Hippocampal glucocorticoid receptor and microRNA gene expression and serum cortisol concentration in foxes selected for behavior toward humans

In many cases, stress reactivity is one of the important bases of aggressive behavior. It appears as if reduced stress reactivity underlies an abrupt decrease in aggression towards man in domesticated animals. However, the mechanisms of this reduction have yet to be resolved. In this work, we used an experimental domestication model, the silver fox selected for many years for the response to humans to study cortisol stress reactivity in tame and aggressive foxes in response to immobilization in human arms. Additionally, these behavioral fox groups were explored for one of the important mechanisms of glucocorticoid negative feedback, the expression of the glucocorticoid receptor gene (NR3C1) in a portion of the dorsal hippocampus. In recent years, attention has been paid to differences in miRNA expression patterns between animals with different behavior and stress reactivity, as well as to miRNA regulation under stress. The same applies to NR3C1 mRNA as well. That is why we performed a miRNA-seq analysis on a portion of the fox dorsal hippocampus. It has been demonstrated that immobilization in human arms leads to significantly higher stressinduced cortisol levels in aggressive than tame foxes. At the same time, no differences have been found between hippocampal NR3C1 gene expression and the pattern of miRNA expression. Thus, reduced stress reactivity in foxes during selection for the absence of aggressive responses and for the presence of emotionally positive responses to humans does not seem to be associated with important mechanisms of regulation such as alterations in hippocampal NR3C1 gene expression or microRNA-mediated silencing

Качество жизни больных циррозом печени в зависимости от тонуса вегетативной нервной системы

At present, medical attention is paid to the quality of life for patients. The dependence between the quality of life and the course of the disease, personality patients characteristics. In the conducted study involved 139 patients with cirrhosis of the liver. With the help of questionnaires, self-administered by patients, assessed the quality of life depending on the tone of the autonomic nervous system. As a result of supervision it is established that the vegetative disbalance at sick of a cirrhosis with prevalence of parasympathetic influences worsens indicators of quality of life in spheres of vigor, painful sensations and emotional reactions.В настоящее время в медицине большое внимание уделяется изучению качества жизни (КЖ) пациентов. Исследуется зависимость между КЖ и течением заболевания, особенностями личности пациента. В представленном исследовании принимали участие 139 больных циррозом печени (ЦП). При помощи анкет, самостоятельно заполняемых пациентами, оценивалось КЖ в зависимости от тонуса вегетативной нервной системы. В результате наблюдения установлено, что вегетативный дисбаланс у больных циррозом печени с преобладанием парасимпатических влияний ухудшает показатели КЖ в сферах энергичности, болевых ощущений и эмоциональных реакций

Optimization of adaptive traffic light control modes based on machine vision

Urbanization leads to a significant increase in traffic density in large cities. The growing transport concentration is accompanied by an increase in traffic congestion and emissions of harmful substances. The policies and decisions developed by the authorities, such as the expansion of existing roads and construction of new roads, as well as increase in transport taxes, no longer make it possible to maintain the adequate mobility of the population. One of the solutions is to increase the efficiency of road infrastructure utilization by forecasting the traffic situation and using the adaptive adjustment of traffic lights operation. With dynamic collection and interpretation of traffic flow data from traffic monitoring cameras, it will be possible to use the dynamic parameters of vehicles as indicators for the adaptive adjustment of traffic light regulation. The first part of the paper describes the use of machine vision and a neural network (YOLOv4) in tracking the parameters of traffic flows on road sections in front of intersections. The second part of the paper presents a methodology based on the dynamic regulation of traffic lights cycles and their duration, taking into account the current and forecast parameters of the traffic flow. The algorithm for the adaptive adjustment of traffic lights regulation considers the following parameters: the number and dynamic dimensions of vehicles moving towards the intersection; the number of vehicles in the queue in front of the stop line and their acceleration at the start of the movement. We determined the relationship of the intersection capacity when driving straight ahead with the dynamic dimensions of vehicles and the formation of a queue in front of the stop line, waiting for the green light. The study resulted in the development of an algorithm for setting the duration of both a particular phase and the entire traffic lights cycle in the tasks of eliminating or minimizing the possibility of congestion

Psychovegetative features at sick of the cirrhosis

Complex kliniko-tool, laboratory, psychovegetative investigation of 139 various aetiologies sick by a cirrhosis (virus, alcoholic, mixed) is carried and severity levels on Childs-Pugh. The comparison group has been presented by 104 sick chronic hepatitises virus, alcoholic and mixed aetiologies. The control group included 30 healthy the person comparable floor and age. At sick of a cirrhosis, also as at sick of a chronic hepatitis, emotionally-labile, neurotic lines and high personal uneasiness prevailed. The tendency to sympathicotonia depended on weight of defeat of a liver. Prevalence of a tone and reactance of sympathetic department of vegetative nervous system is a compensatory strengthening of adaptive mechanisms

Quality of life in patients with liver cirrhosis on the tone of vegetative nervous system

At present, medical attention is paid to the quality of life for patients. The dependence between the quality of life and the course of the disease, personality patients characteristics. In the conducted study involved 139 patients with cirrhosis of the liver. With the help of questionnaires, self-administered by patients, assessed the quality of life depending on the tone of the autonomic nervous system. As a result of supervision it is established that the vegetative disbalance at sick of a cirrhosis with prevalence of parasympathetic influences worsens indicators of quality of life in spheres of vigor, painful sensations and emotional reactions