ВНУТРІШНЬОПЕЧІНКОВИЙ ХОЛЕСТАЗ ВАГІТНИХ ПІСЛЯ ЗАСТОСУВАННЯ ДОПОМІЖНИХ РЕПРОДУКТИВНИХ ТЕХНОЛОГІЙ: КЛІНІЧНІ ОСОБЛИВОСТІ

80 pregnant women were examined after assisted reproductive technology (ART) programs: 40 women with manifestations of intrahepatic cholestasis of pregnant women (IHP) - the main group and 40 women without manifestations of IHP (comparison group).In the majority (62.5%) of patients after ART, the diagnosis of IHP established after 30 weeks of pregnancy. Some patients (27.5%) reported short-term episodes of IHP up to 24 weeks of gestation. In 17.5% of women, IHP had a severe course. Almost a third (27.5%) of women are over 35 years old. Women with IHP have a significantly higher frequency of allergies in the anamnesis (35.0%), liver pathology (20.0%) and diseases of the gastrointestinal tract (25.0%). In one third of women, IHP developed repeatedly, 42.5% of the main patients indicated a family history burdened with IHP. Almost a third of women (27.5% vs. 12.5%, p<0.05) had a history of polycystic ovary syndrome.The current pregnancy characterized by a high frequency of complications. A quarter of patients (25.0%) had early preeclampsia. In the second half of pregnancy, the threat of preterm birth noted in most women during the manifestation of IHP (60.0%). The incidence of fetal distress in women with IHP was almost 2 times higher than in patients without this complication (47.5% vs. 25.0%, respectively, p <0.05). The frequency of preeclampsia is also higher (40.0%).The vast majority of women in the main group were born by cesarean section (70.0%). Almost half of patients with IHP were premature (45.0%). A third of women (35.0%) had fetal distress in childbirth. In 27.5%, childbirth complicated by bleeding of more than 5% of body weight. The postpartum period was characterized by a 4-fold increase in the frequency of late bleeding (20.0% vs. 5.0%, p <0.05).One case of antenatal mortality noted in pregnant women after ART with IHP. Almost half of the children were born with asphyxia of varying severity (48.7%), with 10.3% diagnosed with severe asphyxia. One third of children were born with a body weight below 2500 g (30.8%). In 74.4% of newborns from mothers of the main group, various disorders of the period of early neonatal adaptation were noted, among which the most prominent were: RDS (35.9%), jaundice (43.6%) and gastrointestinal syndrome (30.8%). The 2-fold increased incidence of hemorrhagic syndrome (17.9%) is noteworthy.80 pregnant women were examined after assisted reproductive technology (ART) programs: 40 women with manifestations of intrahepatic cholestasis of pregnant women (IHP) - the main group and 40 women without manifestations of IHP (comparison group).In the majority (62.5%) of patients after ART, the diagnosis of IHP established after 30 weeks of pregnancy. Some patients (27.5%) reported short-term episodes of IHP up to 24 weeks of gestation. In 17.5% of women, IHP had a severe course. Almost a third (27.5%) of women are over 35 years old. Women with IHP have a significantly higher frequency of allergies in the anamnesis (35.0%), liver pathology (20.0%) and diseases of the gastrointestinal tract (25.0%). In one third of women, IHP developed repeatedly, 42.5% of the main patients indicated a family history burdened with IHP. Almost a third of women (27.5% vs. 12.5%, p<0.05) had a history of polycystic ovary syndrome.The current pregnancy characterized by a high frequency of complications. A quarter of patients (25.0%) had early preeclampsia. In the second half of pregnancy, the threat of preterm birth noted in most women during the manifestation of IHP (60.0%). The incidence of fetal distress in women with IHP was almost 2 times higher than in patients without this complication (47.5% vs. 25.0%, respectively, p <0.05). The frequency of preeclampsia is also higher (40.0%).The vast majority of women in the main group were born by cesarean section (70.0%). Almost half of patients with IHP were premature (45.0%). A third of women (35.0%) had fetal distress in childbirth. In 27.5%, childbirth complicated by bleeding of more than 5% of body weight. The postpartum period was characterized by a 4-fold increase in the frequency of late bleeding (20.0% vs. 5.0%, p <0.05).One case of antenatal mortality noted in pregnant women after ART with IHP. Almost half of the children were born with asphyxia of varying severity (48.7%), with 10.3% diagnosed with severe asphyxia. One third of children were born with a body weight below 2500 g (30.8%). In 74.4% of newborns from mothers of the main group, various disorders of the period of early neonatal adaptation were noted, among which the most prominent were: RDS (35.9%), jaundice (43.6%) and gastrointestinal syndrome (30.8%). The 2-fold increased incidence of hemorrhagic syndrome (17.9%) is noteworthy

Emergence of pseudogap from short-range spin-correlations in electron doped cuprates

Electron interactions are pivotal for defining the electronic structure of quantum materials. In particular, the strong electron Coulomb repulsion is considered the keystone for describing the emergence of exotic and/or ordered phases of quantum matter as disparate as high-temperature superconductivity and charge- or magnetic-order. However, a comprehensive understanding of fundamental electronic properties of quantum materials is often complicated by the appearance of an enigmatic partial suppression of low-energy electronic states, known as the pseudogap. Here we take advantage of ultrafast angle-resolved photoemission spectroscopy to unveil the temperature evolution of the low-energy density of states in the electron-doped cuprate Nd$_{\text{2-x}}$Ce$_{\text{x}}$CuO$_{\text{4}}$, an emblematic system where the pseudogap intertwines with magnetic degrees of freedom. By photoexciting the electronic system across the pseudogap onset temperature T*, we report the direct relation between the momentum-resolved pseudogap spectral features and the spin-correlation length with an unprecedented sensitivity. This transient approach, corroborated by mean field model calculations, allows us to establish the pseudogap in electron-doped cuprates as a precursor to the incipient antiferromagnetic order even when long-range antiferromagnetic correlations are not established, as in the case of optimal doping.Comment: 17 pages, 3 figure

Collapse of superconductivity in cuprates via ultrafast quenching of phase coherence

The possibility of driving phase transitions in low-density condensates through the loss of phase coherence alone has far-reaching implications for the study of quantum phases of matter. This has inspired the development of tools to control and explore the collective properties of condensate phases via phase fluctuations. Electrically-gated oxide interfaces, ultracold Fermi atoms, and cuprate superconductors, which are characterized by an intrinsically small phase-stiffness, are paradigmatic examples where these tools are having a dramatic impact. Here we use light pulses shorter than the internal thermalization time to drive and probe the phase fragility of the Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$ cuprate superconductor, completely melting the superconducting condensate without affecting the pairing strength. The resulting ultrafast dynamics of phase fluctuations and charge excitations are captured and disentangled by time-resolved photoemission spectroscopy. This work demonstrates the dominant role of phase coherence in the superconductor-to-normal state phase transition and offers a benchmark for non-equilibrium spectroscopic investigations of the cuprate phase diagram.Comment: 24 pages, 9 figures, Main Text and Supplementary Informatio

Cavity-enhanced high harmonic generation for XUV time-resolved ARPES

With its direct correspondence to electronic structure, angle-resolved photoemission spectroscopy (ARPES) is a ubiquitous tool for the study of solids. When extended to the temporal domain, time-resolved (TR)-ARPES offers the potential to move beyond equilibrium properties, exploring both the unoccupied electronic structure as well as its dynamical response under ultrafast perturbation. Historically, ultrafast extreme ultraviolet (XUV) sources employing high-order harmonic generation (HHG) have required compromises that make it challenging to achieve a high energy resolution - which is highly desirable for many TR-ARPES studies - while producing high photon energies and a high photon flux. We address this challenge by performing HHG inside a femtosecond enhancement cavity (fsEC), realizing a practical source for TR-ARPES that achieves a flux of over 10$^{11}$ photons/s delivered to the sample, operates over a range of 8-40 eV with a repetition rate of 60 MHz. This source enables TR-ARPES studies with a temporal and energy resolution of 190 fs and 22 meV, respectively. To characterize the system, we perform ARPES measurements of polycrystalline Au and MoTe$_2$, as well as TR-ARPES studies on graphite.Comment: 11 pages, 5 figure

Волоконно-оптический датчик идентификации жидкостей и определения концентрации растворов

Fiber-optic sensors for identifying liquids and determining the concentration of solutions have been studied with the possibility of using various types of single-mode optical fibers produced by industry and widely used in optical cables and telecommunications to create sensors for identifying liquids and determining the concentration of solutions. To identify liquids with different refractive indices and determine the concentration of substances dissolved in water, the peak value of the reflectograms of the optical fiber located at the interface between the optical fiber core and the environment can be used as an information parameter. The value of the information parameter depends on the refractive index of the liquid in which one end of the optical fiber is located. The parameters of fiber-optic sensors for identifying liquids and determining the concentration of solutions were studied by optical reflectometry in different wavelength ranges of optical radiation with a duration of reflectometer probe pulses from 25 to 300 ns. It has been established that the fiber-optic sensor can operate at any wavelength of optical radiation corresponding to the transparency windows of the optical loss spectrum of the optical fiber. The influence of the length of the optical fiber between the recording device and the place where the concentration of a liquid solution is determined using a fiber-optic sensor was studied. The possibility of creating a fiber-optic sensor for determining the concentration of the liquid solutions based on optical fibers has been demonstrated.Исследована возможность использования различных типов одномодовых оптических волокон, массово выпускаемых промышленностью и широко применяемых в оптических кабелях и телекоммуникациях, для создания волоконно-оптических датчиков идентификации жидкостей и определения концентрации растворов. Для идентификации жидкостей, имеющих разные показатели преломления, и определения концентрации растворенных в воде веществ в качестве информационного параметра можно использовать величину пика рефлектограмм оптического волокна, находящегося на границе раздела сердцевины оптического волокна и окружающей среды. Значение информационного параметра зависит от показателя преломления жидкости, в которой находится торец оптического волокна. Параметры волоконно-оптических датчиков идентификации жидкос тей и определения концентрации растворов исследованы методом оптической рефлектометрии в разных диапазонах длин волн оптического излучения при длительности зондирующих импульсов рефлектометра от 25 до 300 нс. Установлено, что волоконно-оптический датчик может работать на любой длине волны оптического излучения, соответствующей окнам прозрачности спектра оптических потерь волокна. Исследовано влияние длины оптического волокна между регистрирующим устройством и местом определения концентрации раствора жидкости с помощью волоконно-оптического датчика

ВЛИЯНИЕ ЭЛЕКТРОННОГО ОБЛУЧЕНИЯ НА ЭЛЕКТРИЧЕСКИЕ ХАРАКТЕРИСТИКИ p-n-СТРУКТУР НА ЯДЕРНО-ЛЕГИРОВАННОМ КРЕМНИИ

The article studies the effect of electron radiation with energy of 4 MeV on the characteristics of high-voltage (4.5 kV) silicon diode p-n-structures based on nuclear-doped silicon. During the research the dose dependences of the correlations between the static and dynamic characteristics of the p-n structures were built, and the radiation damage coefficient of minority carrier lifetime Kτ was determined. Using the DLTS-spectroscopy method, the formation in the band-gap of basic n-Si of six energy levels of radiation defects affecting the characteristics of irradiated p-n-structures was determined. В работе проведены исследования влияния электронного облучения с энергией 4 МэВ на характеристики высоковольтных (до 4,5 кВ) диодных кремниевых p-n-структур, изготовленных на ядерно-легированном кремнии. Получены дозовые зависимости статических и динамических характеристик p-n-структур, определен коэффициент радиационных повреждений времени жизни неосновных носителей заряда Kτ . С помощью метода DLTS-спектроскопии определено образование в запрещенной зоне базового n-Si шести энергетических уровней радиационных дефектов, влияющих на характеристики облученных p-n-структур.

Clinico-anamnestic and immunological characteristics of premature infants with respiratory distress syndrome

Purpose of the study: compare perinatal factors, clinical-anamnestic data and the levels of anti-inflammatory IL-10 and indirect marker of fibrosis - metalloproteinase 3 (MMP3) in preterm infants with and without respiratory distress syndrome (RDS) to clarify their role in the pathogenesis of lung injury during the period from 3 to 6 weeks of life.Patients and methods: 15 premature infants with RDS (group 1) and 10 premature infants without RDS (group 2) were examined in the same period of life.Results: The proportion of children with reduced IL-10 was 60% in group 1 compared to 20% in group 2 (p = 0.048). The proportions of children with reduced MMP3 were 47 and 27%, respectively (p = 0.17). The proportions of elevated IL-10 and MMP3 values were comparable in the two groups (27 and 20% for IL-10 and 13 and 10% for MMP3), the data was unreliable. Children with elevated IL-10 in combination with decreased MMP3 had a history of frequent ARVI complicated by obstructive bronchitis and pneumonia in the first year of life.Conclusion: Premature infants with RDS are characterized by reduced levels of IL-10 and MMP3 compared with the same biomarkers for premature infants without RDS