Changes in Post-COVID Syndrome Manifestations and Bulbar Conjunctival Angioscopy Results in a Patient Undergoing Treatment after Mild COVID-19

Microcirculation dysfunction plays a significant role in the development of post-COVID syndrome caused by SARS-CoV-2. However, there have been no studies on changes in microcirculation parameters during pharmacotherapy in patients with post-COVID syndrome. To date, there are no consensus recommendations for the treatment of post-COVID syndrome in the Russian Federation.The aim of the study was to analyse the pattern of clinical manifestations of post-COVID syndrome and bulbar conjunctival angioscopy (BCA) results in a young patient undergoing treatment after mild COVID-19.Materials and methods: analysis of the clinical case of a patient who was followed up at the Therapeutic Ophthalmology Centre between February and September 2021. BCA was performed in a patient with post-COVID syndrome to compare quantitative and qualitative microcirculation parameters before and after the treatment.Results: the paper summarises clinical observation data on a 23-year-old female patient with post-COVID syndrome with mainly neuropsychiatric manifestations and a microcirculation dysfunction as determined by BCA. The patient received pharmacotherapy with meldonium, ethylmethylhydroxypyridine succinate, and meglumine sodium succinate.Conclusions: the prescribed pharmacotherapy led to a significant improvement in the patient’s condition (regression in neuropsychiatric symptoms) with simultaneous improvement of morphological and functional parameters assessed by BCA, which indicates an improvement in microcirculation processes and supports their role in post-COVID syndrome development. The obtained data suggest that the clinical picture of post-COVID syndrome is directly related to the severity of microcirculation dysfunction in various organs and tissues, and that BCA can be used for diagnosis and assessment of the syndrome’s severity, as well as for assessment of the treatment’s efficacy and safety

Ожирение и метаболические нарушения у больных хронической обструктивной болезнью легких: возможности фенотипирования

The aim of the study was to compare clinical and functional features and healthrelated quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD) regarding to comorbid obesity as a phenotypic sign. Methods. Patient classification was performed using Kmeans clustering analysis (MacQueen). It resulted in the classification of subjects into four clinical groups with marked differences in COPD symptoms.Results. Subjects with obesity had severe airflow limitation and dyspnoea, frequent exacerbations, severely impaired HRQoL, poor survival, decreased physical activity, insulin resistance and increased systemic inflammation.Conclusion. Thus, COPD with comorbid obesity could be considered as a distinct phenotype of COPD with severe symptoms.Целью исследования явилось изучение клиникофункциональных параметров и качества жизни (КЖ) больных хронической обструктивной болезнью легких (ХОБЛ) c сопутствующим ожирением и метаболическими нарушениями с оценкой возможности их фенотипирования. На основании кластерного анализа, проведенного по методу kсредних МакКуина, выделены 4 группы пациентов с отличительными особенностями течения ХОБЛ. Установлено, что наличие сопутствующего ожирения у больных ХОБЛ ассоциировано со значительным снижением легочной функции, переносимости физической нагрузки, показателей КЖ и выживаемости, частыми обострениями, развитием инсулинорезистентности и активацией системных воспалительных реакций. Предполагается, что клинический вариант ХОБЛ с сопутствующим ожирением целесообразно рассматривать в качестве отдельного фенотипа заболевания, характеризующегося тяжелым течением

Materials of the concluding conference of young scientists of MSUMS named after A.I. Evdokimov, 2013

Materials of the concluding conference of young scientists of MSUMS named after A.I. Evdokimov, 201

CLINICAL CASE CHURG-STRAUSS SYNDROME: DIFFICULTIES IN THE DIAGNOSIS, THERAPEUTIC TACTICS

Churg-Strauss  syndrome  is a  rare  autoimmune   disease  with  small-vessel  vasculitis. We report  a  case  of 60-year-old   man.  The presence  of hypereosinophilia, asthma,  sinusitis and extravascular eosinophil accumulation  led to the diagnosis of Churg-Strauss syndrome. The patient  was effectively treated with methylprednisolone, cyclophosphamide

Concluding proceedings of the young researchers' conference of the Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, 2013

Concluding proceedings of the young researchers' conference of the Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, 201

Chemistry for Sustainable Development 19 (2011) 173180 Liquid-Phase Dechlorination of Toxic Man-Made Products Using Nanodispersed Palladium Catalysts Sibunit

Abstract Studies concerning the liquid-phase catalytic reductive dechlorin ation of toxic man-made products using catalysts M/Sibunit (M = Ni, Pt, Pd) were performed. It has been demonstrated that the most pronounced activity is exhibited by catalysts based on palladium