16 research outputs found
Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries
Extremity and soft tissue injuries contribute significantly to inflammation and adverse in-hospital outcomes for trauma survivors; accordingly, we examined the complex association between clinical outcomes inflammatory responses in this setting using in silico tools. Two stringently propensity-matched, moderately/severely injured (Injury Severity Score > 16) patient sub-cohorts of ~30 patients each were derived retrospectively from a cohort of 472 blunt trauma survivors and segregated based on their degree of extremity injury severity (above or below 3 on the Abbreviated Injury Scale). Serial blood samples were analyzed for 31 plasma inflammatory mediators. In addition to standard statistical analyses, Dynamic Network Analysis (DyNA) and Principal Component Analysis (PCA) were used to model systemic inflammation following trauma. Patients in the severe extremity injury sub-cohort experienced longer intensive care unit length of stay (LOS), total LOS, and days on a mechanical ventilator, with higher Marshall Multiple Organ Dysfunction (MOD) Scores over the first 7 days post-injury as compared to the mild/moderate extremity injury sub-cohort. The higher severity cohort had statistically significant elevated lactate, base deficit, and creatine phosphokinase on first blood draw, along with significant changes in multiple circulating inflammatory mediators. DyNA pointed to a sustained role for type 17 immunity in both sub-cohorts, along with IFN-Îł in the severe extremity injury group. DyNA network complexity increased over 7 days post-injury in the severe injury group, while generally decreasing over this same time period in the mild/moderate injury group. PCA suggested a more robust activation of multiple pathways in the severe extremity injury group as compared to the mild/moderate injury group. These studies thus point to the possibility of self-sustaining inflammation following severe extremity injury vs. resolving inflammation following less severe extremity injury
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Waste heat recovery solution based on a heat pipe heat exchanger for the aluminium die casting industry
Data availability: Data will be made available on request.Copyright © 2022 The Authors. An analysis of the end use of energy in the EU reveals that industry is one of the three dominant categories, which accounts for 26.1% of the final end use of energy. In the case of the aluminium industry, approximately 70% of energy consumption is due to heat and thermal processes, highlighting a vast potential for waste heat recovery technologies. Within the aluminium die casting industry, liquid aluminium is cast, formed, cooled, and further processed within a thermal heat process, which includes three sub-processes: solubilising, quenching, and ageing. In the case presented, a thermal heat process is the second most energy intensive process within the factory, and the ageing heat treatment furnace accounts for 15% of the thermal heat process. The thermal heat treatment generates a significant amount of waste heat. The recovery of that waste heat, with minimal risk of cross contamination between streams and reduced chance of equipment failure, has been achieved via the use of a heat pipe heat exchanger (HPHE). The HPHE has been designed, manufactured, and installed in the solution furnace exhaust stack. The HPHE was designed to recover up to 88.6 kW in steady state operating conditions at 400 °C. The return on investment has been evaluated at 35 months with an expected CO2 emissions reduction of 86 tCO2/year when best engineering practices are applied. Furthermore, a theoretical modelling tool to predict the thermal performance of the HPHE was developed and validated within a ±20% deviation from the experimental results. This paper further presents the development of the theoretical model to allow a characterisation of HPHE technology and will act as a guideline for the design of HPHEs within the aluminium industry.European Commission and the partners of the European H2020 project “Heat pipe technology for thermal energy recovery in industrial applications” (https://www.etekina.eu/, H2020-EE-2017-PPP- 768772). Additional information is available in the project Web page www.etekina.eu or www.etekina.com