Self-assembly of p-tert-butyl thiacalix[4]arenes and metal cations into nanoscale three-dimensional particles

The shape of supramolecular aggregates based on stereoisomers of p-tert-butyl thiacalix[4]arenes functionalized with secondary, tertiary amide and hydrazide groups at the lower rim in cone, partial cone and 1,3-alternate conformations with several metal cations were investigated by atomic force microscopy. The examined p-tert-butyl thiacalix[4]arenes form host-guest complexes; dimers, spherics ellipsoids and elongated nanoscale particles depending on the conformation of macrocycles, the nature of the binding centers and the nature of the metal cation. Only associates formed by p-tert-butyl thiacalix[4]arenes with morpholide groups at the lower rim in cone conformation with silver cations exhibited a higher antimicrobial activity. Copyright © 2012 John Wiley & Sons, Ltd

HOSPITAL-ACQUIRED PNEUMONIA ASSOCIATED WITH THE CAUSATIVE AGENT STENOTROPHOMONAS MALTOPHILIA, IN NEWBORN INFANTS

Objective: to analyze the clinical course of ventilator-associated pneumonia caused by Stenotrophomonas maltophilia in infants as a high-risk group for the development of hospital acquired infection, as well as a study of the sensitivity of the pathogen to antibiotics.Eighteen infants (14 premature and 4 mature infants) with ventilator -associated pneumonia due to (Stenotrophomonas maltophilia) were monitored. The disease occurred in the majority (72%) of infants as a monoinfection, more often in severe and acute form with severe toxicosis, trophic disorders, severe respiratory failure, bilateral lung and bronchial lesions. In 33% of children, mostly premature, there was a change in the pathogen, which increased the severity and duration of the disease. Pneumonia had complications in the form of sepsis (6%) and bronchopulmonary dysplasia (28%). Most Stenotrophomonas maltophilia retained sensitivity to ticarcillin + clavulanate, ciprofloxacin, chloramphenicol and co-trimoxazol

Self-assembly of p-tert-butyl thiacalix[4]arenes and metal cations into nanoscale three-dimensional particles

The shape of supramolecular aggregates based on stereoisomers of p-tert-butyl thiacalix[4]arenes functionalized with secondary, tertiary amide and hydrazide groups at the lower rim in cone, partial cone and 1,3-alternate conformations with several metal cations were investigated by atomic force microscopy. The examined p-tert-butyl thiacalix[4]arenes form host-guest complexes; dimers, spherics ellipsoids and elongated nanoscale particles depending on the conformation of macrocycles, the nature of the binding centers and the nature of the metal cation. Only associates formed by p-tert-butyl thiacalix[4]arenes with morpholide groups at the lower rim in cone conformation with silver cations exhibited a higher antimicrobial activity. Copyright © 2012 John Wiley & Sons, Ltd

Self-assembly of p-tert-butyl thiacalix[4]arenes and metal cations into nanoscale three-dimensional particles

The shape of supramolecular aggregates based on stereoisomers of p-tert-butyl thiacalix[4]arenes functionalized with secondary, tertiary amide and hydrazide groups at the lower rim in cone, partial cone and 1,3-alternate conformations with several metal cations were investigated by atomic force microscopy. The examined p-tert-butyl thiacalix[4]arenes form host-guest complexes; dimers, spherics ellipsoids and elongated nanoscale particles depending on the conformation of macrocycles, the nature of the binding centers and the nature of the metal cation. Only associates formed by p-tert-butyl thiacalix[4]arenes with morpholide groups at the lower rim in cone conformation with silver cations exhibited a higher antimicrobial activity. Copyright © 2012 John Wiley & Sons, Ltd

Self-assembly of p-tert-butyl thiacalix[4]arenes and metal cations into nanoscale three-dimensional particles

The shape of supramolecular aggregates based on stereoisomers of p-tert-butyl thiacalix[4]arenes functionalized with secondary, tertiary amide and hydrazide groups at the lower rim in cone, partial cone and 1,3-alternate conformations with several metal cations were investigated by atomic force microscopy. The examined p-tert-butyl thiacalix[4]arenes form host-guest complexes; dimers, spherics ellipsoids and elongated nanoscale particles depending on the conformation of macrocycles, the nature of the binding centers and the nature of the metal cation. Only associates formed by p-tert-butyl thiacalix[4]arenes with morpholide groups at the lower rim in cone conformation with silver cations exhibited a higher antimicrobial activity. Copyright © 2012 John Wiley & Sons, Ltd