρ€Π½ΠΎΠΌ распрСдСлСнии Π² объСмС трабСкулярной Π»ΠΈΠ±ΠΎ ΠΊΠΎΡ€Ρ‚ΠΈΠΊΠ°Π»ΡŒΠ½ΠΎΠΉ кости. На основС расчСтов ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Ρ‹ коэффициСнты, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡŽΡ‰ΠΈΠ΅ ΠΊΠΎΠ½Π²Π΅Ρ€Ρ‚ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ ΡƒΠ΄Π΅Π»ΡŒΠ½ΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ Ρ€Π°Π΄ΠΈΠΎΠ½ΡƒΠΊΠ»ΠΈΠ΄Π° Π² Π΅Π΄ΠΈΠ½ΠΈΡ†Ρ‹ мощности ΠΏΠΎΠ³Π»ΠΎΡ‰Π΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Ρ‹ Π² красном костном ΠΌΠΎΠ·Π³Π΅. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ числСнных экспСримСнтов Π±Ρ‹Π»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ Π²Π°Ρ€ΠΈΠ°Ρ†ΠΈΠΈ химичСского состава Π² ΠΏΡ€Π΅Π΄Π΅Π»Π°Ρ… физиологичСских ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ Π½Π΅ вносят Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ ΠΏΠΎΠ³Ρ€Π΅ΡˆΠ½ΠΎΡΡ‚ΠΈ большС Β±4% Π² Π·Π½Π°Ρ‡Π΅Π½ΠΈΠ΅ Π΄ΠΎΠ· Π½Π° красный костный ΠΌΠΎΠ·Π³. ВлияниС плотности костной Ρ‚ΠΊΠ°Π½ΠΈ Π½Π° Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΎΠ·Ρ‹ Π² красном костном ΠΌΠΎΠ·Π³Π΅ зависит ΠΎΡ‚ Ρ€Π°Π·ΠΌΠ΅Ρ€Π° Ρ„Π°Π½Ρ‚ΠΎΠΌΠ°. Для Ρ„Π°Π½Ρ‚ΠΎΠΌΠΎΠ², Ρ‡ΡŒΠΈ Π»ΠΈΠ½Π΅ΠΉΠ½Ρ‹Π΅ Ρ€Π°Π·ΠΌΠ΅Ρ€Ρ‹ ΠΏΡ€Π΅Π²Ρ‹ΡˆΠ°ΡŽΡ‚ Π΄Π²Π΅ Π΄Π»ΠΈΠ½Ρ‹ свободного ΠΏΡ€ΠΎΠ±Π΅Π³Π° элСктронов (~ 0,44 см), Π²Π°Ρ€ΠΈΠ°Π±Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ плотности костной Ρ‚ΠΊΠ°Π½ΠΈ Π² ΠΏΡ€Π΅Π΄Π΅Π»Π°Ρ… Β±3% ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ Π°Π½Π°Π»ΠΎΠ³ΠΈΡ‡Π½ΠΎΠΉ ΠΏΠΎ Π²Π΅Π»ΠΈΡ‡ΠΈΠ½Π΅ ΠΎΡ‚Π½ΠΎΡΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ нСопрСдСлСнности коэффициСнтов ΠΏΠ΅Ρ€Π΅Ρ…ΠΎΠ΄Π°. Однако для Ρ„Π°Π½Ρ‚ΠΎΠΌΠΎΠ² ΠΌΠ΅Π½ΡŒΡˆΠΈΡ… Ρ€Π°Π·ΠΌΠ΅Ρ€ΠΎΠ² Π²Π°Ρ€ΠΈΠ°Π±Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ плотности костной Ρ‚ΠΊΠ°Π½ΠΈ ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ нСопрСдСлСнностям этих коэффициСнтов Ρ€Π°Π²Π½Ρ‹ΠΌ 6% ΠΈΠ»ΠΈ 13%, Ссли источник Π΄Π΅ΠΏΠΎΠ½ΠΈΡ€ΠΎΠ²Π°Π½ Π² трабСкулярной ΠΈΠ»ΠΈ ΠΊΠΎΡ€Ρ‚ΠΈΠΊΠ°Π»ΡŒΠ½ΠΎΠΉ кости соотвСтствСнно. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Π΅ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ Π±ΡƒΠ΄ΡƒΡ‚ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Π½Ρ‹ ΠΏΡ€ΠΈ ΠΎΡ†Π΅Π½ΠΊΠ΅ суммарной нСопрСдСлСнности ΠΏΠΎΠ³Π»ΠΎΡ‰Π΅Π½Π½Ρ‹Ρ… Π΄ΠΎΠ· красным костным ΠΌΠΎΠ·Π³ΠΎΠΌ с ΡƒΡ‡Π΅Ρ‚ΠΎΠΌ нСопрСдСлСнности всСх ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΠ΅ΠΌΡ‹Ρ… ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΎΠ², Π²ΠΊΠ»ΡŽΡ‡Π°Ρ Π²Π°Ρ€ΠΈΠ°Π±Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ морфомСтричСских характСристик костСй, Π²Π°Ρ€ΠΈΠ°Π±Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ распрСдСлСния красного костного ΠΌΠΎΠ·Π³Π° ΠΌΠ΅ΠΆΠ΄Ρƒ структурами скСлСта, Π° Ρ‚Π°ΠΊΠΆΠ΅ Π½Π΅ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Π½ΠΎΡΡ‚ΡŒ, ΠΏΡ€ΠΈΠ²Π½ΠΎΡΠΈΠΌΡƒΡŽ ΠΌΠΎΠ΄Π΅Π»ΡŒΠ½Ρ‹ΠΌΠΈ приблиТСниями

    ΠžΡ†Π΅Π½ΠΊΠ° Π΄ΠΎΠ· облучСния Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ² ΠΏΡ€ΠΈ ΠΏΠ΅Ρ€ΠΎΡ€Π°Π»ΡŒΠ½ΠΎΠΌ поступлСнии Ρ€Π°Π΄ΠΈΠΎΠ½ΡƒΠΊΠ»ΠΈΠ΄ΠΎΠ² Ρ€Π°Π·Π»ΠΈΡ‡Π½ΠΎΠΉ тропности

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    Assessment of the lymphocyte doses is relevant for solving a number of radiobiological problems, including the risk assessment of hemoblastosis (leukemia, multiple myeloma, lymphoma etc.), as well as the use of circulating lymphocytes as β€œnatural biodosimeters”. The latter is because the frequency of chromosomal aberrations occurring in lymphocytes following radiation exposure is proportional to the accumulated dose. Assessment of doses to the circulating lymphocytes requires due account of: first, the dose accumulated by the lymphocyte progenitors in the red bone marrow; and second, the dose accumulated during lymphocyte circulation through lymphoid organs. The models presented by International Commission on Radiological Protection (ICRP-67, ICRP-100) allow calculating the dose for specific lymphoid organs based on known level of radionuclide intakes. A recently developed model of circulating T-lymphocyte irradiation takes into account all sources of exposure and age-related dynamics of T-lymphocytes: (1) exposure of lymphocyte progenitors in red bone marrow: (2) exposure of T-lymphocytes in the lymphoid organs, taking into account the proportion of resident lymphocytes and the residence time of circulating lymphocytes in the specific lymphoid organs. The objective of the study is to assess the dose coefficients allowing for the transition from the ingestion ofΒ 141,144Ce,Β 95Zr,Β 103,106Ru,Β 95Nb to the doses accumulated in circulating T-lymphocytes. For calculations, we used the dose coefficients from ICRP publications for specific lymphoid organs, as well as published data on the residence time of circulating lymphocytes in lymphoid organs and tissues. As a result, it was shown that the doses in circulating T-lymphocytes are higher than those in the red bone marrow, but lower than the doses to the colon wall. The dose coefficients were age dependent; the maximum values were typical for newborns. The obtained dose coefficients forΒ 141,144Ce,Β 95Zr,Β 95Nb andΒ 103,106Ru can be used to estimate the tissue and organ doses based on data on the frequency of chromosomal aberrations in peripheral blood lymphocytes.ΠžΡ†Π΅Π½ΠΊΠ° Π΄ΠΎΠ· Π½Π° Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚Ρ‹ Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Π° Π² свСтС Ρ€Π΅ΡˆΠ΅Π½ΠΈΡ ряда радиобиологичСских ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌ, Π²ΠΊΠ»ΡŽΡ‡Π°Ρ ΠΎΡ†Π΅Π½ΠΊΡƒ риска Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… гСмобластозов (Π»Π΅ΠΉΠΊΠΎΠ·, мноТСствСнная ΠΌΠΈΠ΅Π»ΠΎΠΌΠ°, Π»ΠΈΠΌΡ„ΠΎΠΌΠ° ΠΈ Π΄Ρ€.), Π° Ρ‚Π°ΠΊΠΆΠ΅ использования Ρ†ΠΈΡ€ΠΊΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ… Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ² Π² качСствС «СстСствСнных Π±ΠΈΠΎΠ΄ΠΎΠ·ΠΈΠΌΠ΅Ρ‚Ρ€ΠΎΠ²Β». ПослСднСС связано с Ρ‚Π΅ΠΌ, Ρ‡Ρ‚ΠΎ частота хромосомных Π°Π±Π΅Ρ€Ρ€Π°Ρ†ΠΈΠΉ, Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡŽΡ‰ΠΈΡ… Π² Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚Π°Ρ… послС Π»ΡƒΡ‡Π΅Π²ΠΎΠ³ΠΎ воздСйствия, ΠΏΡ€ΠΎΠΏΠΎΡ€Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Π° Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅. ΠžΡ†Π΅Π½ΠΊΠ° Π΄ΠΎΠ· Π½Π° Ρ†ΠΈΡ€ΠΊΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠ΅ Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚Ρ‹ Ρ‚Ρ€Π΅Π±ΡƒΠ΅Ρ‚ ΡƒΡ‡Π΅Ρ‚Π° Π΄Π²ΡƒΡ… Ρ„Π°ΠΊΡ‚ΠΎΡ€ΠΎΠ²: Π²ΠΎ-ΠΏΠ΅Ρ€Π²Ρ‹Ρ…, Π΄ΠΎΠ·Ρ‹, ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½ΠΎΠΉ ΠΏΡ€Π΅Π΄ΡˆΠ΅ΡΡ‚Π²Π΅Π½Π½ΠΈΠΊΠ°ΠΌΠΈ (ΠΏΡ€ΠΎΠ³Π΅Π½ΠΈΡ‚ΠΎΡ€Π°ΠΌΠΈ) Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ² Π² красном костном ΠΌΠΎΠ·Π³Π΅; Π° Π²ΠΎ-Π²Ρ‚ΠΎΡ€Ρ‹Ρ…, Π΄ΠΎΠ·Ρ‹, ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½ΠΎΠΉ Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚Π°ΠΌΠΈ Π² Π»ΠΈΠΌΡ„ΠΎΠΈΠ΄Π½Ρ‹Ρ… ΠΎΡ€Π³Π°Π½Π°Ρ… ΠΏΡ€ΠΈ циркуляции. МодСли, прСдставлСнныС Π² публикациях ΠœΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½ΠΎΠΉ комиссии ΠΏΠΎ радиологичСской Π·Π°Ρ‰ΠΈΡ‚Π΅ (ICRP-67, ICRP-100), Π΄Π°ΡŽΡ‚ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ Ρ€Π°ΡΡΡ‡ΠΈΡ‚Π°Ρ‚ΡŒ Π΄ΠΎΠ·Ρƒ для ΠΊΠΎΠ½ΠΊΡ€Π΅Ρ‚Π½ΠΎΠ³ΠΎ Π»ΠΈΠΌΡ„ΠΎΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΡ€Π³Π°Π½Π° ΠΏΡ€ΠΈ извСстном ΡƒΡ€ΠΎΠ²Π½Π΅ поступлСния Ρ€Π°Π΄ΠΈΠΎΠ½ΡƒΠΊΠ»ΠΈΠ΄Π°. НСдавно созданная модСль облучСния Ρ†ΠΈΡ€ΠΊΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ… Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ² ΡƒΡ‡ΠΈΡ‚Ρ‹Π²Π°Π΅Ρ‚ всС слагаСмыС Π΄ΠΎΠ·Ρ‹ ΠΈ возрастныС особСнности Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ²: 1) ΠΎΠ±Π»ΡƒΡ‡Π΅Π½ΠΈΠ΅ ΠΏΡ€Π΅Π΄ΡˆΠ΅ΡΡ‚Π²Π΅Π½Π½ΠΈΠΊΠΎΠ² Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ² Π² красном костном ΠΌΠΎΠ·Π³Π΅; 2) ΠΎΠ±Π»ΡƒΡ‡Π΅Π½ΠΈΠ΅ Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ² Π² ΠΊΠ°ΠΆΠ΄ΠΎΠΌ Π»ΠΈΠΌΡ„ΠΎΠΈΠ΄Π½ΠΎΠΌ ΠΎΡ€Π³Π°Π½Π΅ с ΡƒΡ‡Π΅Ρ‚ΠΎΠΌ Π΄ΠΎΠ»ΠΈ Ρ€Π΅Π·ΠΈΠ΄Π΅Π½Ρ‚Π½Ρ‹Ρ… Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ², Π° Ρ‚Π°ΠΊΠΆΠ΅ Π²Ρ€Π΅ΠΌΠ΅Π½ΠΈ прСбывания Ρ‚Π°ΠΌ Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ². ЦСлью Π΄Π°Π½Π½ΠΎΠ³ΠΎ исслСдования являСтся ΠΎΡ†Π΅Π½ΠΊΠ° Π΄ΠΎΠ·ΠΎΠ²Ρ‹Ρ… коэффициСнтов, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡŽΡ‰ΠΈΡ… ΠΏΠ΅Ρ€Π΅ΠΉΡ‚ΠΈ ΠΎΡ‚ ΠΏΠ΅Ρ€ΠΎΡ€Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ поступлСния I4I,I44Ce, 95Zr, 103,106Ru, 95Nb ΠΊ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½Π½ΠΎΠΉ Π΄ΠΎΠ·Π΅ Π½Π° Ρ†ΠΈΡ€ΠΊΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠ΅ Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚Ρ‹. Для расчСтов использовались Π΄ΠΎΠ·ΠΎΠ²Ρ‹Π΅ коэффициСнты ΠΈΠ· ΠΏΡƒΠ±Π»ΠΈΠΊΠ°Ρ†ΠΈΠΉ ΠœΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½ΠΎΠΉ комиссии ΠΏΠΎ радиологичСской Π·Π°Ρ‰ΠΈΡ‚Π΅ для ΠΊΠΎΠ½ΠΊΡ€Π΅Ρ‚Π½Ρ‹Ρ… Π»ΠΈΠΌΡ„ΠΎΠΈΠ΄Π½Ρ‹Ρ… ΠΎΡ€Π³Π°Π½ΠΎΠ², Π° Ρ‚Π°ΠΊΠΆΠ΅ ΠΎΠΏΡƒΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½Π½Ρ‹Π΅ ΠΎΡ†Π΅Π½ΠΊΠΈ Π²Ρ€Π΅ΠΌΠ΅Π½ΠΈ, ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ΅ Ρ†ΠΈΡ€ΠΊΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠ΅ Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚Ρ‹ проводят Π² этих Π»ΠΈΠΌΡ„ΠΎΠΈΠ΄Π½Ρ‹Ρ… ΠΎΡ€Π³Π°Π½Π°Ρ… ΠΈ тканях. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ Π±Ρ‹Π»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ Π΄ΠΎΠ·Ρ‹ Π½Π° Ρ†ΠΈΡ€ΠΊΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠ΅ Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚Ρ‹ Π²Ρ‹ΡˆΠ΅, Ρ‡Π΅ΠΌ Π΄ΠΎΠ·Ρ‹ Π½Π° красный костный ΠΌΠΎΠ·Π³ ΠΎΡ‚ этих Ρ€Π°Π΄ΠΈΠΎΠ½ΡƒΠΊΠ»ΠΈΠ΄ΠΎΠ², Π½ΠΎ Π½ΠΈΠΆΠ΅, Ρ‡Π΅ΠΌ Π΄ΠΎΠ·Ρ‹ Π½Π° стСнку толстой кишки. РассчитанныС Π΄ΠΎΠ·ΠΎΠ²Ρ‹Π΅ коэффициСнты зависСли ΠΎΡ‚ возраста; ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹Π΅ значСния Π±Ρ‹Π»ΠΈ Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π½Ρ‹ для Π½ΠΎΠ²ΠΎΡ€ΠΎΠΆΠ΄Π΅Π½Π½Ρ‹Ρ…. Π”Π°Π½Π½Ρ‹Π΅ коэффициСнты для 141,144Ce, 95Zr, 95Nb ΠΈ I03,I06Ru ΠΌΠΎΠ³ΡƒΡ‚ Π±Ρ‹Ρ‚ΡŒ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Π½Ρ‹ для ΠΎΡ†Π΅Π½ΠΊΠΈ Π΄ΠΎΠ· Π½Π° ΠΎΡ€Π³Π°Π½Ρ‹ ΠΈ Ρ‚ΠΊΠ°Π½ΠΈ Π½Π° основС Π΄Π°Π½Π½Ρ‹Ρ… ΠΎ частотС хромосомных Π°Π±Π΅Ρ€Ρ€Π°Ρ†ΠΈΠΉ Π² Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚Π°Ρ… пСрифСричСской ΠΊΡ€ΠΎΠ²ΠΈ
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